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lasI acyl-homoserine-lactone synthase [ Pseudomonas aeruginosa PAO1 ]

Gene ID: 881777, updated on 11-Sep-2024
Gene symbol
lasI
Gene description
acyl-homoserine-lactone synthase
Locus tag
PA1432
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Pseudomonas aeruginosa PAO1 (strain: PAO1)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas
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Sequence:
NC_002516.2 (1559254..1559859)

NC_002516.2Genomic Context describing neighboring genes Neighboring gene cation-transporting P-type ATPase Neighboring gene transcriptional regulator LasR Neighboring gene regulatory protein RsaL Neighboring gene hypothetical protein Neighboring gene hypothetical protein

Genomic Sequence:
NC_002516.2

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Expression of Pseudomonas aeruginosa virulence genes requires cell-to-cell communication. Passador L, et al. Science, 1993 May 21. PMID 8493556
  2. Pseudomonas aeruginosa las and rhl quorum-sensing systems are important for infection and inflammation in a rat prostatitis model. Nelson LK, et al. Microbiology (Reading), 2009 Aug. PMID 19460822
  3. Examination of Pseudomonas aeruginosa lasI regulation and 3-oxo-C12-homoserine lactone production using a heterologous Escherichia coli system. Wargo MJ, et al. FEMS Microbiol Lett, 2007 Aug. PMID 17559399
  4. Relative expression of Pseudomonas aeruginosa virulence genes analyzed by a real time RT-PCR method during lung infection in rats. Joly B, et al. FEMS Microbiol Lett, 2005 Feb 1. PMID 15668029
  5. Sub-inhibitory concentrations of antibiotics and wastewater influencing biofilm formation and gene expression of multi-resistant Pseudomonas aeruginosa wastewater isolates. Bruchmann J, et al. Environ Sci Pollut Res Int, 2013 Jun. PMID 23392972

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Subinhibitory concentrations of macrolides specifically upregulated expression of quorum sensing genes (rhlR, lasI), whereas sulfonamides and municipal wastewater, instead upregulated expression of specific resistant genes (sul1) and efflux pumps (mexD).
    Title: Sub-inhibitory concentrations of antibiotics and wastewater influencing biofilm formation and gene expression of multi-resistant Pseudomonas aeruginosa wastewater isolates.
  2. The quorum-sensing lasI and rhlI genes in Ps. aeruginosa affect acute prostate infections, but play a considerably more important role in maintaining chronic infections.
    Title: Pseudomonas aeruginosa las and rhl quorum-sensing systems are important for infection and inflammation in a rat prostatitis model.
  3. Data found that Lon represses the expression of LasR/LasI by degrading LasI, an HSL synthase, leading to negative regulation of the RhlR/RhlI system.
    Title: Negative regulation of quorum-sensing systems in Pseudomonas aeruginosa by ATP-dependent Lon protease.
  4. artificially increasing lasI transcript levels leads to higher levels of 3OC12HSL.
    Title: Examination of Pseudomonas aeruginosa lasI regulation and 3-oxo-C12-homoserine lactone production using a heterologous Escherichia coli system.
  5. Transcription remained more constant throughout the lung infection.
    Title: Relative expression of Pseudomonas aeruginosa virulence genes analyzed by a real time RT-PCR method during lung infection in rats.
Submit: New GeneRIF Correction

Homology

Gene Ontology Provided by PseudoCAP

Process Evidence Code Pubs
acts_upstream_of_or_within signal transduction IDA
Inferred from Direct Assay
more info
 PubMed 
Preferred Names
acyl-homoserine-lactone synthase
NP_250123.1
  • Product name confidence: class 1 (Function experimentally demonstrated in P. aeruginosa)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_002516.2 Reference assembly

    Range
    1559254..1559859
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_250123.1 acyl-homoserine-lactone synthase [Pseudomonas aeruginosa PAO1]

    See identical proteins and their annotated locations for NP_250123.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A411F6U8, A0A7G9KWD1
    Conserved Domains (1) summary
    COG3916
    Location:1 → 197
    LasI; N-acyl-L-homoserine lactone synthetase [Signal transduction mechanisms]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P33883.1

Gene LinkOut

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Molecular Biology Databases
Research Materials