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plcH hemolytic phospholipase C [ Pseudomonas aeruginosa PAO1 ]

Gene ID: 879296, updated on 11-Sep-2024

Summary

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Gene symbol
plcH
Gene description
hemolytic phospholipase C
Locus tag
PA0844
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Pseudomonas aeruginosa PAO1 (strain: PAO1)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas
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Genomic context

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Sequence:
NC_002516.2 (919258..921450, complement)

NC_002516.2Genomic Context describing neighboring genes Neighboring gene glycosyl transferase family protein Neighboring gene phospholipase C accessory protein PlcR Neighboring gene neutral ceramidase Neighboring gene sulfate transporter CysZ

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_002516.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Long-distance delivery of bacterial virulence factors by Pseudomonas aeruginosa outer membrane vesicles. Bomberger JM, et al. PLoS Pathog, 2009 Apr. PMID 19360133, Free PMC Article
  2. PlcR1 and PlcR2 are putative calcium-binding proteins required for secretion of the hemolytic phospholipase C of Pseudomonas aeruginosa. Cota-Gomez A, et al. Infect Immun, 1997 Jul. PMID 9199466, Free PMC Article
  3. Purification, characterization, and identification of a sphingomyelin synthase from Pseudomonas aeruginosa. PlcH is a multifunctional enzyme. Luberto C, et al. J Biol Chem, 2003 Aug 29. PMID 12799377
  4. Role of the Pseudomonas aeruginosa PlcH Tat signal peptide in protein secretion, transcription, and cross-species Tat secretion system compatibility. Snyder A, et al. J Bacteriol, 2006 Mar. PMID 16484187, Free PMC Article
  5. Anr and its activation by PlcH activity in Pseudomonas aeruginosa host colonization and virulence. Jackson AA, et al. J Bacteriol, 2013 Jul. PMID 23667230, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Authors demonstrated the presence of a negative feedback loop in which Anr repressed plcH transcription in cells grown at low oxygen.
    Title: Global regulator Anr represses PlcH phospholipase activity in Pseudomonas aeruginosa when oxygen is limiting.
  2. The data suggest that PlcH activity promotes Anr activity in oxic environments and that Anr activity contributes to virulence.
    Title: Anr and its activation by PlcH activity in Pseudomonas aeruginosa host colonization and virulence.
  3. GbdR is the primary regulator of plcH and pchP expression in phsophatidylcholine-rich environments, such as the lung
    Title: GbdR regulates Pseudomonas aeruginosa plcH and pchP transcription in response to choline catabolites.
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General gene information

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Homology

Gene Ontology Provided by PseudoCAP

Function Evidence Code Pubs
enables lipase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphatidylcholine phospholipase C activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables sphingomyelin synthase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within hemolysis in another organism IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within hemolysis in another organism IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within protein secretion by the type II secretion system IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular space IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
hemolytic phospholipase C
NP_249535.1
  • Product name confidence: class 1 (Function experimentally demonstrated in P. aeruginosa)

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_002516.2 Reference assembly

    Range
    919258..921450 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_249535.1 hemolytic phospholipase C [Pseudomonas aeruginosa PAO1]

    See identical proteins and their annotated locations for NP_249535.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A367M8L9
    Conserved Domains (1) summary
    TIGR03396
    Location:9 → 726
    PC_PLC; phospholipase C, phosphocholine-specific, Pseudomonas-type
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P06200.2

Gene LinkOut

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Molecular Biology Databases