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dksA suppressor protein DksA [ Pseudomonas aeruginosa PAO1 ]

Gene ID: 881594, updated on 30-Jul-2025
Gene symbol
dksA
Gene description
suppressor protein DksA
Locus tag
PA4723
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Pseudomonas aeruginosa PAO1 (strain: PAO1)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas
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Sequence:
NC_002516.2 (5302386..5302832)

NC_002516.2Genomic Context describing neighboring genes Neighboring gene sugar fermentation stimulation protein A Neighboring gene hypothetical protein Neighboring gene glutamyl-Q tRNA(Asp) synthetase Neighboring gene hypothetical protein Neighboring gene two-component sensor CbrA

Genomic Sequence:
NC_002516.2

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. DksA2, a zinc-independent structural analog of the transcription factor DksA. Furman R, et al. FEBS Lett, 2013 Mar 18. PMID 23416301, Free PMC Article
  2. Role of a Zn-independent DksA in Zn homeostasis and stringent response. Blaby-Haas CE, et al. Mol Microbiol, 2011 Feb. PMID 21255113, Free PMC Article
  3. Proteomic, microarray, and signature-tagged mutagenesis analyses of anaerobic Pseudomonas aeruginosa at pH 6.5, likely representing chronic, late-stage cystic fibrosis airway conditions. Platt MD, et al. J Bacteriol, 2008 Apr. PMID 18203836, Free PMC Article
  4. DksA represses ribosomal gene transcription in Pseudomonas aeruginosa by interacting with RNA polymerase on ribosomal promoters. Perron K, et al. Mol Microbiol, 2005 May. PMID 15853892
  5. Inhibition of quorum sensing by a Pseudomonas aeruginosa dksA homologue. Branny P, et al. J Bacteriol, 2001 Mar. PMID 11160083, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. DksA2 plays a role in Zn homeostasis and serves as a back-up copy of the canonical Zn-dependent DksA in Zn-poor environments.
    Title: Role of a Zn-independent DksA in Zn homeostasis and stringent response.
  2. Data show that DksA is a negative regulator of ribosomal RNA transcription during exponential growth and stringent conditions.
    Title: DksA represses ribosomal gene transcription in Pseudomonas aeruginosa by interacting with RNA polymerase on ribosomal promoters.
Submit: New GeneRIF Correction

Homology

Gene Ontology Provided by PseudoCAP

Function Evidence Code Pubs
enables RNA polymerase binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in negative regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of lipid biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of proteolysis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of cellular respiration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of gene expression IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
suppressor protein DksA
NP_253411.1
  • Product name confidence: class 1 (Function experimentally demonstrated in P. aeruginosa)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_002516.2 Reference assembly

    Range
    5302386..5302832
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_253411.1 suppressor protein DksA [Pseudomonas aeruginosa PAO1]

    See identical proteins and their annotated locations for NP_253411.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    G3XD14, Q9KKG5
    Conserved Domains (1) summary
    cl00755
    Location:16 → 147
    zf-dskA_traR; Prokaryotic dksA/traR C4-type zinc finger
Nucleotide Protein
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