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IL1RL2 interleukin 1 receptor like 2 [ Homo sapiens (human) ]

Gene ID: 8808, updated on 22-Aug-2020

Summary

Official Symbol
IL1RL2provided by HGNC
Official Full Name
interleukin 1 receptor like 2provided by HGNC
Primary source
HGNC:HGNC:5999
See related
Ensembl:ENSG00000115598 MIM:604512
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IL-36R; IL1RRP2; IL-1Rrp2; IL1R-rp2
Summary
The protein encoded by this gene is a member of the interleukin 1 receptor family. An experiment with transient gene expression demonstrated that this receptor was incapable of binding to interleukin 1 alpha and interleukin 1 beta with high affinity. This gene and four other interleukin 1 receptor family genes, including interleukin 1 receptor, type I (IL1R1), interleukin 1 receptor, type II (IL1R2), interleukin 1 receptor-like 1 (IL1RL1), and interleukin 18 receptor 1 (IL18R1), form a cytokine receptor gene cluster in a region mapped to chromosome 2q12. [provided by RefSeq, Jul 2008]
Expression
Biased expression in skin (RPKM 3.4), esophagus (RPKM 1.6) and 11 other tissues See more
Orthologs

Genomic context

See IL1RL2 in Genome Data Viewer
Location:
2q12.1
Exon count:
15
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (102186973..102242910)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (102803433..102856462)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107985926 Neighboring gene interleukin 1 receptor type 1 Neighboring gene Sharpr-MPRA regulatory regions 1871 and 11985 Neighboring gene family with sequence similarity 183 member D, pseudogene Neighboring gene interleukin 1 receptor like 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci.
GeneReviews: Not available
Common genetic variation at the IL1RL1 locus regulates IL-33/ST2 signaling.
GeneReviews: Not available
Genome-wide association of body fat distribution in African ancestry populations suggests new loci.
GeneReviews: Not available
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
GeneReviews: Not available
Multiple common variants for celiac disease influencing immune gene expression.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
NAD(P)+ nucleosidase activity IEA
Inferred from Electronic Annotation
more info
 
NAD+ nucleotidase, cyclic ADP-ribose generating IEA
Inferred from Electronic Annotation
more info
 
interleukin-1 receptor activity TAS
Traceable Author Statement
more info
PubMed 
interleukin-1, type I, activating receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cellular defense response TAS
Traceable Author Statement
more info
PubMed 
cellular response to cytokine stimulus TAS
Traceable Author Statement
more info
 
cytokine-mediated signaling pathway TAS
Traceable Author Statement
more info
 
inflammatory response IEA
Inferred from Electronic Annotation
more info
 
innate immune response IEA
Inferred from Electronic Annotation
more info
 
interleukin-1-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
positive regulation of T cell differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of interleukin-6 production IEA
Inferred from Electronic Annotation
more info
 
regulation of inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
interleukin-1 receptor-like 2
Names
IL-1 receptor-related protein 2
IL-36 receptor
interleukin-1 receptor-related protein 2
NP_001338375.1
NP_001338376.1
NP_001338377.1
NP_001338378.1
NP_001338379.1
NP_003845.2
XP_006712883.1
XP_006712885.1
XP_011510393.1
XP_011510394.1
XP_011510395.1
XP_011510396.1
XP_011510398.1
XP_016860663.1
XP_016860664.1
XP_016860665.1
XP_016860666.1
XP_016860669.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001351446.2NP_001338375.1  interleukin-1 receptor-like 2 isoform a precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2), as well as variant 1, encodes the longest isoform (a).
    Source sequence(s)
    AC007248, AK315334, BC107064, CA448166
    Consensus CDS
    CCDS2056.1
    Conserved Domains (3) summary
    pfam01582
    Location:386536
    TIR; TIR domain
    cd05757
    Location:130218
    Ig2_IL1R_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
    cl11960
    Location:26112
    Ig; Immunoglobulin domain
  2. NM_001351447.1NP_001338376.1  interleukin-1 receptor-like 2 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) encodes isoform b.
    Source sequence(s)
    AC007271, AF284434, BC107064, CA448166
    Consensus CDS
    CCDS86867.1
    Related
    ENSP00000413348.2, ENST00000441515.3
    Conserved Domains (2) summary
    pfam01582
    Location:268418
    TIR; TIR domain
    cl11960
    Location:46100
    Ig; Immunoglobulin domain
  3. NM_001351448.1NP_001338377.1  interleukin-1 receptor-like 2 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) encodes isoform c.
    Source sequence(s)
    AC007248, AC007271
    Conserved Domains (2) summary
    pfam01582
    Location:244394
    TIR; TIR domain
    cl11960
    Location:4699
    Ig; Immunoglobulin domain
  4. NM_001351449.2NP_001338378.1  interleukin-1 receptor-like 2 isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5), as well as variant 6, encodes isoform d.
    Source sequence(s)
    AC007248, AC007271
    Conserved Domains (2) summary
    pfam01582
    Location:235385
    TIR; TIR domain
    cl11960
    Location:1167
    Ig; Immunoglobulin domain
  5. NM_001351450.2NP_001338379.1  interleukin-1 receptor-like 2 isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6), as well as variant 5, encodes isoform d.
    Source sequence(s)
    AC007248, AC007271
    Conserved Domains (2) summary
    pfam01582
    Location:235385
    TIR; TIR domain
    cl11960
    Location:1167
    Ig; Immunoglobulin domain
  6. NM_003854.4NP_003845.2  interleukin-1 receptor-like 2 isoform a precursor

