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fpvA ferripyoverdine receptor [ Pseudomonas aeruginosa PAO1 ]

Gene ID: 878605, updated on 24-Aug-2024

Summary

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Gene symbol
fpvA
Gene description
ferripyoverdine receptor
Locus tag
PA2398
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Pseudomonas aeruginosa PAO1 (strain: PAO1)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas
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Genomic context

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Sequence:
NC_002516.2 (2655187..2657634)

NC_002516.2Genomic Context describing neighboring genes Neighboring gene pyoverdine synthetase F Neighboring gene pyoverdine biosynthesis protein PvdE Neighboring gene pyoverdine synthetase D Neighboring gene pyoverdine biosynthesis protein PvdJ

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_002516.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mechanism of ferripyoverdine uptake by Pseudomonas aeruginosa outer membrane transporter FpvA: no diffusion channel formed at any time during ferrisiderophore uptake. Nader M, et al. Biochemistry, 2011 Apr 5. PMID 21329359
  2. Pyoverdine-mediated iron transport in Pseudomonas aeruginosa: involvement of a high-molecular-mass outer membrane protein. Poole K, et al. FEMS Microbiol Lett, 1991 Feb. PMID 1903349
  3. FpvA bound to non-cognate pyoverdines: molecular basis of siderophore recognition by an iron transporter. Greenwald J, et al. Mol Microbiol, 2009 Jun. PMID 19504741
  4. Distribution and evolution of ferripyoverdine receptors in Pseudomonas aeruginosa. Bodilis J, et al. Environ Microbiol, 2009 Aug. PMID 19397675
  5. Cloning and nucleotide sequence analysis of the ferripyoverdine receptor gene fpvA of Pseudomonas aeruginosa. Poole K, et al. J Bacteriol, 1993 Aug. PMID 8335619, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Genotypic variants of the P. aeruginosa dominant strains can coexist in the chronic colonization in CF patients. These variants can be undetected by RFLP and they might present variable antibiotic susceptibility
    Title: [Polymorphism of mucA and fpvA genes in Pseudomonas aeruginosa isolates from cystic fibrosis patients: co-existence of genetically different variants].
  2. investigation of mechanism of action of FpvA in uptake/transport of ferripyoverdine: cloning of individual domains/peptide fragments of FpvA; reconstitution of recombinant peptides; analysis of function of each domain/peptide
    Title: Mechanism of ferripyoverdine uptake by Pseudomonas aeruginosa outer membrane transporter FpvA: no diffusion channel formed at any time during ferrisiderophore uptake.
  3. involved in iron acquisition
    Title: Distribution and evolution of ferripyoverdine receptors in Pseudomonas aeruginosa.
  4. These data show that interactions between FpvA and TonB1 are required for (ferri)pyoverdine signal transduction, as well as for ferripyoverdine transport.
    Title: Role of TonB1 in pyoverdine-mediated signaling in Pseudomonas aeruginosa.
  5. Ferric-pyoverdines induce common conformational changes in FpvA.
    Title: FpvA bound to non-cognate pyoverdines: molecular basis of siderophore recognition by an iron transporter.
  6. The authors demonstrated that FpvA binds Pvd-Fe but not Pvd and that Pvd did not compete with Pvd-Fe for FpvA binding.
    Title: The metal dependence of pyoverdine interactions with its outer membrane receptor FpvA.
  7. defects in FpvR binding correlated with a substantial drop in yields of the FpvI and to a lesser extent PvdS sigma factors, suggesting that FpvR-bound FpvI and PvdS are stable while free and active sigma factor is prone to turnover
    Title: FpvIR control of fpvA ferric pyoverdine receptor gene expression in Pseudomonas aeruginosa: demonstration of an interaction between FpvI and FpvR and identification of mutations in each compromising this interaction.
  8. The role of iron and pyoveridine in the formation of the FpvA-TonB complex is reported.
    Title: Interaction of TonB with the outer membrane receptor FpvA of Pseudomonas aeruginosa.
  9. Alanine substitutions in three residues, W362, W391, and F795, markedly compromised ferric pyoverdine binding and transport, consistent with a role of FpvA in ferric pyoverdine recognition.
    Title: FpvA-mediated ferric pyoverdine uptake in Pseudomonas aeruginosa: identification of aromatic residues in FpvA implicated in ferric pyoverdine binding and transport.
  10. Several crystallization conditions of FpvA-Pvd-Fe solubilized in C8E4 detergent were obtained and X-ray data were collected from three crystal forms.
    Title: Preliminary X-ray investigations of several crystal forms of the ferripyoverdine FpvA outer membrane receptor from Pseudomonas aeruginosa bound to ferripyoverdine.
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General gene information

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Homology

Gene Ontology Provided by PseudoCAP

Function Evidence Code Pubs
enables signaling receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables signaling receptor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables signaling receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within pyoverdine biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
ferripyoverdine receptor
NP_251088.1
  • Product name confidence: class 1 (Function experimentally demonstrated in P. aeruginosa)

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_002516.2 Reference assembly

    Range
    2655187..2657634
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_251088.1 ferripyoverdine receptor [Pseudomonas aeruginosa PAO1]

    See identical proteins and their annotated locations for NP_251088.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A5E5QUR1
    Conserved Domains (1) summary
    COG4773
    Location:76 → 815
    FhuE; Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P48632.2

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Molecular Biology Databases