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lasB elastase LasB [ Pseudomonas aeruginosa PAO1 ]

Gene ID: 880368, updated on 6-Jul-2026
Gene symbol
lasB
Gene description
elastase LasB
Locus tag
PA3724
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Pseudomonas aeruginosa PAO1 (strain: PAO1)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas
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Sequence:
NC_002516.2 (4168987..4170483, complement)

NC_002516.2Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene FMN oxidoreductase Neighboring gene single-stranded-DNA-specific exonuclease RecJ Neighboring gene hypothetical protein

Genomic Sequence:
NC_002516.2

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Pseudomonas aeruginosa Elastase Contributes to the Establishment of Chronic Lung Colonization and Modulates the Immune Response in a Murine Model. Cigana C, et al. Front Microbiol, 2020. PMID 33510733, Free PMC Article
  2. The thermolysin-like metalloproteinase and virulence factor LasB from pathogenic Pseudomonas aeruginosa induces anoikis of human vascular cells. Beaufort N, et al. Cell Microbiol, 2011 Aug. PMID 21501369
  3. Role of α-helical structure in organic solvent-activated homodimer of elastase strain K. Rahman RN, et al. Int J Mol Sci, 2011. PMID 22016627, Free PMC Article
  4. Relationship Among Antibiotic Resistance, Biofilm Formation and lasB Gene in Pseudomonas Aeruginosa Isolated from Burn Patients. Roshani-Asl P, et al. Clin Lab, 2018 Sep 1. PMID 30274028
  5. A comprehensive alanine-scanning mutagenesis study reveals roles for salt bridges in the structure and activity of Pseudomonas aeruginosa elastase. Bian F, et al. PLoS One, 2015. PMID 25815820, Free PMC Article

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Molecular Analysis of the Contribution of Alkaline Protease A and Elastase B to the Virulence of Pseudomonas aeruginosa Bloodstream Infections.
    Title: Molecular Analysis of the Contribution of Alkaline Protease A and Elastase B to the Virulence of Pseudomonas aeruginosa Bloodstream Infections.
  2. LasB, PIV, and LasA are activated postsecretionally in a cascading manner in which the initial activation of LasB was controlled tightly by quorum sensing (QS) at the protein level in addition to the well-known transcriptional control of these proteases by QS
    Title: Quorum sensing-dependent post-secretional activation of extracellular proteases in Pseudomonas aeruginosa.
  3. In order to check the presence of other chemical groups on modified lysines identified on LasB and CbpD, we used 1- and 2- dimensional gel electrophoresis approaches to target lysine modified by 7 other modifications: butyrylation, crotonylation, dimethylation, malonylation, methylation, propionylation, and trimethylation.
    Title: LasB and CbpD Virulence Factors of Pseudomonas aeruginosa Carry Multiple Post-Translational Modifications on Their Lysine Residues.
  4. There is no relationship among elastase gene (lasB) presence, antibiotic resistance, and biofilm formation in P. aeruginosa strains isolated from burn patients.
    Title: Relationship Among Antibiotic Resistance, Biofilm Formation and lasB Gene in Pseudomonas Aeruginosa Isolated from Burn Patients.
  5. Using a model Proteobacterium, P. aeruginosa, which expresses the gluten-degrading protease elastase (LasB), and its isogenic non-functional lasB mutant19, study in mouse Celiac disease model shows an elastase-dependent inflammatory response mediated by the protease-activated receptor-2 (PAR-2) pathway.
    Title: Duodenal bacterial proteolytic activity determines sensitivity to dietary antigen through protease-activated receptor-2.
  6. This study represents a systematic mutational analyses of salt bridges in the model metalloprotease PAE and provides important insights into the structure-function relationship of enzymes
    Title: A comprehensive alanine-scanning mutagenesis study reveals roles for salt bridges in the structure and activity of Pseudomonas aeruginosa elastase.
  7. both bactericidal and cell-recruiting activities of MIG/CXCL9 are corrupted by P. aeruginosa through release of elastase, and this may contribute to impaired airway host defense in CF.
    Title: Expression of MIG/CXCL9 in cystic fibrosis and modulation of its activities by elastase of Pseudomonas aeruginosa.
  8. Data indicate that the purified elastase protein had exhibited a homodimer size of 65 kDa by SDS-PAGE and MALDI-TOF, a size which is totally distinct from that of typically reported 33 kDa monomer.
    Title: Role of α-helical structure in organic solvent-activated homodimer of elastase strain K.
  9. the protease LasB, directly affected VE-cadherin proteolysis
    Title: VE-cadherin cleavage by LasB protease from Pseudomonas aeruginosa facilitates type III secretion system toxicity in endothelial cells.
  10. P. aeruginosa elastase transiently disrupts tight junctions in human nasal epithelial cells and downregulates PAR-2.
    Title: Pseudomonas aeruginosa elastase causes transient disruption of tight junctions and downregulation of PAR-2 in human nasal epithelial cells.
Submit: New GeneRIF Correction See all GeneRIFs (15)

Homology

Gene Ontology Provided by PseudoCAP

Function Evidence Code Pubs
enables endopeptidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables metalloendopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in bacterial-type flagellum-dependent swarming motility IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein secretion by the type II secretion system IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein transport by the Sec complex IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in single-species biofilm formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region EXP
Inferred from Experiment
more info
 PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
elastase LasB
NP_252413.1
  • Product name confidence: class 1 (Function experimentally demonstrated in P. aeruginosa)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_002516.2 Reference assembly

    Range
    4168987..4170483 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_252413.1 elastase LasB [Pseudomonas aeruginosa PAO1]

    See identical proteins and their annotated locations for NP_252413.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    I6R951
    Conserved Domains (1) summary
    COG3227
    Location:1 → 492
    LasB; Zn-dependent metalloprotease [Posttranslational modification, protein turnover, chaperones]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P14756.1

Gene LinkOut

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Molecular Biology Databases
Research Materials