    See identical proteins and their annotated locations for NP_003845.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1), as well as variant 2, encodes the longest isoform (a).
    Source sequence(s)
    AF284434, BC107064, CA448166
    Consensus CDS
    CCDS2056.1
    UniProtKB/Swiss-Prot
    Q9HB29
    Related
    ENSP00000264257.2, ENST00000264257.7
    Conserved Domains (3) summary
    pfam01582
    Location:386536
    TIR; TIR domain
    cd05757
    Location:130218
    Ig2_IL1R_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
    cl11960
    Location:26112
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    102186973..102242910
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017005174.2XP_016860663.1  interleukin-1 receptor-like 2 isoform X3

  2. XM_011512092.1XP_011510394.1  interleukin-1 receptor-like 2 isoform X2

    Conserved Domains (4) summary
    cd05757
    Location:158246
    Ig2_IL1R_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
    smart00410
    Location:171229
    IG_like; Immunoglobulin like
    pfam01582
    Location:414564
    TIR; TIR domain
    cl11960
    Location:54140
    Ig; Immunoglobulin domain
  3. XM_011512096.1XP_011510398.1  interleukin-1 receptor-like 2 isoform X6

    Conserved Domains (4) summary
    cd05757
    Location:158246
    Ig2_IL1R_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
    smart00410
    Location:171229
    IG_like; Immunoglobulin like
    pfam01582
    Location:407510
    TIR; TIR domain
    cl11960
    Location:54140
    Ig; Immunoglobulin domain
  4. XM_011512091.1XP_011510393.1  interleukin-1 receptor-like 2 isoform X1

    Conserved Domains (4) summary
    cd05757
    Location:158245
    Ig2_IL1R_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
    smart00410
    Location:171229
    IG_like; Immunoglobulin like
    pfam01582
    Location:413563
    TIR; TIR domain
    cl11960
    Location:54140
    Ig; Immunoglobulin domain
  5. XM_011512093.1XP_011510395.1  interleukin-1 receptor-like 2 isoform X4

    Conserved Domains (4) summary
    cd05757
    Location:158244
    Ig2_IL1R_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
    smart00410
    Location:171250
    IG_like; Immunoglobulin like
    pfam01582
    Location:389539
    TIR; TIR domain
    cl11960
    Location:54140
    Ig; Immunoglobulin domain
  6. XM_017005175.1XP_016860664.1  interleukin-1 receptor-like 2 isoform X8

  7. XM_017005176.1XP_016860665.1  interleukin-1 receptor-like 2 isoform X9

  8. XM_006712820.2XP_006712883.1  interleukin-1 receptor-like 2 isoform X7

    Conserved Domains (2) summary
    pfam01582
    Location:320470
    TIR; TIR domain
    cl11960
    Location:97152
    Ig; Immunoglobulin domain
  9. XM_017005177.1XP_016860666.1  interleukin-1 receptor-like 2 isoform X11

  10. XM_011512094.1XP_011510396.1  interleukin-1 receptor-like 2 isoform X5

    See identical proteins and their annotated locations for XP_011510396.1

    Conserved Domains (4) summary
    cd05757
    Location:130218
    Ig2_IL1R_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
    smart00410
    Location:40112
    IG_like; Immunoglobulin like
    pfam01582
    Location:386536
    TIR; TIR domain
    cl11960
    Location:26112
    Ig; Immunoglobulin domain
  11. XM_017005180.1XP_016860669.1  interleukin-1 receptor-like 2 isoform X12

  12. XM_006712822.3XP_006712885.1  interleukin-1 receptor-like 2 isoform X10

    Conserved Domains (2) summary
    pfam01582
    Location:235385
    TIR; TIR domain
    cl11960
    Location:1167
    Ig; Immunoglobulin domain

RNA

  1. XR_923053.2 RNA Sequence

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