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tpbA protein tyrosine phosphatase TpbA [ Pseudomonas aeruginosa PAO1 ]

Gene ID: 878776, updated on 19-Nov-2025
Gene symbol
tpbA
Gene description
protein tyrosine phosphatase TpbA
Locus tag
PA3885
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Pseudomonas aeruginosa PAO1 (strain: PAO1)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas
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Sequence:
NC_002516.2 (4350834..4351490)

NC_002516.2Genomic Context describing neighboring genes Neighboring gene short-chain dehydrogenase Neighboring gene hypothetical protein Neighboring gene hypothetical protein Neighboring gene hypothetical protein

Genomic Sequence:
NC_002516.2

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Expression, purification, crystallization and preliminary crystallographic analysis of PA3885 (TpbA) from Pseudomonas aeruginosa PAO1. Yang W, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2010 Nov 1. PMID 21045298, Free PMC Article
  2. Connecting quorum sensing, c-di-GMP, pel polysaccharide, and biofilm formation in Pseudomonas aeruginosa through tyrosine phosphatase TpbA (PA3885). Ueda A, et al. PLoS Pathog, 2009 Jun. PMID 19543378, Free PMC Article
  3. Pseudomonas Genome Database: facilitating user-friendly, comprehensive comparisons of microbial genomes. Winsor GL, et al. Nucleic Acids Res, 2009 Jan. PMID 18978025, Free PMC Article
  4. Defining the Pseudomonas aeruginosa SOS response and its role in the global response to the antibiotic ciprofloxacin. Cirz RT, et al. J Bacteriol, 2006 Oct. PMID 17015649, Free PMC Article
  5. Cystic fibrosis sputum supports growth and cues key aspects of Pseudomonas aeruginosa physiology. Palmer KL, et al. J Bacteriol, 2005 Aug. PMID 16030221, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Single crystals of PA3885 were studied by X-ray crystallography and native diffraction data were collected to 2.8 A resolution
    Title: Expression, purification, crystallization and preliminary crystallographic analysis of PA3885 (TpbA) from Pseudomonas aeruginosa PAO1.
Submit: New GeneRIF Correction

Homology

Gene Ontology Provided by PseudoCAP

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in periplasmic space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in periplasmic space IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
protein tyrosine phosphatase TpbA
NP_252574.1
  • Product name confidence: class 1: Function experimentally demonstrated in P. aeruginosa

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_002516.2 Reference assembly

    Range
    4350834..4351490
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_252574.1 protein tyrosine phosphatase TpbA [Pseudomonas aeruginosa PAO1]

    See identical proteins and their annotated locations for NP_252574.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A367M0K6
    Conserved Domains (1) summary
    COG2365
    Location:24 → 218
    Oca4; Protein tyrosine/serine phosphatase [Signal transduction mechanisms]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9HXC7.1

Gene LinkOut

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Molecular Biology Databases
Research Materials