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exsA exoenzyme S transcriptional regulator ExsA [ Pseudomonas aeruginosa PAO1 ]

Gene ID: 879712, updated on 30-Jul-2025
Gene symbol
exsA
Gene description
exoenzyme S transcriptional regulator ExsA
Locus tag
PA1713
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Pseudomonas aeruginosa PAO1 (strain: PAO1)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas
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Sequence:
NC_002516.2 (1857273..1858109)

NC_002516.2Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene exoenzyme S synthesis protein ExsB Neighboring gene hypothetical protein Neighboring gene type III export apparatus protein Neighboring gene type III secretion outer membrane protein PscC

Genomic Sequence:
NC_002516.2

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. The small RNA PrrH aggravates Pseudomonas aeruginosa-induced acute lung injury by regulating the type III secretion system activator ExsA. Shi Q, et al. Microbiol Spectr, 2024 Mar 5. PMID 38289930, Free PMC Article
  2. Structural Analysis of the Regulatory Domain of ExsA, a Key Transcriptional Regulator of the Type Three Secretion System in Pseudomonas aeruginosa. Shrestha M, et al. PLoS One, 2015. PMID 26317977, Free PMC Article
  3. ExsA and LcrF recognize similar consensus binding sites, but differences in their oligomeric state influence interactions with promoter DNA. King JM, et al. J Bacteriol, 2013 Dec. PMID 24142246, Free PMC Article
  4. Cloning and sequence analysis of a trans-regulatory locus required for exoenzyme S synthesis in Pseudomonas aeruginosa. Frank DW, et al. J Bacteriol, 1991 Oct. PMID 1655713, Free PMC Article
  5. The distal ExsA-binding site in Pseudomonas aeruginosa type III secretion system promoters is the primary determinant for promoter-specific properties. Brutinel ED, et al. J Bacteriol, 2012 May. PMID 22408165, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The small RNA PrrH aggravates Pseudomonas aeruginosa-induced acute lung injury by regulating the type III secretion system activator ExsA.
    Title: The small RNA PrrH aggravates Pseudomonas aeruginosa-induced acute lung injury by regulating the type III secretion system activator ExsA.
  2. study reports that Vfr directly controls exsA transcription, the master regulator of T3SS gene expression, from a newly identified promoter located immediately upstream of exsA
    Title: Vfr Directly Activates exsA Transcription To Regulate Expression of the Pseudomonas aeruginosa Type III Secretion System.
  3. The crystal structure suggests two models for the ExsA dimer. Both models confirmed the previously shown involvement of helix alpha-3 in ExsA dimerization but one also suggest a role for helix alpha-2.
    Title: Structural Analysis of the Regulatory Domain of ExsA, a Key Transcriptional Regulator of the Type Three Secretion System in Pseudomonas aeruginosa.
  4. ExsD trimerization prevents ExsD from inhibiting ExsA-dependent transcription.
    Title: Self-trimerization of ExsD limits inhibition of the Pseudomonas aeruginosa transcriptional activator ExsA in vitro.
  5. The combined data support a model in which two ExsA(His) molecules bind adjacent sites on the promoter to activate type III secretion system gene transcription.
    Title: Characterization of ExsA and of ExsA-dependent promoters required for expression of the Pseudomonas aeruginosa type III secretion system.
  6. characterized the self-association states of ExsC, ExsD, and ExsE and the binding interactions of ExsC with ExsE and ExsD
    Title: Biochemical characterization of a regulatory cascade controlling transcription of the Pseudomonas aeruginosa type III secretion system.
Submit: New GeneRIF Correction

Homology

Gene Ontology Provided by PseudoCAP

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription activator activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific DNA binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables sequence-specific DNA binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription cis-regulatory region binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of protein secretion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of DNA-templated transcription initiation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of primary metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of protein-DNA complex IMP
Inferred from Mutant Phenotype
more info
 PubMed 
part_of protein-DNA complex IPI
Inferred from Physical Interaction
more info
 PubMed 
Preferred Names
exoenzyme S transcriptional regulator ExsA
NP_250404.1
  • Product name confidence: class 1 (Function experimentally demonstrated in P. aeruginosa)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_002516.2 Reference assembly

    Range
    1857273..1858109
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_250404.1 exoenzyme S transcriptional regulator ExsA [Pseudomonas aeruginosa PAO1]

    See identical proteins and their annotated locations for NP_250404.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A0D6I0W8
    Conserved Domains (1) summary
    COG2207
    Location:149 → 268
    AraC; AraC-type DNA-binding domain and AraC-containing proteins [Transcription]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P26993.2

Gene LinkOut

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Molecular Biology Databases
Research Materials