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TRIM24 tripartite motif containing 24 [ Homo sapiens (human) ]

Gene ID: 8805, updated on 11-Sep-2019

Summary

Official Symbol
TRIM24provided by HGNC
Official Full Name
tripartite motif containing 24provided by HGNC
Primary source
HGNC:HGNC:11812
See related
Ensembl:ENSG00000122779 MIM:603406
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PTC6; TF1A; TIF1; RNF82; TIF1A; hTIF1; TIF1ALPHA
Summary
The protein encoded by this gene mediates transcriptional control by interaction with the activation function 2 (AF2) region of several nuclear receptors, including the estrogen, retinoic acid, and vitamin D3 receptors. The protein localizes to nuclear bodies and is thought to associate with chromatin and heterochromatin-associated factors. The protein is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains - a RING, a B-box type 1 and a B-box type 2 - and a coiled-coil region. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in testis (RPKM 19.9), ovary (RPKM 16.3) and 25 other tissues See more
Orthologs

Genomic context

See TRIM24 in Genome Data Viewer
Location:
7q33-q34
Exon count:
20
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (138460259..138589996)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (138145079..138270333)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene prothymosin alpha pseudogene 10 Neighboring gene inosine monophosphate dehydrogenase 1 pseudogene 3 Neighboring gene ribosomal protein S3a pseudogene 28 Neighboring gene SVOP like Neighboring gene ribosomal protein L21 pseudogene 73 Neighboring gene ribosomal protein L17 pseudogene 27

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association studies in an isolated founder population from the Pacific Island of Kosrae.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat binds to TIF1 in 293T cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Disease, organism-specific biosystem (from REACTOME)
    Disease, organism-specific biosystemBiological processes are captured in Reactome by identifying the molecules (DNA, RNA, protein, small molecules) involved in them and describing the details of their interactions. From this molecular ...
  • Diseases of signal transduction, organism-specific biosystem (from REACTOME)
    Diseases of signal transduction, organism-specific biosystemSignaling processes are central to human physiology (e.g., Pires-da Silva & Sommer 2003), and their disruption by either germ-line and somatic mutation can lead to serious disease. Here, the molecula...
  • FGFR1 mutant receptor activation, organism-specific biosystem (from REACTOME)
    FGFR1 mutant receptor activation, organism-specific biosystemThe FGFR1 gene has been shown to be subject to activating mutations, chromosomal rearrangements and gene amplification leading to a variety of proliferative and developmental disorders depending on w...
  • Oncogenic MAPK signaling, organism-specific biosystem (from REACTOME)
    Oncogenic MAPK signaling, organism-specific biosystemThe importance of the RAS/RAF/MAPK cascade in regulating cellular proliferation, differentiation and survival is highlighted by the fact that components of the pathway are mutated with high frequency...
  • Regulation of Androgen receptor activity, organism-specific biosystem (from Pathway Interaction Database)
    Regulation of Androgen receptor activity, organism-specific biosystem
    Regulation of Androgen receptor activity
  • Signaling by BRAF and RAF fusions, organism-specific biosystem (from REACTOME)
    Signaling by BRAF and RAF fusions, organism-specific biosystemIn addition to the more prevalent point mutations, BRAF and RAF1 are also subject to activation as a result of translocation events that yield truncated or fusion products (Jones et al, 2008; Cin et ...
  • Signaling by FGFR in disease, organism-specific biosystem (from REACTOME)
    Signaling by FGFR in disease, organism-specific biosystemA number of skeletal and developmental diseases have been shown to arise as a result of mutations in the FGFR1, 2 and 3 genes. These include dwarfism syndromes (achondroplasia, hypochondroplasia and...
  • Signaling by FGFR1 in disease, organism-specific biosystem (from REACTOME)
    Signaling by FGFR1 in disease, organism-specific biosystemThe FGFR1 gene has been shown to be subject to activating mutations, chromosomal rearrangements and gene amplification leading to a variety of proliferative and developmental disorders depending on w...
  • Signaling by cytosolic FGFR1 fusion mutants, organism-specific biosystem (from REACTOME)
    Signaling by cytosolic FGFR1 fusion mutants, organism-specific biosystem8p11 myeloproliferative syndrome (EMS) is an aggressive disorder that is associated with a translocation event at the FGFR1 gene on chromosome 8p11. Typical symptoms upon diagnosis include eosinophi...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
estrogen response element binding IDA
Inferred from Direct Assay
more info
PubMed 
lysine-acetylated histone binding IDA
Inferred from Direct Assay
more info
PubMed 
NOT methylated histone binding IDA
Inferred from Direct Assay
more info
PubMed 
nuclear receptor binding IEA
Inferred from Electronic Annotation
more info
 
p53 binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
signaling receptor binding TAS
Traceable Author Statement
more info
PubMed 
transcription coactivator activity IDA
Inferred from Direct Assay
more info
PubMed 
ubiquitin protein ligase activity IEA
Inferred from Electronic Annotation
more info
 
ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
zinc ion binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
calcium ion homeostasis IEA
Inferred from Electronic Annotation
more info
 
cellular response to estrogen stimulus IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cell proliferation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
protein autophosphorylation IEA
Inferred from Electronic Annotation
more info
 
protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of protein stability IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of signal transduction by p53 class mediator IEA
Inferred from Electronic Annotation
more info
 
regulation of vitamin D receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
transcription by RNA polymerase II TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
nuclear euchromatin IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
perichromatin fibrils IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
transcription intermediary factor 1-alpha
Names
E3 ubiquitin-protein ligase TRIM24
RING finger protein 82
RING-type E3 ubiquitin transferase TIF1-alpha
TIF1-alpha
transcriptional intermediary factor 1
NP_003843.3
NP_056989.2
XP_024302749.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_023286.1 RefSeqGene

    Range
    5001..130255
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_003852.4NP_003843.3  transcription intermediary factor 1-alpha isoform b

    See identical proteins and their annotated locations for NP_003843.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AC008265, AC013429, AF119042, AK075306, BC028689, CB988362
    Consensus CDS
    CCDS47720.1
    UniProtKB/Swiss-Prot
    O15164
    UniProtKB/TrEMBL
    A0A024R784
    Related
    ENSP00000390829.2, ENST00000415680.6
    Conserved Domains (6) summary
    cd05502
    Location:866973
    Bromo_tif1_like; Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or ...
    smart00502
    Location:266392
    BBC; B-Box C-terminal domain
    smart00336
    Location:158194
    BBOX; B-Box-type zinc finger
    cd00021
    Location:221259
    BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
    cd15622
    Location:794836
    PHD_TIF1alpha; PHD finger found in transcription intermediary factor 1-alpha (TIF1-alpha)
    cd16764
    Location:53134
    RING-HC_TIF1alpha; RING finger, HC subclass, found in transcription inknown asiary factor 1-alpha (TIF1-alpha)
  2. NM_015905.3NP_056989.2  transcription intermediary factor 1-alpha isoform a

    See identical proteins and their annotated locations for NP_056989.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AA844662, AC008265, AC013429, AK075306, BC028689, CB988362
    Consensus CDS
    CCDS5847.1
    UniProtKB/Swiss-Prot
    O15164
    Related
    ENSP00000340507.4, ENST00000343526.9
    Conserved Domains (7) summary
    cd05502
    Location:9001007
    Bromo_tif1_like; Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or ...
    smart00502
    Location:266392
    BBC; B-Box C-terminal domain
    smart00336
    Location:158194
    BBOX; B-Box-type zinc finger
    cd00021
    Location:221259
    BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
    cd15622
    Location:828870
    PHD_TIF1alpha; PHD finger found in transcription intermediary factor 1-alpha (TIF1-alpha)
    cd16764
    Location:53134
    RING-HC_TIF1alpha; RING finger, HC subclass, found in transcription inknown asiary factor 1-alpha (TIF1-alpha)
    cl25764
    Location:430564
    PAT1; Topoisomerase II-associated protein PAT1

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    138460259..138589996
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024446981.1XP_024302749.1  transcription intermediary factor 1-alpha isoform X1

    Conserved Domains (7) summary
    cd05502
    Location:881988
    Bromo_tif1_like; Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or ...
    smart00502
    Location:247373
    BBC; B-Box C-terminal domain
    smart00336
    Location:139175
    BBOX; B-Box-type zinc finger
    cd00021
    Location:202240
    BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
    cd15622
    Location:809851
    PHD_TIF1alpha; PHD finger found in transcription intermediary factor 1-alpha (TIF1-alpha)
    cl17238
    Location:60115
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
    cl25764
    Location:416545
    PAT1; Topoisomerase II-associated protein PAT1
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