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algL alginate lyase [ Pseudomonas aeruginosa PAO1 ]

Gene ID: 878552, updated on 30-Jul-2025
Gene symbol
algL
Gene description
alginate lyase
Locus tag
PA3547
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Pseudomonas aeruginosa PAO1 (strain: PAO1)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas
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Sequence:
NC_002516.2 (3973014..3974117)

NC_002516.2Genomic Context describing neighboring genes Neighboring gene alginate-c5-mannuronan-epimerase AlgG Neighboring gene alginate biosynthesis protein AlgX Neighboring gene alginate o-acetylase AlgI Neighboring gene alginate o-acetylase AlgJ

Genomic Sequence:
NC_002516.2

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Expression, purification, crystallization and preliminary X-ray analysis of Pseudomonas aeruginosa AlgL. Wolfram F, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2012 May 1. PMID 22691793, Free PMC Article
  2. Alginate lyase (AlgL) activity is required for alginate biosynthesis in Pseudomonas aeruginosa. Albrecht MT, et al. J Bacteriol, 2005 Jun. PMID 15901714, Free PMC Article
  3. Sequence of the algL gene of Pseudomonas aeruginosa and purification of its alginate lyase product. Boyd A, et al. Gene, 1993 Sep 6. PMID 8370530
  4. Alginate synthesis in Pseudomonas aeruginosa: the role of AlgL (alginate lyase) and AlgX. Monday SR, et al. J Bacteriol, 1996 Feb. PMID 8550492, Free PMC Article
  5. Pseudomonas Genome Database: facilitating user-friendly, comprehensive comparisons of microbial genomes. Winsor GL, et al. Nucleic Acids Res, 2009 Jan. PMID 18978025, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. AlgL crystals exhibited the symmetry of space group P2(1)2(1)2(1) and diffracted to a minimum d-spacing of 1.64 A
    Title: Expression, purification, crystallization and preliminary X-ray analysis of Pseudomonas aeruginosa AlgL.
  2. the enzymatic activity of AlgL is required for alginate production
    Title: Alginate lyase (AlgL) activity is required for alginate biosynthesis in Pseudomonas aeruginosa.
Submit: New GeneRIF Correction

Homology

Gene Ontology Provided by PseudoCAP

Function Evidence Code Pubs
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables poly(beta-D-mannuronate) lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables threonine deaminase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in alginic acid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in alginic acid catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in alginic acid catabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in periplasmic space IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
alginate lyase
NP_252237.1
  • Product name confidence: class 1 (Function experimentally demonstrated in P. aeruginosa)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_002516.2 Reference assembly

    Range
    3973014..3974117
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_252237.1 alginate lyase [Pseudomonas aeruginosa PAO1]

    See identical proteins and their annotated locations for NP_252237.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A2U8U7V5
    Conserved Domains (1) summary
    cd00244
    Location:24 → 361
    AlgLyase; Alginate Lyase A1-III; enzymatically depolymerizes alginate, a complex copolymer of beta-D-mannuronate and alpha-L-guluronate, by cleaving the beta-(1,4) glycosidic bond.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q06749.2

Gene LinkOut

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Molecular Biology Databases