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FGF18 fibroblast growth factor 18 [ Homo sapiens (human) ]

Gene ID: 8817, updated on 7-Jun-2020

Summary

Official Symbol
FGF18provided by HGNC
Official Full Name
fibroblast growth factor 18provided by HGNC
Primary source
HGNC:HGNC:3674
See related
Ensembl:ENSG00000156427 MIM:603726
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZFGF5; FGF-18
Summary
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. It has been shown in vitro that this protein is able to induce neurite outgrowth in PC12 cells. Studies of the similar proteins in mouse and chick suggested that this protein is a pleiotropic growth factor that stimulates proliferation in a number of tissues, most notably the liver and small intestine. Knockout studies of the similar gene in mice implied the role of this protein in regulating proliferation and differentiation of midline cerebellar structures. [provided by RefSeq, Jul 2008]
Expression
Biased expression in heart (RPKM 3.7), lung (RPKM 0.9) and 12 other tissues See more
Orthologs

Genomic context

See FGF18 in Genome Data Viewer
Location:
5q35.1
Exon count:
5
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (171419647..171457626)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (170846667..170884630)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene microRNA 3912 Neighboring gene nucleophosmin 1 Neighboring gene uncharacterized LOC105377721 Neighboring gene uncharacterized LOC105377720 Neighboring gene uncharacterized LOC105377722 Neighboring gene uncharacterized LOC107986392

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
growth factor activity IEA
Inferred from Electronic Annotation
more info
 
type 1 fibroblast growth factor receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
type 2 fibroblast growth factor receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
MAPK cascade TAS
Traceable Author Statement
more info
 
anatomical structure morphogenesis TAS
Traceable Author Statement
more info
PubMed 
angiogenesis IEA
Inferred from Electronic Annotation
more info
 
cell-cell signaling TAS
Traceable Author Statement
more info
PubMed 
chondrocyte development IEA
Inferred from Electronic Annotation
more info
 
endochondral ossification IEA
Inferred from Electronic Annotation
more info
 
fibroblast growth factor receptor signaling pathway TAS
Traceable Author Statement
more info
 
intramembranous ossification IEA
Inferred from Electronic Annotation
more info
 
lung development IEA
Inferred from Electronic Annotation
more info
 
positive regulation of ERK1 and ERK2 cascade IEA
Inferred from Electronic Annotation
more info
 
positive regulation of MAP kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of angiogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of blood vessel endothelial cell migration IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of cell proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of chondrocyte differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of endothelial cell chemotaxis to fibroblast growth factor IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein kinase B signaling TAS
Traceable Author Statement
more info
 
positive regulation of vascular endothelial growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
NOT regulation of endothelial cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
NOT regulation of sprouting angiogenesis IDA
Inferred from Direct Assay
more info
PubMed 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space TAS
Traceable Author Statement
more info
PubMed 
nucleolus IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
fibroblast growth factor 18

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029158.1 RefSeqGene

    Range
    4985..42964
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_003862.3NP_003853.1  fibroblast growth factor 18 precursor

    See identical proteins and their annotated locations for NP_003853.1

    Status: REVIEWED

    Source sequence(s)
    AC093246, AF075292, BQ018759
    Consensus CDS
    CCDS4378.1
    UniProtKB/Swiss-Prot
    O76093
    Related
    ENSP00000274625.5, ENST00000274625.6
    Conserved Domains (1) summary
    pfam00167
    Location:53175
    FGF; Fibroblast growth factor

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    171419647..171457626
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_033649.1: Suppressed sequence

    Description
    NM_033649.1: This RefSeq was permanently suppressed because it is a nonsense-mediated decay (NMD) candidate.
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