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PA2018 multidrug efflux protein [ Pseudomonas aeruginosa PAO1 ]

Gene ID: 878882, updated on 23-Apr-2026
Gene symbol
PA2018
Gene description
multidrug efflux protein
Locus tag
PA2018
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Pseudomonas aeruginosa PAO1 (strain: PAO1)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas
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Sequence:
NC_002516.2 (2208169..2211306, complement)

NC_002516.2Genomic Context describing neighboring genes Neighboring gene liu genes regulator Neighboring gene hypothetical protein Neighboring gene multidrug efflux lipoprotein Neighboring gene transcriptional regulator

Genomic Sequence:
NC_002516.2

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Expression in Escherichia coli of a new multidrug efflux pump, MexXY, from Pseudomonas aeruginosa. Mine T, et al. Antimicrob Agents Chemother, 1999 Feb. PMID 9925549, Free PMC Article
  2. MexY-promoted aminoglycoside resistance in Pseudomonas aeruginosa: involvement of a putative proximal binding pocket in aminoglycoside recognition. Lau CH, et al. mBio, 2014 Apr 22. PMID 24757215, Free PMC Article
  3. Contribution of the MexXY multidrug efflux pump and other chromosomal mechanisms on aminoglycoside resistance in Pseudomonas aeruginosa isolates from canine and feline infections. Poonsuk K, et al. J Vet Med Sci, 2012 Dec. PMID 22813987
  4. Induction of the MexXY efflux pump in Pseudomonas aeruginosa is dependent on drug-ribosome interaction. Jeannot K, et al. J Bacteriol, 2005 Aug. PMID 16030228, Free PMC Article
  5. Contribution of the MexX-MexY-oprM efflux system to intrinsic resistance in Pseudomonas aeruginosa. Masuda N, et al. Antimicrob Agents Chemother, 2000 Sep. PMID 10952562, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mutations in the efflux pump regulator MexZ shift tissue colonization by Pseudomonas aeruginosa to a state of antibiotic tolerance.
    Title: Mutations in the efflux pump regulator MexZ shift tissue colonization by Pseudomonas aeruginosa to a state of antibiotic tolerance.
  2. The Efflux Pump MexXY/OprM Contributes to the Tolerance and Acquired Resistance of Pseudomonas aeruginosa to Colistin.
    Title: The Efflux Pump MexXY/OprM Contributes to the Tolerance and Acquired Resistance of Pseudomonas aeruginosa to Colistin.
  3. Polymyxin susceptibility in Pseudomonas aeruginosa is linked to the MexXY-OprM multidrug efflux system.
    Title: Polymyxin Susceptibility in Pseudomonas aeruginosa Linked to the MexXY-OprM Multidrug Efflux System.
  4. The mechanism of development from sensitivity to resistance of P. aeruginosa to carbapenem during carbapenem treatment is due to porin oprD2 loss and an increased expression level of MexXY-OprM.
    Title: Detection of drug-resistance mechanism of Pseudomonas aeruginosa developing from a sensitive strain to a persister during carbapenem treatment.
  5. Mutations of D133 and Y613 compromised aminoglycoside resistance, while, the K79 mutation enhanced aminoglycoside resistance, confirming a role for this putative proximal binding pocket in aminoglycoside recognition and export.
    Title: MexY-promoted aminoglycoside resistance in Pseudomonas aeruginosa: involvement of a putative proximal binding pocket in aminoglycoside recognition.
  6. The MexXY multidrug efflux pump plays a role in aminoglycoside resistance in the dog and cat P. aeruginosa infection isolates.
    Title: Contribution of the MexXY multidrug efflux pump and other chromosomal mechanisms on aminoglycoside resistance in Pseudomonas aeruginosa isolates from canine and feline infections.
  7. The MexXY multidrug efflux pump was shown to enhance the effect of aminoglycoside modifying enzymes to develop high-level aminoglycoside resistance in Pseudomonas aeruginosa.
    Title: Primary mechanisms mediating aminoglycoside resistance in the multidrug-resistant Pseudomonas aeruginosa clinical isolate PA7.
  8. Induction of MexXY efflux pump expression can be caused by Fmt bypass.
    Title: Fmt bypass in Pseudomonas aeruginosa causes induction of MexXY efflux pump expression.
  9. Gel shift analyses and in vitro transcription assays revealed that interaction between PA5471 and MexZ reduced MexZ DNA-binding ability, leading to mexXY transcription.
    Title: Role of MexZ and PA5471 in transcriptional regulation of mexXY in Pseudomonas aeruginosa.
  10. Antibiotic inducibility of the MexXY Multidrug Efflux System of Pseudomonas aeruginosa requires the antibiotic-inducible PA5471 gene product which directly or indirectly modulates the MexZ activity.
    Title: Antibiotic inducibility of the MexXY multidrug efflux system of Pseudomonas aeruginosa: involvement of the antibiotic-inducible PA5471 gene product.
Submit: New GeneRIF Correction See all GeneRIFs (12)

Homology

Gene Ontology Provided by PseudoCAP

Function Evidence Code Pubs
enables efflux transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in response to antibiotic EXP
Inferred from Experiment
more info
 PubMed 
involved_in response to antibiotic IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to toxic substance IEA
Inferred from Electronic Annotation
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in xenobiotic transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
multidrug efflux protein
NP_250708.1
  • Product name confidence: class 2 (High similarity to functionally studied protein)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_002516.2 Reference assembly

    Range
    2208169..2211306 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_250708.1 multidrug efflux protein [Pseudomonas aeruginosa PAO1]

    See identical proteins and their annotated locations for NP_250708.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    Q9ZH24
    Conserved Domains (1) summary
    PRK09577
    Location:1 → 1032
    PRK09577; multidrug efflux RND transporter permease subunit
Nucleotide Protein
Heading Accession and Version

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