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iscR HTH-type transcriptional regulator [ Pseudomonas aeruginosa PAO1 ]

Gene ID: 879919, updated on 6-Jul-2026
Gene symbol
iscR
Gene description
HTH-type transcriptional regulator
Locus tag
PA3815
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Pseudomonas aeruginosa PAO1 (strain: PAO1)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas
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Sequence:
NC_002516.2 (4272165..4272656, complement)

NC_002516.2Genomic Context describing neighboring genes Neighboring gene scaffold protein Neighboring gene cysteine desulfurase Neighboring gene O-acetylserine synthase Neighboring gene methyltransferase

Genomic Sequence:
NC_002516.2

Go to nucleotide: Graphics FASTA GenBank

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. P. aeruginosa IscR as it contributes to the roles of an [Fe-S] cluster in several biologically important cellular activities.[IscR]
    Title: Transcriptional regulation of the Pseudomonas aeruginosa iron-sulfur cluster assembly pathway by binding of IscR to multiple sites.
  2. IscR is a transcriptional regulator of the isc operon and contributes to iron homeostasis and resistance to oxidants in Pseudomonas aeruginosa.
    Title: The iron-sulphur cluster biosynthesis regulator IscR contributes to iron homeostasis and resistance to oxidants in Pseudomonas aeruginosa.
  3. Altogether, Pseudomonas aeruginosa tpx is a novel member of the IscR regulon and plays a primary role in protecting the bacteria from submillimolar concentrations of H(2)O(2).
    Title: Pseudomonas aeruginosa thiol peroxidase protects against hydrogen peroxide toxicity and displays atypical patterns of gene regulation.
Submit: New GeneRIF Correction

Homology

Gene Ontology Provided by PseudoCAP

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables double-stranded DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of DNA-templated transcription EXP
Inferred from Experiment
more info
 PubMed 
involved_in negative regulation of DNA-templated transcription IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
Preferred Names
HTH-type transcriptional regulator
NP_252504.1
  • Product name confidence: class 1: Function experimentally demonstrated in P. aeruginosa

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_002516.2 Reference assembly

    Range
    4272165..4272656 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_252504.1 HTH-type transcriptional regulator [Pseudomonas aeruginosa PAO1]

    See identical proteins and their annotated locations for NP_252504.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    Q9HXI7
    Conserved Domains (1) summary
    TIGR02010
    Location:1 → 135
    IscR; iron-sulfur cluster assembly transcription factor IscR
Nucleotide Protein
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