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psrA transcriptional regulator PsrA [ Pseudomonas aeruginosa PAO1 ]

Gene ID: 879874, updated on 24-Aug-2024
Gene symbol
psrA
Gene description
transcriptional regulator PsrA
Locus tag
PA3006
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Pseudomonas aeruginosa PAO1 (strain: PAO1)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas
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Sequence:
NC_002516.2 (3366970..3367671, complement)

NC_002516.2Genomic Context describing neighboring genes Neighboring gene S-methyl-5'-thioinosine phosphorylase Neighboring gene beta-hexosaminidase Neighboring gene LexA repressor Neighboring gene cell division inhibitor SulA

Genomic Sequence:
NC_002516.2

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. PsrA is a positive transcriptional regulator of the type III secretion system in Pseudomonas aeruginosa. Shen DK, et al. Infect Immun, 2006 Feb. PMID 16428760, Free PMC Article
  2. Regulation of rpoS gene expression in Pseudomonas: involvement of a TetR family regulator. Kojic M, et al. J Bacteriol, 2001 Jun. PMID 11371535, Free PMC Article
  3. The long-chain fatty acid sensor, PsrA, modulates the expression of rpoS and the type III secretion exsCEBA operon in Pseudomonas aeruginosa. Kang Y, et al. Mol Microbiol, 2009 Jul. PMID 19508282, Free PMC Article
  4. Induction by cationic antimicrobial peptides and involvement in intrinsic polymyxin and antimicrobial peptide resistance, biofilm formation, and swarming motility of PsrA in Pseudomonas aeruginosa. Gooderham WJ, et al. J Bacteriol, 2008 Aug. PMID 18556795, Free PMC Article
  5. The Pseudomonas aeruginosa PsrA responds to long-chain fatty acid signals to regulate the fadBA5 beta-oxidation operon. Kang Y, et al. Microbiology (Reading), 2008 Jun. PMID 18524913

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Long-chain fatty acids influence PsrA regulation to control fatty acid metabolism and the expression of rpoS and the exsCEBA operon.
    Title: The long-chain fatty acid sensor, PsrA, modulates the expression of rpoS and the type III secretion exsCEBA operon in Pseudomonas aeruginosa.
  2. This suggests that PsrA might be a key regulator of antimicrobial peptide resistance and virulence.
    Title: Induction by cationic antimicrobial peptides and involvement in intrinsic polymyxin and antimicrobial peptide resistance, biofilm formation, and swarming motility of PsrA in Pseudomonas aeruginosa.
  3. PsrA is a fadBA5 regulator that binds and responds to LCFA signals in P. aeruginosa
    Title: The Pseudomonas aeruginosa PsrA responds to long-chain fatty acid signals to regulate the fadBA5 beta-oxidation operon.
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Homology

Gene Ontology Provided by PseudoCAP

Process Evidence Code Pubs
acts_upstream_of_or_within positive regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of protein secretion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of DNA-templated transcription IGI
Inferred from Genetic Interaction
more info
 PubMed 
Preferred Names
transcriptional regulator PsrA
NP_251696.1
  • Product name confidence: class 1 (Function experimentally demonstrated in P. aeruginosa)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_002516.2 Reference assembly

    Range
    3366970..3367671 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_251696.1 transcriptional regulator PsrA [Pseudomonas aeruginosa PAO1]

    See identical proteins and their annotated locations for NP_251696.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    Q9HZJ9
    Conserved Domains (2) summary
    pfam17939
    Location:93 → 206
    TetR_C_30; Tetracyclin repressor-like, C-terminal domain
    NF037937
    Location:8 → 95
    septum_RefZ; forespore capture DNA-binding protein RefZ
Nucleotide Protein
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