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DCAF5 DDB1 and CUL4 associated factor 5 [ Homo sapiens (human) ]

Gene ID: 8816, updated on 5-Jul-2020

Summary

Official Symbol
DCAF5provided by HGNC
Official Full Name
DDB1 and CUL4 associated factor 5provided by HGNC
Primary source
HGNC:HGNC:20224
See related
Ensembl:ENSG00000139990 MIM:603812
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BCRG2; BCRP2; WDR22; D14S1461E
Expression
Ubiquitous expression in testis (RPKM 20.5), thyroid (RPKM 9.2) and 25 other tissues See more
Orthologs

Genomic context

See DCAF5 in Genome Data Viewer
Location:
14q24.1
Exon count:
14
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (69050881..69153393, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (69517637..69619914, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene ACTN1 antisense RNA 1 Neighboring gene ribosomal protein S29 pseudogene 1 Neighboring gene DEAD-box helicase 18 pseudogene 1 Neighboring gene uncharacterized LOC105370550 Neighboring gene exonuclease 3'-5' domain containing 2 Neighboring gene polypeptide N-acetylgalactosaminyltransferase 16 Neighboring gene uncharacterized LOC105370549

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA1824, DKFZp434A035

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
post-translational protein modification TAS
Traceable Author Statement
more info
 
protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Cul4-RING E3 ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Cul4-RING E3 ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
DDB1- and CUL4-associated factor 5
Names
WD repeat-containing protein 22
breakpoint cluster region protein, uterine leiomyoma, 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001284206.1NP_001271135.1  DDB1- and CUL4-associated factor 5 isoform 2

    See identical proteins and their annotated locations for NP_001271135.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AK094283, BC013239, BC136632, BM681039, BX648006
    Consensus CDS
    CCDS61481.1
    UniProtKB/Swiss-Prot
    Q96JK2
    Related
    ENSP00000451845.1, ENST00000557386.5
    Conserved Domains (3) summary
    COG2319
    Location:16360
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:105139
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:49360
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  2. NM_001284207.1NP_001271136.1  DDB1- and CUL4-associated factor 5 isoform 3

    See identical proteins and their annotated locations for NP_001271136.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus than isoform 1.
    Source sequence(s)
    AB058727, AL831932, BC013239, BC136632, BM681039, BX648006
    Consensus CDS
    CCDS61480.1
    UniProtKB/Swiss-Prot
    Q96JK2
    Related
    ENSP00000451551.1, ENST00000554215.5
    Conserved Domains (3) summary
    COG2319
    Location:7279
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:2258
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:13317
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  3. NM_001284208.2NP_001271137.1  DDB1- and CUL4-associated factor 5 isoform 4

    See identical proteins and their annotated locations for NP_001271137.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks multiple 3' exons and contains an alternate 3' exon, resulting in a distinct 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (4) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK094283, BC022967, DB507867
    Consensus CDS
    CCDS73646.1
    UniProtKB/TrEMBL
    Q8TBB7
    Related
    ENSP00000374647.6, ENST00000389997.10
    Conserved Domains (2) summary
    sd00039
    Location:5798
    7WD40; WD40 repeat [structural motif]
    cl25539
    Location:49248
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  4. NM_003861.3NP_003852.1  DDB1- and CUL4-associated factor 5 isoform 1

    See identical proteins and their annotated locations for NP_003852.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AB058727, AL391262, BC013239, BC136632, BX648006, DA058347, R41943
    Consensus CDS
    CCDS32106.1
    UniProtKB/Swiss-Prot
    Q96JK2
    Related
    ENSP00000341351.5, ENST00000341516.10
    Conserved Domains (3) summary
    COG2319
    Location:16361
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:5798
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:49361
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    69050881..69153393 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011537278.1XP_011535580.1  DDB1- and CUL4-associated factor 5 isoform X3

    See identical proteins and their annotated locations for XP_011535580.1

    Conserved Domains (3) summary
    COG2319
    Location:18319
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:2258
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:13356
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  2. XM_006720298.2XP_006720361.1  DDB1- and CUL4-associated factor 5 isoform X2

    Conserved Domains (3) summary
    COG2319
    Location:16395
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:5798
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:49395
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  3. XM_006720297.2XP_006720360.1  DDB1- and CUL4-associated factor 5 isoform X1

    Conserved Domains (3) summary
    COG2319
    Location:16396
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:5798
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:49396
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  4. XM_017021736.1XP_016877225.1  DDB1- and CUL4-associated factor 5 isoform X6

  5. XM_006720300.2XP_006720363.1  DDB1- and CUL4-associated factor 5 isoform X4

    Conserved Domains (3) summary
    COG2319
    Location:18318
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:2256
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:13355
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  6. XM_017021734.1XP_016877223.1  DDB1- and CUL4-associated factor 5 isoform X5

    UniProtKB/Swiss-Prot
    Q96JK2
    Conserved Domains (3) summary
    COG2319
    Location:7279
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:2258
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:13317
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  7. XM_017021739.1XP_016877228.1  DDB1- and CUL4-associated factor 5 isoform X9

  8. XM_017021738.1XP_016877227.1  DDB1- and CUL4-associated factor 5 isoform X9

  9. XM_017021735.1XP_016877224.1  DDB1- and CUL4-associated factor 5 isoform X5

    UniProtKB/Swiss-Prot
    Q96JK2
    Related
    ENSP00000452052.1, ENST00000556847.5
    Conserved Domains (3) summary
    COG2319
    Location:7279
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:2258
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:13317
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  10. XM_011537279.2XP_011535581.1  DDB1- and CUL4-associated factor 5 isoform X3

    See identical proteins and their annotated locations for XP_011535581.1

    Conserved Domains (3) summary
    COG2319
    Location:18319
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:2258
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:13356
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  11. XM_017021733.1XP_016877222.1  DDB1- and CUL4-associated factor 5 isoform X3

    Conserved Domains (3) summary
    COG2319
    Location:18319
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:2258
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:13356
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  12. XM_017021737.1XP_016877226.1  DDB1- and CUL4-associated factor 5 isoform X8

  13. XM_011537280.3XP_011535582.1  DDB1- and CUL4-associated factor 5 isoform X7

    Conserved Domains (1) summary
    cl02567
    Location:107217
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  14. XM_006720299.3XP_006720362.1  DDB1- and CUL4-associated factor 5 isoform X3

    See identical proteins and their annotated locations for XP_006720362.1

    Conserved Domains (3) summary
    COG2319
    Location:18319
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:2258
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:13356
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
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