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gacA response regulator GacA [ Pseudomonas aeruginosa PAO1 ]

Gene ID: 880582, updated on 4-Feb-2026
Gene symbol
gacA
Gene description
response regulator GacA
Locus tag
PA2586
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Pseudomonas aeruginosa PAO1 (strain: PAO1)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas
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Sequence:
NC_002516.2 (2925788..2926432, complement)

NC_002516.2Genomic Context describing neighboring genes Neighboring gene CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase Neighboring gene excinuclease ABC subunit C Neighboring gene 2-heptyl-3-hydroxy-4(1H)-quinolone synthase Neighboring gene transcriptional regulator

Genomic Sequence:
NC_002516.2

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Two GacA-dependent small RNAs modulate the quorum-sensing response in Pseudomonas aeruginosa. Kay E, et al. J Bacteriol, 2006 Aug. PMID 16885472, Free PMC Article
  2. Pathogenicity of gacA mutant of Pseudomonas aeruginosa PA01 in the silkworm, Bombyx mori. Chieda Y, et al. FEMS Microbiol Lett, 2005 Mar 1. PMID 15727838
  3. A revised model for the role of GacS/GacA in regulating type III secretion by Pseudomonas syringae pv. tomato DC3000. O'Malley MR, et al. Mol Plant Pathol, 2020 Jan. PMID 31588661, Free PMC Article
  4. The GacS/GacA signal transduction system of Pseudomonas aeruginosa acts exclusively through its control over the transcription of the RsmY and RsmZ regulatory small RNAs. Brencic A, et al. Mol Microbiol, 2009 Aug. PMID 19602144, Free PMC Article
  5. Cross talk between type III secretion and flagellar assembly systems in Pseudomonas aeruginosa. Soscia C, et al. J Bacteriol, 2007 Apr. PMID 17307856, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A revised model for the role of GacS/GacA in regulating type III secretion by Pseudomonas syringae pv. tomato DC3000.
    Title: A revised model for the role of GacS/GacA in regulating type III secretion by Pseudomonas syringae pv. tomato DC3000.
  2. LadS HK thus forms, with the GacS/GacA TCS, a multicomponent signal transduction system with an original phosphorelay cascade, i.e. H1LadS-->D1LadS-->H2GacS-->D2GacA.
    Title: The Hybrid Histidine Kinase LadS Forms a Multicomponent Signal Transduction System with the GacS/GacA Two-Component System in Pseudomonas aeruginosa.
  3. GacA regulates rsmY and rsmZ by directly binding to sequences upstream of these genes.
    Title: The GacS/GacA signal transduction system of Pseudomonas aeruginosa acts exclusively through its control over the transcription of the RsmY and RsmZ regulatory small RNAs.
  4. A gacA mutant was less virulent to Bombyx mori larvae than the parent strain.
    Title: Pathogenicity of gacA mutant of Pseudomonas aeruginosa PA01 in the silkworm, Bombyx mori.
  5. GacS/GacA two-component system positively controls the quorum-sensing machinery and the expression of extracellular products via two small regulatory RNAs, RsmY and RsmZ
    Title: Two GacA-dependent small RNAs modulate the quorum-sensing response in Pseudomonas aeruginosa.
  6. GacA response regulator negatively affects the T3SS.
    Title: Cross talk between type III secretion and flagellar assembly systems in Pseudomonas aeruginosa.
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Homology

Gene Ontology Provided by PseudoCAP

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables transcription cis-regulatory region binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in modulation of process of another organism IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in phosphorelay signal transduction system IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of single-species biofilm formation on inanimate substrate IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
response regulator GacA
NP_251276.1
  • Product name confidence: class 1 (Function experimentally demonstrated in P. aeruginosa)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_002516.2 Reference assembly

    Range
    2925788..2926432 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_251276.1 response regulator GacA [Pseudomonas aeruginosa PAO1]

    See identical proteins and their annotated locations for NP_251276.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A3M5EXS4
    Conserved Domains (1) summary
    PRK09483
    Location:1 → 214
    PRK09483; response regulator; Provisional
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q51373.2

Gene LinkOut

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Molecular Biology Databases
Research Materials