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phoQ two-component sensor PhoQ [ Pseudomonas aeruginosa PAO1 ]

Gene ID: 879187, updated on 30-Jul-2025
Gene symbol
phoQ
Gene description
two-component sensor PhoQ
Locus tag
PA1180
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Pseudomonas aeruginosa PAO1 (strain: PAO1)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas
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Sequence:
NC_002516.2 (1278362..1279708)

NC_002516.2Genomic Context describing neighboring genes Neighboring gene nitrate reductase protein NapE Neighboring gene PhoP/Q and low Mg2+ inducible outer membrane protein H1 Neighboring gene two-component response regulator PhoP Neighboring gene sensor protein Neighboring gene transcriptional regulator

Genomic Sequence:
NC_002516.2

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Sensing Mg(2+) contributes to the resistance of Pseudomonas aeruginosa to complement-mediated opsonophagocytosis. Qadi M, et al. Environ Microbiol, 2017 Oct. PMID 28805355
  2. The sensor kinase PhoQ mediates virulence in Pseudomonas aeruginosa. Gooderham WJ, et al. Microbiology (Reading), 2009 Mar. PMID 19246741
  3. Magnesium limitation is an environmental trigger of the Pseudomonas aeruginosa biofilm lifestyle. Mulcahy H, et al. PLoS One, 2011. PMID 21858064, Free PMC Article
  4. The Pseudomonas aeruginosa PhoP-PhoQ two-component regulatory system is induced upon interaction with epithelial cells and controls cytotoxicity and inflammation. Gellatly SL, et al. Infect Immun, 2012 Sep. PMID 22710876, Free PMC Article
  5. Contribution of the PhoP-PhoQ and PmrA-PmrB two-component regulatory systems to Mg2+-induced gene regulation in Pseudomonas aeruginosa. McPhee JB, et al. J Bacteriol, 2006 Jun. PMID 16707691, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. expression of PhoQ is essential to detect Mg(2+) and reduce the expression of OprH, a previously unrecognized C3 binding molecule that promotes the opsonophagocytosis of P. aeruginosa.
    Title: Sensing Mg(2+) contributes to the resistance of Pseudomonas aeruginosa to complement-mediated opsonophagocytosis.
  2. The interaction of wild-type (WT) bacteria that had adhered to epithelial cells led to a large upregulation of the expression of the oprH-phoP-phoQ operon, in a PhoQ-dependent manner
    Title: The Pseudomonas aeruginosa PhoP-PhoQ two-component regulatory system is induced upon interaction with epithelial cells and controls cytotoxicity and inflammation.
  3. Data suggest that PhoPQ controls the equilibrium of the small regulatory RNAs and thus fine-tunes the expression of genes in the RetS pathway.
    Title: Magnesium limitation is an environmental trigger of the Pseudomonas aeruginosa biofilm lifestyle.
  4. Results suggest that polymyxin B resistance among clinical isolates of P. aeruginosa is associated with alterations in two-component regulatory systems of phoPQ or pmrAB.
    Title: Alterations in two-component regulatory systems of phoPQ and pmrAB are associated with polymyxin B resistance in clinical isolates of Pseudomonas aeruginosa.
  5. phoQ mutants showed reduced virulence in lettuce leaves, reduced cytotoxicity toward cultured human lung epithelial cells, and are highly attenuated for virulence in a model of chronic lung infection.
    Title: The sensor kinase PhoQ mediates virulence in Pseudomonas aeruginosa.
  6. Pseudomons antibiotic resistance is regulated by the PhoP-PhoQ and PmrA-PmrB two-component regulatory systems.
    Title: Contribution of the PhoP-PhoQ and PmrA-PmrB two-component regulatory systems to Mg2+-induced gene regulation in Pseudomonas aeruginosa.
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Homology

Gene Ontology Provided by PseudoCAP

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphorelay sensor kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein histidine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity, transferring phosphorus-containing groups IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in phosphorelay signal transduction system IEA
Inferred from Electronic Annotation
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
two-component sensor PhoQ
NP_249871.1
  • Product name confidence: class 1 (Function experimentally demonstrated in P. aeruginosa)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_002516.2 Reference assembly

    Range
    1278362..1279708
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_249871.1 two-component sensor PhoQ [Pseudomonas aeruginosa PAO1]

    See identical proteins and their annotated locations for NP_249871.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    G9JL92
    Conserved Domains (1) summary
    PRK10815
    Location:190 → 446
    PRK10815; two-component system sensor histidine kinase PhoQ
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9I4F8.1

Gene LinkOut

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Molecular Biology Databases
Research Materials