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mexC resistance-nodulation-cell division (RND) multidrug efflux membrane fusion protein MexC [ Pseudomonas aeruginosa PAO1 ]

Gene ID: 881078, updated on 24-Aug-2024

Summary

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Gene symbol
mexC
Gene description
resistance-nodulation-cell division (RND) multidrug efflux membrane fusion protein MexC
Locus tag
PA4599
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Pseudomonas aeruginosa PAO1 (strain: PAO1)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas
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Genomic context

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Sequence:
NC_002516.2 (5154237..5155400, complement)

NC_002516.2Genomic Context describing neighboring genes Neighboring gene multidrug efflux outer membrane protein OprJ Neighboring gene resistance-nodulation-cell division (RND) multidrug efflux transporter MexD Neighboring gene transcriptional regulator NfxB Neighboring gene motility regulator

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_002516.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Overexpression of the multidrug efflux pumps MexCD-OprJ and MexEF-OprN is associated with a reduction of type III secretion in Pseudomonas aeruginosa. Linares JF, et al. J Bacteriol, 2005 Feb. PMID 15687203, Free PMC Article
  2. Pseudomonas Genome Database: facilitating user-friendly, comprehensive comparisons of microbial genomes. Winsor GL, et al. Nucleic Acids Res, 2009 Jan. PMID 18978025, Free PMC Article
  3. Defining the Pseudomonas aeruginosa SOS response and its role in the global response to the antibiotic ciprofloxacin. Cirz RT, et al. J Bacteriol, 2006 Oct. PMID 17015649, Free PMC Article
  4. Cystic fibrosis sputum supports growth and cues key aspects of Pseudomonas aeruginosa physiology. Palmer KL, et al. J Bacteriol, 2005 Aug. PMID 16030221, Free PMC Article
  5. A cystic fibrosis epidemic strain of Pseudomonas aeruginosa displays enhanced virulence and antimicrobial resistance. Salunkhe P, et al. J Bacteriol, 2005 Jul. PMID 15995206, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. results presented here indicate that the transcriptional activation of the T3S regulon is reduced in mutants overexpressing either the MexCD-OprJ or MexEF-OprN MDR pump, making these mutants less cytotoxic
    Title: Overexpression of the multidrug efflux pumps MexCD-OprJ and MexEF-OprN is associated with a reduction of type III secretion in Pseudomonas aeruginosa.
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General gene information

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Homology

General protein information

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Preferred Names
resistance-nodulation-cell division (RND) multidrug efflux membrane fusion protein MexC
NP_253289.1
  • Product name confidence: class 1 (Function experimentally demonstrated in P. aeruginosa)

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_002516.2 Reference assembly

    Range
    5154237..5155400 complement
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    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_253289.1 resistance-nodulation-cell division (RND) multidrug efflux membrane fusion protein MexC [Pseudomonas aeruginosa PAO1]

    See identical proteins and their annotated locations for NP_253289.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A367M9I7
    Conserved Domains (1) summary
    NF033138
    Location:1 → 375
    RND-peri-MexC; MexC family multidrug efflux RND transporter periplasmic adaptor subunit
Nucleotide Protein
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