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morA motility regulator [ Pseudomonas aeruginosa PAO1 ]

Gene ID: 881084, updated on 19-Nov-2025
Gene symbol
morA
Gene description
motility regulator
Locus tag
PA4601
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Pseudomonas aeruginosa PAO1 (strain: PAO1)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas
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Sequence:
NC_002516.2 (5156368..5160615)

NC_002516.2Genomic Context describing neighboring genes Neighboring gene resistance-nodulation-cell division (RND) multidrug efflux membrane fusion protein MexC Neighboring gene transcriptional regulator NfxB Neighboring gene serine hydroxymethyltransferase Neighboring gene hypothetical protein

Genomic Sequence:
NC_002516.2

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Global Regulator MorA Affects Virulence-Associated Protease Secretion in Pseudomonas aeruginosa PAO1. Ravichandran A, et al. PLoS One, 2015. PMID 25894344, Free PMC Article
  2. MorA defines a new class of regulators affecting flagellar development and biofilm formation in diverse Pseudomonas species. Choy WK, et al. J Bacteriol, 2004 Nov. PMID 15489433, Free PMC Article
  3. Formation and dimerization of the phosphodiesterase active site of the Pseudomonas aeruginosa MorA, a bi-functional c-di-GMP regulator. Phippen CW, et al. FEBS Lett, 2014 Dec 20. PMID 25447517
  4. Pseudomonas Genome Database: facilitating user-friendly, comprehensive comparisons of microbial genomes. Winsor GL, et al. Nucleic Acids Res, 2009 Jan. PMID 18978025, Free PMC Article
  5. Defining the Pseudomonas aeruginosa SOS response and its role in the global response to the antibiotic ciprofloxacin. Cirz RT, et al. J Bacteriol, 2006 Oct. PMID 17015649, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MorA, a global regulator with GGDEF and EAL domains that was previously reported to affect virulence factors, negatively regulates protease secretion via the type II secretion system (T2SS) in P. aeruginosa PAO1.
    Title: Global Regulator MorA Affects Virulence-Associated Protease Secretion in Pseudomonas aeruginosa PAO1.
  2. dimerization of the phosphodiesterase active site of the Pseudomonas aeruginosa MorA
    Title: Formation and dimerization of the phosphodiesterase active site of the Pseudomonas aeruginosa MorA, a bi-functional c-di-GMP regulator.
  3. novel membrane-localized regulator that impairs biofilm formation
    Title: MorA defines a new class of regulators affecting flagellar development and biofilm formation in diverse Pseudomonas species.
Submit: New GeneRIF Correction

Homology

Gene Ontology Provided by PseudoCAP

Function Evidence Code Pubs
enables cyclic-guanylate-specific phosphodiesterase activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cellular response to nitric oxide IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
motility regulator
NP_253291.1
  • Product name confidence: class 1 (Function experimentally demonstrated in P. aeruginosa)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_002516.2 Reference assembly

    Range
    5156368..5160615
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_253291.1 motility regulator [Pseudomonas aeruginosa PAO1]

    See identical proteins and their annotated locations for NP_253291.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    Q9HVI8
    Conserved Domains (4) summary
    PRK13560
    Location:518 → 974
    PRK13560; hypothetical protein; Provisional
    COG5000
    Location:269 → 374
    NtrY; Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]
    PRK10060
    Location:838 → 1406
    PRK10060; cyclic di-GMP phosphodiesterase
    pfam08447
    Location:618 → 699
    PAS_3; PAS fold
Nucleotide Protein
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