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msrA peptide methionine sulfoxide reductase [ Pseudomonas aeruginosa PAO1 ]

Gene ID: 881240, updated on 24-Aug-2024

Summary

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Gene symbol
msrA
Gene description
peptide methionine sulfoxide reductase
Locus tag
PA5018
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Pseudomonas aeruginosa PAO1 (strain: PAO1)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas
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Genomic context

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Sequence:
NC_002516.2 (5643803..5644450)

NC_002516.2Genomic Context describing neighboring genes Neighboring gene dihydrolipoamide acetyltransferase Neighboring gene hypothetical protein Neighboring gene hypothetical protein Neighboring gene acyl-CoA dehydrogenase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_002516.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Gene expression and physiological role of Pseudomonas aeruginosa methionine sulfoxide reductases during oxidative stress. Romsang A, et al. J Bacteriol, 2013 Aug. PMID 23687271, Free PMC Article
  2. Pseudomonas Genome Database: facilitating user-friendly, comprehensive comparisons of microbial genomes. Winsor GL, et al. Nucleic Acids Res, 2009 Jan. PMID 18978025, Free PMC Article
  3. Defining the Pseudomonas aeruginosa SOS response and its role in the global response to the antibiotic ciprofloxacin. Cirz RT, et al. J Bacteriol, 2006 Oct. PMID 17015649, Free PMC Article
  4. Cystic fibrosis sputum supports growth and cues key aspects of Pseudomonas aeruginosa physiology. Palmer KL, et al. J Bacteriol, 2005 Aug. PMID 16030221, Free PMC Article
  5. A cystic fibrosis epidemic strain of Pseudomonas aeruginosa displays enhanced virulence and antimicrobial resistance. Salunkhe P, et al. J Bacteriol, 2005 Jul. PMID 15995206, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The data indicate that msrA and msrB are essential genes for oxidative stress protection and bacterial virulence.
    Title: Gene expression and physiological role of Pseudomonas aeruginosa methionine sulfoxide reductases during oxidative stress.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by PseudoCAP

Function Evidence Code Pubs
enables peptide-methionine (S)-S-oxide reductase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cellular response to oxidative stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to hypochlorite IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
peptide methionine sulfoxide reductase
NP_253705.1
  • Product name confidence: class 2 (High similarity to functionally studied protein)

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_002516.2 Reference assembly

    Range
    5643803..5644450
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_253705.1 peptide methionine sulfoxide reductase [Pseudomonas aeruginosa PAO1]

    See identical proteins and their annotated locations for NP_253705.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    Q9HUF1
    Conserved Domains (1) summary
    PRK00058
    Location:5 → 214
    PRK00058; peptide-methionine (S)-S-oxide reductase MsrA
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9HUF1.1

Gene LinkOut

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Molecular Biology Databases
Research Materials