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qscR quorum-sensing control repressor [ Pseudomonas aeruginosa PAO1 ]

Gene ID: 880650, updated on 24-Aug-2024
Gene symbol
qscR
Gene description
quorum-sensing control repressor
Locus tag
PA1898
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Pseudomonas aeruginosa PAO1 (strain: PAO1)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas
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Sequence:
NC_002516.2 (2069490..2070203)

NC_002516.2Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene hypothetical protein Neighboring gene phenazine biosynthesis protein PhzA Neighboring gene phenazine biosynthesis protein PhzB

Genomic Sequence:
NC_002516.2

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. The Pseudomonas aeruginosa global regulator VqsR directly inhibits QscR to control quorum-sensing and virulence gene expression. Liang H, et al. J Bacteriol, 2012 Jun. PMID 22505688, Free PMC Article
  2. 2,5-Piperazinedione inhibits quorum sensing-dependent factor production in Pseudomonas aeruginosa PAO1. Musthafa KS, et al. J Basic Microbiol, 2012 Dec. PMID 22359266
  3. Crystal structure of QscR, a Pseudomonas aeruginosa quorum sensing signal receptor. Lintz MJ, et al. Proc Natl Acad Sci U S A, 2011 Sep 20. PMID 21911405, Free PMC Article
  4. Acyl-homoserine lactone binding to and stability of the orphan Pseudomonas aeruginosa quorum-sensing signal receptor QscR. Oinuma K, et al. J Bacteriol, 2011 Jan. PMID 21097632, Free PMC Article
  5. Activity of purified QscR, a Pseudomonas aeruginosa orphan quorum-sensing transcription factor. Lee JH, et al. Mol Microbiol, 2006 Jan. PMID 16390453

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The authors conclude that QscR acts to modulate quorum sensing through regulation of the qscR, PA1895 to PA1897 operon, apparently raising the quorum sensing threshold of the population and providing a "brake" on quorum sensing autoinduction.
    Title: The Pseudomonas aeruginosa Orphan Quorum Sensing Signal Receptor QscR Regulates Global Quorum Sensing Gene Expression by Activating a Single Linked Operon.
  2. The potential of 2,5-piperazinedione in reducing the QS-dependent phenotypic features of PAO1.
    Title: 2,5-Piperazinedione inhibits quorum sensing-dependent factor production in Pseudomonas aeruginosa PAO1.
  3. Using a qscR-lux reporter assay and Northern blot hybridization, we found that the transcription level of qscR increased 4-fold in the vqsR deletion strain compared to the wild-type PAO1 strain, indicating vqsR as a negative regulator of qscR.
    Title: The Pseudomonas aeruginosa global regulator VqsR directly inhibits QscR to control quorum-sensing and virulence gene expression.
  4. Data show that the QscR dimer appears poised to bind DNA.
    Title: Crystal structure of QscR, a Pseudomonas aeruginosa quorum sensing signal receptor.
  5. These data support a model whereby QscR polypeptides fold properly in the absence of an acyl-homoserine lactone, but soluble, acyl-homoserine lactone-free QscR does not accumulate because it is subject to rapid aggregation or proteolysis.
    Title: Acyl-homoserine lactone binding to and stability of the orphan Pseudomonas aeruginosa quorum-sensing signal receptor QscR.
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Homology

Gene Ontology Provided by PseudoCAP

Process Evidence Code Pubs
acts_upstream_of_or_within negative regulation of secondary metabolite biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within quorum sensing IDA
Inferred from Direct Assay
more info
 PubMed 
Preferred Names
quorum-sensing control repressor
NP_250589.1
  • Product name confidence: class 1 (Function experimentally demonstrated in P. aeruginosa)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_002516.2 Reference assembly

    Range
    2069490..2070203
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_250589.1 quorum-sensing control repressor [Pseudomonas aeruginosa PAO1]

    See identical proteins and their annotated locations for NP_250589.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    G3XD77, Q9RMS5
    Conserved Domains (2) summary
    smart00421
    Location:174 → 230
    HTH_LUXR; helix_turn_helix, Lux Regulon
    pfam03472
    Location:17 → 160
    Autoind_bind; Autoinducer binding domain
Nucleotide Protein
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