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tpbB diguanylate cyclase [ Pseudomonas aeruginosa PAO1 ]

Gene ID: 881684, updated on 19-Nov-2025
Gene symbol
tpbB
Gene description
diguanylate cyclase
Locus tag
PA1120
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Pseudomonas aeruginosa PAO1 (strain: PAO1)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas
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Sequence:
NC_002516.2 (1213195..1214502, complement)

NC_002516.2Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene hypothetical protein Neighboring gene hypothetical protein Neighboring gene hypothetical protein Neighboring gene pseudo Neighboring gene hypothetical protein

Genomic Sequence:
NC_002516.2

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Structural basis for diguanylate cyclase activation by its binding partner in Pseudomonas aeruginosa. Chen G, et al. Elife, 2021 Sep 9. PMID 34498587, Free PMC Article
  2. Bacterial cyclic diguanylate signaling networks sense temperature. Almblad H, et al. Nat Commun, 2021 Mar 31. PMID 33790266, Free PMC Article
  3. Matrix Polysaccharides and SiaD Diguanylate Cyclase Alter Community Structure and Competitiveness of Pseudomonas aeruginosa during Dual-Species Biofilm Development with Staphylococcus aureus. Chew SC, et al. mBio, 2018 Nov 6. PMID 30401769, Free PMC Article
  4. Connecting quorum sensing, c-di-GMP, pel polysaccharide, and biofilm formation in Pseudomonas aeruginosa through tyrosine phosphatase TpbA (PA3885). Ueda A, et al. PLoS Pathog, 2009 Jun. PMID 19543378, Free PMC Article
  5. Analysis of Pseudomonas aeruginosa diguanylate cyclases and phosphodiesterases reveals a role for bis-(3'-5')-cyclic-GMP in virulence. Kulasakara H, et al. Proc Natl Acad Sci U S A, 2006 Feb 21. PMID 16477007, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Structural basis for diguanylate cyclase activation by its binding partner in Pseudomonas aeruginosa.
    Title: Structural basis for diguanylate cyclase activation by its binding partner in Pseudomonas aeruginosa.
  2. Bacterial cyclic diguanylate signaling networks sense temperature.
    Title: Bacterial cyclic diguanylate signaling networks sense temperature.
  3. Our data suggest that the competitive effect of Psl polysaccharides is not associated with its structural role in cross-linking the matrix and adhering to P. aeruginosa cells but is instead mediated through the activation of the diguanylate cyclase SiaD.
    Title: Matrix Polysaccharides and SiaD Diguanylate Cyclase Alter Community Structure and Competitiveness of Pseudomonas aeruginosa during Dual-Species Biofilm Development with Staphylococcus aureus.
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Homology

Gene Ontology Provided by PseudoCAP

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables diguanylate cyclase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables diguanylate cyclase activity IEA
Inferred from Electronic Annotation
more info
  
enables diguanylate cyclase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
diguanylate cyclase
NP_249811.1
  • Product name confidence: class 1: Function experimentally demonstrated in P. aeruginosa

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_002516.2 Reference assembly

    Range
    1213195..1214502 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_249811.1 diguanylate cyclase [Pseudomonas aeruginosa PAO1]

    See identical proteins and their annotated locations for NP_249811.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A367MCN9
    Conserved Domains (1) summary
    PRK09966
    Location:10 → 410
    PRK09966; diguanylate cyclase DgcN
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9I4L5.1

Gene LinkOut

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Molecular Biology Databases