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ampD N-acetyl-anhydromuranmyl-L-alanine amidase [ Pseudomonas aeruginosa PAO1 ]

Gene ID: 881105, updated on 30-Jul-2025
Gene symbol
ampD
Gene description
N-acetyl-anhydromuranmyl-L-alanine amidase
Locus tag
PA4522
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Pseudomonas aeruginosa PAO1 (strain: PAO1)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas
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Sequence:
NC_002516.2 (5064774..5065340, complement)

NC_002516.2Genomic Context describing neighboring genes Neighboring gene ornithine decarboxylase Neighboring gene chemotaxis transducer Neighboring gene hypothetical protein Neighboring gene hypothetical protein Neighboring gene nicotinate-nucleotide pyrophosphorylase

Genomic Sequence:
NC_002516.2

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Elucidation of Mechanisms of Ceftazidime Resistance among Clinical Isolates of Pseudomonas aeruginosa by Using Genomic Data. Kos VN, et al. Antimicrob Agents Chemother, 2016 Jun. PMID 27067331, Free PMC Article
  2. NagZ inactivation prevents and reverts beta-lactam resistance, driven by AmpD and PBP 4 mutations, in Pseudomonas aeruginosa. Zamorano L, et al. Antimicrob Agents Chemother, 2010 Sep. PMID 20566764, Free PMC Article
  3. An ampD gene in Pseudomonas aeruginosa encodes a negative regulator of AmpC beta-lactamase expression. Langaee TY, et al. Antimicrob Agents Chemother, 1998 Dec. PMID 9835532, Free PMC Article
  4. Pseudomonas Genome Database: facilitating user-friendly, comprehensive comparisons of microbial genomes. Winsor GL, et al. Nucleic Acids Res, 2009 Jan. PMID 18978025, Free PMC Article
  5. Defining the Pseudomonas aeruginosa SOS response and its role in the global response to the antibiotic ciprofloxacin. Cirz RT, et al. J Bacteriol, 2006 Oct. PMID 17015649, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Changes have been identified within AmpD responsible for derepression of ampC and conferring ceftazidime resistance.
    Title: Elucidation of Mechanisms of Ceftazidime Resistance among Clinical Isolates of Pseudomonas aeruginosa by Using Genomic Data.
  2. NagZ restored the wild-type beta-lactam MICs and ampC expression of PAO1 dacB and ampD mutants and dramatically reduced the MICs and the level of ampC expression in the dacB-ampD double mutant.
    Title: NagZ inactivation prevents and reverts beta-lactam resistance, driven by AmpD and PBP 4 mutations, in Pseudomonas aeruginosa.
Submit: New GeneRIF Correction

Homology

Gene Ontology Provided by PseudoCAP

Function Evidence Code Pubs
enables N-acetylmuramoyl-L-alanine amidase activity IEA
Inferred from Electronic Annotation
more info
  
enables N-acetylmuramoyl-L-alanine amidase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell wall organization IEA
Inferred from Electronic Annotation
more info
  
involved_in peptidoglycan catabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Gram-negative-bacterium-type cell wall IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
N-acetyl-anhydromuranmyl-L-alanine amidase
NP_253212.1
  • Product name confidence: class 2 (High similarity to functionally studied protein)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_002516.2 Reference assembly

    Range
    5064774..5065340 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_253212.1 N-acetyl-anhydromuranmyl-L-alanine amidase [Pseudomonas aeruginosa PAO1]

    See identical proteins and their annotated locations for NP_253212.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    G3XCW9, Q9ZGA0
    Conserved Domains (1) summary
    PRK11789
    Location:1 → 186
    PRK11789; 1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD
Nucleotide Protein
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