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mexC resistance-nodulation-cell division (RND) multidrug efflux membrane fusion protein MexC [ Pseudomonas aeruginosa PAO1 ]

Gene ID: 881078, updated on 12-Aug-2026
Gene symbol
mexC
Gene description
resistance-nodulation-cell division (RND) multidrug efflux membrane fusion protein MexC
Locus tag
PA4599
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Pseudomonas aeruginosa PAO1 (strain: PAO1)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas
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Sequence:
NC_002516.2 (5154237..5155400, complement)

NC_002516.2Genomic Context describing neighboring genes Neighboring gene multidrug efflux outer membrane protein OprJ Neighboring gene resistance-nodulation-cell division (RND) multidrug efflux transporter MexD Neighboring gene transcriptional regulator NfxB Neighboring gene motility regulator

Genomic Sequence:
NC_002516.2

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Induction of mexCD-oprJ operon for a multidrug efflux pump by disinfectants in wild-type Pseudomonas aeruginosa PAO1. Morita Y, et al. J Antimicrob Chemother, 2003 Apr. PMID 12654738
  2. Overexpression of the multidrug efflux pumps MexCD-OprJ and MexEF-OprN is associated with a reduction of type III secretion in Pseudomonas aeruginosa. Linares JF, et al. J Bacteriol, 2005 Feb. PMID 15687203, Free PMC Article
  3. Pseudomonas Genome Database: facilitating user-friendly, comprehensive comparisons of microbial genomes. Winsor GL, et al. Nucleic Acids Res, 2009 Jan. PMID 18978025, Free PMC Article
  4. Defining the Pseudomonas aeruginosa SOS response and its role in the global response to the antibiotic ciprofloxacin. Cirz RT, et al. J Bacteriol, 2006 Oct. PMID 17015649, Free PMC Article
  5. Cystic fibrosis sputum supports growth and cues key aspects of Pseudomonas aeruginosa physiology. Palmer KL, et al. J Bacteriol, 2005 Aug. PMID 16030221, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. results presented here indicate that the transcriptional activation of the T3S regulon is reduced in mutants overexpressing either the MexCD-OprJ or MexEF-OprN MDR pump, making these mutants less cytotoxic
    Title: Overexpression of the multidrug efflux pumps MexCD-OprJ and MexEF-OprN is associated with a reduction of type III secretion in Pseudomonas aeruginosa.
Submit: New GeneRIF Correction

Homology

Gene Ontology Provided by PseudoCAP

Function Evidence Code Pubs
enables efflux transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane transporter activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in response to antibiotic IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to antibiotic IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in transmembrane transport IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in xenobiotic detoxification by transmembrane export across the cell outer membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
resistance-nodulation-cell division (RND) multidrug efflux membrane fusion protein MexC
NP_253289.1
  • Product name confidence: class 1 (Function experimentally demonstrated in P. aeruginosa)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_002516.2 Reference assembly

    Range
    5154237..5155400 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_253289.1 resistance-nodulation-cell division (RND) multidrug efflux membrane fusion protein MexC [Pseudomonas aeruginosa PAO1]

    See identical proteins and their annotated locations for NP_253289.1

    Status: PROVISIONAL

    Conserved Domains (1) summary
    NF033138
    Location:1 → 375
    RND-peri-MexC; MexC family multidrug efflux RND transporter periplasmic adaptor subunit
Nucleotide Protein
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