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pilN type 4 fimbrial biogenesis protein PilN [ Pseudomonas aeruginosa PAO1 ]

Gene ID: 881025, updated on 24-Aug-2024

Summary

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Gene symbol
pilN
Gene description
type 4 fimbrial biogenesis protein PilN
Locus tag
PA5043
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Pseudomonas aeruginosa PAO1 (strain: PAO1)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas
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Genomic context

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Sequence:
NC_002516.2 (5679053..5679649, complement)

NC_002516.2Genomic Context describing neighboring genes Neighboring gene type 4 fimbrial biogenesis outer membrane protein PilQ Neighboring gene type 4 fimbrial biogenesis protein PilP Neighboring gene type 4 fimbrial biogenesis protein PilO Neighboring gene type 4 fimbrial biogenesis protein PilM Neighboring gene penicillin-binding protein 1A

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_002516.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. PilN Binding Modulates the Structure and Binding Partners of the Pseudomonas aeruginosa Type IVa Pilus Protein PilM. McCallum M, et al. J Biol Chem, 2016 May 20. PMID 27022027, Free PMC Article
  2. Periplasmic domains of Pseudomonas aeruginosa PilN and PilO form a stable heterodimeric complex. Sampaleanu LM, et al. J Mol Biol, 2009 Nov 20. PMID 19857646
  3. PilMNOPQ from the Pseudomonas aeruginosa type IV pilus system form a transenvelope protein interaction network that interacts with PilA. Tammam S, et al. J Bacteriol, 2013 May. PMID 23457250, Free PMC Article
  4. Type IV Pilus Alignment Subcomplex Proteins PilN and PilO Form Homo- and Heterodimers in Vivo. Leighton TL, et al. J Biol Chem, 2016 Sep 16. PMID 27474743, Free PMC Article
  5. Characterization of the PilN, PilO and PilP type IVa pilus subcomplex. Tammam S, et al. Mol Microbiol, 2011 Dec. PMID 22053789

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. data suggest that T4P function depends on rearrangements at PilN and PilO interfaces.
    Title: Type IV Pilus Alignment Subcomplex Proteins PilN and PilO Form Homo- and Heterodimers in Vivo.
  2. Structural analysis, multiangle light scattering coupled with size exclusion chromatography, and bacterial two-hybrid data revealed that PilM forms dimers mediated by the binding of a novel conserved motif in the N terminus of PilM, and binding PilN abrogates this binding interface, resulting in PilM monomerization.
    Title: PilN Binding Modulates the Structure and Binding Partners of the Pseudomonas aeruginosa Type IVa Pilus Protein PilM.
  3. PilP interacts with the N0 segment of PilQ via its C-terminal domain, and that the N-terminal cytoplasmic tail of PilN binds to the actin-like protein PilM, connecting all cellular compartments via the PilMNOPQ protein interaction network.
    Title: PilMNOPQ from the Pseudomonas aeruginosa type IV pilus system form a transenvelope protein interaction network that interacts with PilA.
  4. PilN, PilO and PilP interact directly to form a stable heterotrimeric complex.
    Title: Characterization of the PilN, PilO and PilP type IVa pilus subcomplex.
  5. PilN/O heterodimers form the foundation of the inner-membrane PilM/N/O/P complex, which is critical for the assembly of a functional type IV pili complex.
    Title: Periplasmic domains of Pseudomonas aeruginosa PilN and PilO form a stable heterodimeric complex.
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General gene information

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Homology

Gene Ontology Provided by PseudoCAP

Process Evidence Code Pubs
acts_upstream_of_or_within type IV pilus assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within type IV pilus-dependent motility IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in type IV pilus IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
type 4 fimbrial biogenesis protein PilN
NP_253730.1
  • Product name confidence: class 1 (Function experimentally demonstrated in P. aeruginosa)

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_002516.2 Reference assembly

    Range
    5679053..5679649 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_253730.1 type 4 fimbrial biogenesis protein PilN [Pseudomonas aeruginosa PAO1]

    See identical proteins and their annotated locations for NP_253730.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    G3XD30, Q51352
    Conserved Domains (1) summary
    COG3166
    Location:1 → 198
    PilN; Tfp pilus assembly protein PilN [Cell motility, Extracellular structures]
Nucleotide Protein
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