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PA4608 hypothetical protein [ Pseudomonas aeruginosa PAO1 ]

Gene ID: 881102, updated on 23-Apr-2026
Gene symbol
PA4608
Gene description
hypothetical protein
Locus tag
PA4608
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Pseudomonas aeruginosa PAO1 (strain: PAO1)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas
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Sequence:
NC_002516.2 (5166900..5167277)

NC_002516.2Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene hypothetical protein Neighboring gene DNA repair protein RadA Neighboring gene hypothetical protein

Genomic Sequence:
NC_002516.2

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Solution structure of the PilZ domain protein PA4608 complex with cyclic di-GMP identifies charge clustering as molecular readout. Habazettl J, et al. J Biol Chem, 2011 Apr 22. PMID 21310957, Free PMC Article
  2. Diguanylate Cyclases and Phosphodiesterases Required for Basal-Level c-di-GMP in Pseudomonas aeruginosa as Revealed by Systematic Phylogenetic and Transcriptomic Analyses. Wei Q, et al. Appl Environ Microbiol, 2019 Nov 1. PMID 31444209, Free PMC Article
  3. Structural characterization reveals that a PilZ domain protein undergoes substantial conformational change upon binding to cyclic dimeric guanosine monophosphate. Shin JS, et al. Protein Sci, 2011 Feb. PMID 21280119, Free PMC Article
  4. NMR structure and binding studies confirm that PA4608 from Pseudomonas aeruginosa is a PilZ domain and a c-di-GMP binding protein. Ramelot TA, et al. Proteins, 2007 Feb 1. PMID 17096419
  5. Structural basis for the regulation of chemotaxis by MapZ in the presence of c-di-GMP. Zhu Y, et al. Acta Crystallogr D Struct Biol, 2017 Aug 1. PMID 28777083

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Cyclic-di-GMP (c-di-GMP) is an important second messenger involved in the regulation of biofilm formation. Among 40 c-di-GMP metabolizing genes, 5 have well-conserved phylogenetic distribution and invariable expression profiles, suggesting that there are enzymes required for the basal level of c-di-GMP in P. aeruginosa.
    Title: Diguanylate Cyclases and Phosphodiesterases Required for Basal-Level c-di-GMP in Pseudomonas aeruginosa as Revealed by Systematic Phylogenetic and Transcriptomic Analyses.
  2. Recently, a single-domain PilZ protein, MapZ (PA4608), was identified to inhibit the activity of the methyltransferase CheR1. Here, crystal structures of the C-terminal domain of CheR1 containing S-adenosylhomocysteine and of CheR1 in complex with c-di-GMP-bound MapZ are reported.
    Title: Structural basis for the regulation of chemotaxis by MapZ in the presence of c-di-GMP.
  3. Determined the solution structure of c-di-GMP bound PA4608. We found that PA4608 undergoes conformational changes to expose the c-di-GMP binding site by ejection of the C-terminal 3(10) helix.
    Title: Structural characterization reveals that a PilZ domain protein undergoes substantial conformational change upon binding to cyclic dimeric guanosine monophosphate.
  4. The monomeric core of PA4608 has a 6-stranded antiparallel beta barrel flanked by 3 helices. Conserved surface residues of PA4608 homologs show c-di-GMP binding site is at 1 end of the barrel & has residues in the helices & the unstructured N-terminus.
    Title: NMR structure and binding studies confirm that PA4608 from Pseudomonas aeruginosa is a PilZ domain and a c-di-GMP binding protein.
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Homology

Gene Ontology Provided by PseudoCAP

Function Evidence Code Pubs
enables cyclic-di-GMP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables cyclic-di-GMP binding IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
hypothetical protein
NP_253298.1
  • 'Product name confidence: class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences)'

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_002516.2 Reference assembly

    Range
    5166900..5167277
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_253298.1 hypothetical protein PA4608 [Pseudomonas aeruginosa PAO1]

    See identical proteins and their annotated locations for NP_253298.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    Q9HVI1
    Conserved Domains (1) summary
    pfam07238
    Location:7 → 103
    PilZ; PilZ domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9HVI1.1

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