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mexD resistance-nodulation-cell division (RND) multidrug efflux transporter MexD [ Pseudomonas aeruginosa PAO1 ]

Gene ID: 881071, updated on 24-Aug-2024
Gene symbol
mexD
Gene description
resistance-nodulation-cell division (RND) multidrug efflux transporter MexD
Locus tag
PA4598
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Pseudomonas aeruginosa PAO1 (strain: PAO1)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas
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Sequence:
NC_002516.2 (5151078..5154209, complement)

NC_002516.2Genomic Context describing neighboring genes Neighboring gene transcriptional regulator Neighboring gene multidrug efflux outer membrane protein OprJ Neighboring gene resistance-nodulation-cell division (RND) multidrug efflux membrane fusion protein MexC Neighboring gene transcriptional regulator NfxB

Genomic Sequence:
NC_002516.2

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Induction of mexCD-oprJ operon for a multidrug efflux pump by disinfectants in wild-type Pseudomonas aeruginosa PAO1. Morita Y, et al. J Antimicrob Chemother, 2003 Apr. PMID 12654738
  2. Sub-inhibitory concentrations of antibiotics and wastewater influencing biofilm formation and gene expression of multi-resistant Pseudomonas aeruginosa wastewater isolates. Bruchmann J, et al. Environ Sci Pollut Res Int, 2013 Jun. PMID 23392972
  3. Overexpression of the multidrug efflux pumps MexCD-OprJ and MexEF-OprN is associated with a reduction of type III secretion in Pseudomonas aeruginosa. Linares JF, et al. J Bacteriol, 2005 Feb. PMID 15687203, Free PMC Article
  4. Pseudomonas Genome Database: facilitating user-friendly, comprehensive comparisons of microbial genomes. Winsor GL, et al. Nucleic Acids Res, 2009 Jan. PMID 18978025, Free PMC Article
  5. Defining the Pseudomonas aeruginosa SOS response and its role in the global response to the antibiotic ciprofloxacin. Cirz RT, et al. J Bacteriol, 2006 Oct. PMID 17015649, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Subinhibitory concentrations of macrolides specifically upregulated expression of quorum sensing genes (rhlR, lasI), whereas sulfonamides and municipal wastewater, instead upregulated expression of specific resistant genes (sul1) and efflux pumps (mexD).
    Title: Sub-inhibitory concentrations of antibiotics and wastewater influencing biofilm formation and gene expression of multi-resistant Pseudomonas aeruginosa wastewater isolates.
  2. results presented here indicate that the transcriptional activation of the T3S regulon is reduced in mutants overexpressing either the MexCD-OprJ or MexEF-OprN MDR pump, making these mutants less cytotoxic
    Title: Overexpression of the multidrug efflux pumps MexCD-OprJ and MexEF-OprN is associated with a reduction of type III secretion in Pseudomonas aeruginosa.
  3. The MexCD-OprJ operon is induced by some disinfectants and cytotoxic agents. Cells showed increased resistance to norfloxacin when grown in the presence of the inducers of the operon.
    Title: Induction of mexCD-oprJ operon for a multidrug efflux pump by disinfectants in wild-type Pseudomonas aeruginosa PAO1.
Submit: New GeneRIF Correction

Homology

Preferred Names
resistance-nodulation-cell division (RND) multidrug efflux transporter MexD
NP_253288.1
  • Product name confidence: class 1 (Function experimentally demonstrated in P. aeruginosa)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_002516.2 Reference assembly

    Range
    5151078..5154209 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_253288.1 resistance-nodulation-cell division (RND) multidrug efflux transporter MexD [Pseudomonas aeruginosa PAO1]

    See identical proteins and their annotated locations for NP_253288.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    Q51396
    Conserved Domains (1) summary
    TIGR00915
    Location:1 → 1038
    2A0602; The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family
Nucleotide Protein
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