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mucA sigma factor AlgU negative regulator MucA [ Pseudomonas aeruginosa PAO1 ]

Gene ID: 879357, updated on 19-Nov-2025
Gene symbol
mucA
Gene description
sigma factor AlgU negative regulator MucA
Locus tag
PA0763
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Pseudomonas aeruginosa PAO1 (strain: PAO1)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas
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Sequence:
NC_002516.2 (831914..832498)

NC_002516.2Genomic Context describing neighboring genes Neighboring gene L-aspartate oxidase Neighboring gene RNA polymerase sigma factor AlgU Neighboring gene sigma factor AlgU regulator MucB Neighboring gene positive regulator for alginate biosynthesis MucC Neighboring gene serine protease MucD

Genomic Sequence:
NC_002516.2

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. The anti-sigma factor MucA is required for viability in Pseudomonas aeruginosa. Schofield MC, et al. Mol Microbiol, 2021 Aug. PMID 33905139, Free PMC Article
  2. [MucA mutation and its alginate-production in clinically isolated Pseudomonas aeruginosa]. Meng J, et al. Zhong Nan Da Xue Xue Bao Yi Xue Ban, 2009 Dec. PMID 20045914
  3. Metabolic profiling of Pseudomonas aeruginosa demonstrates that the anti-sigma factor MucA modulates osmotic stress tolerance. Behrends V, et al. Mol Biosyst, 2010 Mar. PMID 20174684
  4. Vanadate and triclosan synergistically induce alginate production by Pseudomonas aeruginosa strain PAO1. Damron FH, et al. Mol Microbiol, 2011 Jul. PMID 21631603, Free PMC Article
  5. Risk factors for mortality in patients with Pseudomonas aeruginosa pneumonia: Clinical impact of mucA gene mutation. Jung IY, et al. Respir Med, 2018 Jul. PMID 29957276

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The anti-sigma factor MucA is required for viability in Pseudomonas aeruginosa.
    Title: The anti-sigma factor MucA is required for viability in Pseudomonas aeruginosa.
  2. Molecular basis of the lipid-induced MucA-MucB dissociation in Pseudomonas aeruginosa.
    Title: Molecular basis of the lipid-induced MucA-MucB dissociation in Pseudomonas aeruginosa.
  3. The structures reveal the molecular basis for MucA recognition by MucB in the periplasm and AlgU in the cytoplasm, thus providing an important step in understanding the mechanisms that regulate a key signal transduction pathway involved in P. aeruginosa pathogenesis.
    Title: Structural basis for the recognition of MucA by MucB and AlgU in Pseudomonas aeruginosa.
  4. mucA gene mutation influenced the virulence of Pseudomonas aeruginosa in P. aeruginosa pneumonia in COPD patients.
    Title: Risk factors for mortality in patients with Pseudomonas aeruginosa pneumonia: Clinical impact of mucA gene mutation.
  5. AlgU controls rsmA transcription and is responsible for RsmA activity in mucA mutant strains.
    Title: Pseudomonas aeruginosa AlgU Contributes to Posttranscriptional Activity by Increasing rsmA Expression in a mucA22 Strain.
  6. Inactivation of mucA (the gene responsible for the mucoid phenotype) in PAO1 leads to p38alpha MAPK activation by both TLR2 and TLR5, as observed in the cystic fibrosis clinical mucoid isolate PACF508.
    Title: Mucoid Pseudomonas aeruginosa caused by mucA mutations result in activation of TLR2 in addition to TLR5 in airway epithelial cells.
  7. Alginate biosynthesis in Pseudomonas aeruginosa is a highly regulated by algU and mucA genes.
    Title: Different mutations in mucA gene of Pseudomonas aeruginosa mucoid strains in cystic fibrosis patients and their effect on algU gene expression.
  8. Alginate induction in PAO1 on Pseudomonas isolation agar with ammonium metavanadate was correlated with increased proteolytic degradation of MucA.
    Title: Vanadate and triclosan synergistically induce alginate production by Pseudomonas aeruginosa strain PAO1.
  9. Genotypic variants of the P. aeruginosa dominant strains can coexist in the chronic colonization in CF patients. These variants can be undetected by RFLP and they might present variable antibiotic susceptibility.
    Title: [Polymorphism of mucA and fpvA genes in Pseudomonas aeruginosa isolates from cystic fibrosis patients: co-existence of genetically different variants].
  10. MucA mutation correlates with the alginate production and phenotype of bacterial colonies.
    Title: [MucA mutation and its alginate-production in clinically isolated Pseudomonas aeruginosa].
Submit: New GeneRIF Correction See all GeneRIFs (13)

Homology

Gene Ontology Provided by PseudoCAP

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sigma factor antagonist activity IEA
Inferred from Electronic Annotation
more info
  
enables sigma factor antagonist activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in alginic acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of polysaccharide biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
sigma factor AlgU negative regulator MucA
NP_249454.1
  • Product name confidence: class 1 (Function experimentally demonstrated in P. aeruginosa)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_002516.2 Reference assembly

    Range
    831914..832498
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_249454.1 sigma factor AlgU negative regulator MucA [Pseudomonas aeruginosa PAO1]

    See identical proteins and their annotated locations for NP_249454.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P38107
    Conserved Domains (1) summary
    COG3073
    Location:1 → 194
    RseA; Negative regulator of sigma E activity [Signal transduction mechanisms]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38107.1

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