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gbuA guanidinobutyrase [ Pseudomonas aeruginosa PAO1 ]

Gene ID: 881747, updated on 30-Jul-2025
Gene symbol
gbuA
Gene description
guanidinobutyrase
Locus tag
PA1421
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Pseudomonas aeruginosa PAO1 (strain: PAO1)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas
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Sequence:
NC_002516.2 (1546271..1547230, complement)

NC_002516.2Genomic Context describing neighboring genes Neighboring gene transporter Neighboring gene hypothetical protein Neighboring gene protein GbuR Neighboring gene biofilm dispersion protein

Genomic Sequence:
NC_002516.2

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. The guanidinobutyrase GbuA is essential for the alkylquinolone-regulated pyocyanin production during parasitic growth of Pseudomonas aeruginosa in co-culture with Aeromonas hydrophila. Jagmann N, et al. Environ Microbiol, 2016 Oct. PMID 27322205
  2. The fourth arginine catabolic pathway of Pseudomonas aeruginosa. Jann A, et al. J Gen Microbiol, 1988 Apr. PMID 3141581
  3. Pseudomonas Genome Database: facilitating user-friendly, comprehensive comparisons of microbial genomes. Winsor GL, et al. Nucleic Acids Res, 2009 Jan. PMID 18978025, Free PMC Article
  4. Defining the Pseudomonas aeruginosa SOS response and its role in the global response to the antibiotic ciprofloxacin. Cirz RT, et al. J Bacteriol, 2006 Oct. PMID 17015649, Free PMC Article
  5. Cystic fibrosis sputum supports growth and cues key aspects of Pseudomonas aeruginosa physiology. Palmer KL, et al. J Bacteriol, 2005 Aug. PMID 16030221, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Deletion of GbuA leds to a loss of pyocyanin production in co-cultures and to a reduced pyocyanin production in single cultures.
    Title: The guanidinobutyrase GbuA is essential for the alkylquinolone-regulated pyocyanin production during parasitic growth of Pseudomonas aeruginosa in co-culture with Aeromonas hydrophila.
Submit: New GeneRIF Correction

Homology

Gene Ontology Provided by PseudoCAP

Function Evidence Code Pubs
enables guanidinobutyrase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables guanidinobutyrase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in L-arginine catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
Preferred Names
guanidinobutyrase
NP_250112.1
  • Product name confidence: class 1 (Function experimentally demonstrated in P. aeruginosa)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_002516.2 Reference assembly

    Range
    1546271..1547230 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_250112.1 guanidinobutyrase [Pseudomonas aeruginosa PAO1]

    See identical proteins and their annotated locations for NP_250112.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A367M4N2
    Conserved Domains (1) summary
    cd11592
    Location:19 → 310
    Agmatinase_PAH; Agmatinase-like family includes proclavaminic acid amidinohydrolase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9I3S3.1

Gene LinkOut

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Molecular Biology Databases
Research Materials