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cbrB two-component response regulator CbrB [ Pseudomonas aeruginosa PAO1 ]

Gene ID: 881609, updated on 11-Sep-2024
Gene symbol
cbrB
Gene description
two-component response regulator CbrB
Locus tag
PA4726
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Pseudomonas aeruginosa PAO1 (strain: PAO1)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas
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Sequence:
NC_002516.2 (5306989..5308425)

NC_002516.2Genomic Context describing neighboring genes Neighboring gene glutamyl-Q tRNA(Asp) synthetase Neighboring gene hypothetical protein Neighboring gene two-component sensor CbrA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

Genomic Sequence:
NC_002516.2

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Promoter recognition and activation by the global response regulator CbrB in Pseudomonas aeruginosa. Abdou L, et al. J Bacteriol, 2011 Jun. PMID 21478360, Free PMC Article
  2. Inactivation of CbrAB two-component system hampers root colonization in rhizospheric strain of Pseudomonas aeruginosa PGPR2. Sivakumar R, et al. Biochim Biophys Acta Gene Regul Mech, 2021 Nov-Dec. PMID 34530138
  3. The sensor kinase CbrA is a global regulator that modulates metabolism, virulence, and antibiotic resistance in Pseudomonas aeruginosa. Yeung AT, et al. J Bacteriol, 2011 Feb. PMID 21169488, Free PMC Article
  4. The CbrA-CbrB two-component regulatory system controls the utilization of multiple carbon and nitrogen sources in Pseudomonas aeruginosa. Nishijyo T, et al. Mol Microbiol, 2001 May. PMID 11401699
  5. Regulation of carbon and nitrogen utilization by CbrAB and NtrBC two-component systems in Pseudomonas aeruginosa. Li W, et al. J Bacteriol, 2007 Aug. PMID 17545289, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Inactivation of CbrAB two-component system hampers root colonization in rhizospheric strain of Pseudomonas aeruginosa PGPR2.
    Title: Inactivation of CbrAB two-component system hampers root colonization in rhizospheric strain of Pseudomonas aeruginosa PGPR2.
  2. Here we have identified a conserved palindromic nucleotide sequence that is present in upstream activating sequences (UASs) of promoters under positive control by CbrB and sigma(54) RNA polymerase, especially in the UAS of the crcZ promoter.
    Title: Promoter recognition and activation by the global response regulator CbrB in Pseudomonas aeruginosa.
  3. In summary, this study supports the notion that CbrAB and NtrBC form a network to control the C/N balance in P. aeruginosa.
    Title: Regulation of carbon and nitrogen utilization by CbrAB and NtrBC two-component systems in Pseudomonas aeruginosa.
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Homology

Gene Ontology Provided by PseudoCAP

Function Evidence Code Pubs
enables phosphorelay response regulator activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within positive regulation of cell motility IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of proline catabolic process to glutamate IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of arginine catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of ornithine metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Preferred Names
two-component response regulator CbrB
NP_253414.1
  • Product name confidence: class 1 (Function experimentally demonstrated in P. aeruginosa)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_002516.2 Reference assembly

    Range
    5306989..5308425
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_253414.1 two-component response regulator CbrB [Pseudomonas aeruginosa PAO1]

    See identical proteins and their annotated locations for NP_253414.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A3M5EU12
    Conserved Domains (1) summary
    COG2204
    Location:1 → 469
    AtoC; DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, and a Fis-type DNA-binding domains [Signal transduction mechanisms]
Nucleotide Protein
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