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DPM1 dolichyl-phosphate mannosyltransferase subunit 1, catalytic [ Homo sapiens (human) ]

Gene ID: 8813, updated on 12-Aug-2018

Summary

Official Symbol
DPM1provided by HGNC
Official Full Name
dolichyl-phosphate mannosyltransferase subunit 1, catalyticprovided by HGNC
Primary source
HGNC:HGNC:3005
See related
Ensembl:ENSG00000000419 MIM:603503; Vega:OTTHUMG00000032742
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MPDS; CDGIE
Summary
Dolichol-phosphate mannose (Dol-P-Man) serves as a donor of mannosyl residues on the lumenal side of the endoplasmic reticulum (ER). Lack of Dol-P-Man results in defective surface expression of GPI-anchored proteins. Dol-P-Man is synthesized from GDP-mannose and dolichol-phosphate on the cytosolic side of the ER by the enzyme dolichyl-phosphate mannosyltransferase. Human DPM1 lacks a carboxy-terminal transmembrane domain and signal sequence and is regulated by DPM2. Mutations in this gene are associated with congenital disorder of glycosylation type Ie. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2015]
Expression
Ubiquitous expression in adrenal (RPKM 24.6), thyroid (RPKM 23.5) and 25 other tissues See more
Orthologs

Genomic context

See DPM1 in Genome Data Viewer
Location:
20q13.13
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 20 NC_000020.11 (50934855..50958564, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (49551404..49575081, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene breast carcinoma amplified sequence 4 Neighboring gene TMSB4X pseudogene 6 Neighboring gene activity dependent neuroprotector homeobox Neighboring gene proteasome 26S subunit, non-ATPase, 10 pseudogene 1 Neighboring gene ADNP antisense RNA 1 Neighboring gene molybdenum cofactor synthesis 3 Neighboring gene potassium voltage-gated channel modifier subfamily G member 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit (DPM1) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
dolichyl-phosphate beta-D-mannosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
dolichyl-phosphate beta-D-mannosyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
dolichyl-phosphate-mannose-protein mannosyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
GPI anchor biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
GPI anchor biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
dolichol metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
dolichol metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
protein O-linked mannosylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein O-linked mannosylation IDA
Inferred from Direct Assay
more info
PubMed 
protein mannosylation IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
dolichol-phosphate-mannose synthase complex IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
membrane HDA PubMed 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
nucleus HDA PubMed 

General protein information

Preferred Names
dolichol-phosphate mannosyltransferase subunit 1
Names
DPM synthase complex, catalytic subunit
DPM synthase subunit 1
MPD synthase subunit 1
dolichol monophosphate mannose synthase
dolichol-phosphate mannose synthase subunit 1
dolichyl-phosphate beta-D-mannosyltransferase subunit 1
dolichyl-phosphate mannosyltransferase polypeptide 1 catalytic subunit
mannose-P-dolichol synthase subunit 1
NP_001303963.1
NP_001303964.1
NP_001303965.1
NP_003850.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_008923.1 RefSeqGene

    Range
    4960..28669
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001317034.1NP_001303963.1  dolichol-phosphate mannosyltransferase subunit 1 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AL034553, BC007073, CA865473, DR156925
    UniProtKB/Swiss-Prot
    O60762
    Related
    ENSP00000360640.4, OTTHUMP00000031286, ENST00000371584.8, OTTHUMT00000079718
    Conserved Domains (3) summary
    cd06442
    Location:29291
    DPM1_like; DPM1_like represents putative enzymes similar to eukaryotic DPM1
    PLN02726
    Location:23295
    PLN02726; dolichyl-phosphate beta-D-mannosyltransferase
    pfam13900
    Location:175206
    GVQW; Putative domain of unknown function
  2. NM_001317035.1NP_001303964.1  dolichol-phosphate mannosyltransferase subunit 1 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AL034553, BC007073, BM922866, CA865473
    Consensus CDS
    CCDS82628.1
    UniProtKB/Swiss-Prot
    O60762
    UniProtKB/TrEMBL
    Q5QPK2
    Related
    ENSP00000360638.4, OTTHUMP00000031288, ENST00000371582.8, OTTHUMT00000079720
    Conserved Domains (2) summary
    cd06442
    Location:29283
    DPM1_like; DPM1_like represents putative enzymes similar to eukaryotic DPM1
    PLN02726
    Location:23287
    PLN02726; dolichyl-phosphate beta-D-mannosyltransferase
  3. NM_001317036.1NP_001303965.1  dolichol-phosphate mannosyltransferase subunit 1 isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks two alternate in-frame exons in the 3' coding region, compared to variant 1. The encoded isoform (4) is shorter than isoform 1.
    Source sequence(s)
    AL034553, BC007073, BQ441542, CA865473
    UniProtKB/Swiss-Prot
    O60762
    Conserved Domains (2) summary
    cd06442
    Location:29233
    DPM1_like; DPM1_like represents putative enzymes similar to eukaryotic DPM1
    PLN02726
    Location:23237
    PLN02726; dolichyl-phosphate beta-D-mannosyltransferase
  4. NM_003859.2NP_003850.1  dolichol-phosphate mannosyltransferase subunit 1 isoform 3

    See identical proteins and their annotated locations for NP_003850.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
    Source sequence(s)
    AL034553, BC007073, CA865473
    Consensus CDS
    CCDS13434.1
    UniProtKB/Swiss-Prot
    O60762
    UniProtKB/TrEMBL
    A0A0S2Z4Y5
    Related
    ENSP00000360644.5, OTTHUMP00000031285, ENST00000371588.9, OTTHUMT00000079716
    Conserved Domains (1) summary
    PLN02726
    Location:23260
    PLN02726; dolichyl-phosphate beta-D-mannosyltransferase

RNA

  1. NR_133648.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks an alternate internal exon, and uses an alternate splice site in an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AL034553, BC008427
    Related
    ENST00000466152.5

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p12 Primary Assembly

    Range
    50934855..50958564 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_002958551.1 RNA Sequence

  2. XR_002958550.1 RNA Sequence

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