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SUCLG2 succinate-CoA ligase GDP-forming subunit beta [ Homo sapiens (human) ]

Gene ID: 8801, updated on 7-Jun-2020

Summary

Official Symbol
SUCLG2provided by HGNC
Official Full Name
succinate-CoA ligase GDP-forming subunit betaprovided by HGNC
Primary source
HGNC:HGNC:11450
See related
Ensembl:ENSG00000172340 MIM:603922
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
G-SCS; GBETA; GTPSCS
Summary
This gene encodes a GTP-specific beta subunit of succinyl-CoA synthetase. Succinyl-CoA synthetase catalyzes the reversible reaction involving the formation of succinyl-CoA and succinate. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 5 and 12. [provided by RefSeq, Apr 2010]
Expression
Ubiquitous expression in colon (RPKM 21.2), kidney (RPKM 16.3) and 25 other tissues See more
Orthologs

Genomic context

See SUCLG2 in Genome Data Viewer
Location:
3p14.1
Exon count:
14
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (67360460..67654614, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (67410884..67705038, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC112267879 Neighboring gene microRNA 4272 Neighboring gene NADH:ubiquinone oxidoreductase subunit B4 pseudogene 1 Neighboring gene uncharacterized LOC105377148 Neighboring gene SUCLG2 antisense RNA 1 (head to head) Neighboring gene FAM19A1 intron homotypic cluster of transcription factor binding sites enhancer Neighboring gene TAFA chemokine like family member 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A meta-analysis of genome-wide association studies for serum total IgE in diverse study populations.
NHGRI GWA Catalog
An atlas of genetic influences on human blood metabolites.
NHGRI GWA Catalog
Genome-wide meta-analysis of five Asian cohorts identifies PDGFRA as a susceptibility locus for corneal astigmatism.
NHGRI GWA Catalog
Hundreds of variants clustered in genomic loci and biological pathways affect human height.
NHGRI GWA Catalog
SUCLG2 identified as both a determinator of CSF Aß1-42-levels and an attenuator of cognitive decline in Alzheimer's disease.
NHGRI GWA Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of succinate-CoA ligase, GDP-forming, beta subunit (SUCLG2) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Pol gag-pol HIV-1 Pol is identified to have a physical interaction with succinate-CoA ligase, GDP-forming, beta subunit (SUCLG2) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
integrase gag-pol HIV-1 IN is identified to have a physical interaction with succinate-CoA ligase, GDP-forming, beta subunit (SUCLG2) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
GDP binding IEA
Inferred from Electronic Annotation
more info
 
GTP binding IEA
Inferred from Electronic Annotation
more info
 
magnesium ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein-containing complex binding IEA
Inferred from Electronic Annotation
more info
 
succinate-CoA ligase (ADP-forming) activity IEA
Inferred from Electronic Annotation
more info
 
succinate-CoA ligase (GDP-forming) activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
succinate-CoA ligase (GDP-forming) activity NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
succinate metabolic process IEA
Inferred from Electronic Annotation
more info
 
succinyl-CoA metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
succinyl-CoA metabolic process NAS
Non-traceable Author Statement
more info
PubMed 
tricarboxylic acid cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
tricarboxylic acid cycle IEA
Inferred from Electronic Annotation
more info
 
tricarboxylic acid cycle TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
mitochondrial matrix TAS
Traceable Author Statement
more info
 
mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
 
succinate-CoA ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
succinate-CoA ligase complex (GDP-forming) IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial
Names
GTP-specific succinyl-CoA synthetase beta subunit
GTP-specific succinyl-CoA synthetase subunit beta
SCS-betaG
succinate-CoA ligase GDP-forming beta subunit
succinyl-CoA ligase [GDP-forming] subunit beta, mitochondrial
succinyl-CoA ligase, GDP-forming, beta chain, mitochondrial
succinyl-CoA synthetase, beta-G chain
NP_001171070.1
NP_003839.2
XP_016862909.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_052945.1 RefSeqGene

    Range
    5001..284898
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001177599.1NP_001171070.1  succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial isoform 1 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC112213, AK310527, BC068602
    Consensus CDS
    CCDS54605.1
    UniProtKB/Swiss-Prot
    Q96I99
    Related
    ENSP00000419325.1, ENST00000493112.5
    Conserved Domains (3) summary
    PRK00696
    Location:39396
    sucC; succinyl-CoA synthetase subunit beta; Provisional
    pfam00549
    Location:306396
    Ligase_CoA; CoA-ligase
    pfam08442
    Location:39247
    ATP-grasp_2; ATP-grasp domain
  2. NM_003848.4NP_003839.2  succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial isoform 2 precursor

    See identical proteins and their annotated locations for NP_003839.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR, and 3' coding region, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AF131748, BC007716, BC068602
    Consensus CDS
    CCDS43104.1
    UniProtKB/Swiss-Prot
    Q96I99
    UniProtKB/TrEMBL
    A0A024R325
    Related
    ENSP00000307432.5, ENST00000307227.9
    Conserved Domains (3) summary
    PRK00696
    Location:39420
    sucC; succinyl-CoA synthetase subunit beta; Provisional
    pfam00549
    Location:306420
    Ligase_CoA; CoA-ligase
    pfam08442
    Location:39247
    ATP-grasp_2; ATP-grasp domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    67360460..67654614 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017007420.2XP_016862909.1  succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial isoform X1

    Related
    ENSP00000417589.1, ENST00000492795.1

RNA

  1. XR_001740348.2 RNA Sequence

  2. XR_001740350.2 RNA Sequence

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