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sigX RNA polymerase sigma factor SigX [ Pseudomonas aeruginosa PAO1 ]

Gene ID: 878527, updated on 30-Jul-2025
Gene symbol
sigX
Gene description
RNA polymerase sigma factor SigX
Locus tag
PA1776
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Pseudomonas aeruginosa PAO1 (strain: PAO1)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas
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Sequence:
NC_002516.2 (1920568..1921065)

NC_002516.2Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene hypothetical protein Neighboring gene outer membrane porin F Neighboring gene uroporphyrin-III C-methyltransferase

Genomic Sequence:
NC_002516.2

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. The absence of SigX results in impaired carbon metabolism and membrane fluidity in Pseudomonas aeruginosa. Fléchard M, et al. Sci Rep, 2018 Nov 21. PMID 30464317, Free PMC Article
  2. A proteomic approach of SigX function in Pseudomonas aeruginosa outer membrane composition. Duchesne R, et al. J Proteomics, 2013 Dec 6. PMID 24332064
  3. Transcription of the oprF gene of Pseudomonas aeruginosa is dependent mainly on the SigX sigma factor and is sucrose induced. Bouffartigues E, et al. J Bacteriol, 2012 Aug. PMID 22685281, Free PMC Article
  4. Influence of a putative ECF sigma factor on expression of the major outer membrane protein, OprF, in Pseudomonas aeruginosa and Pseudomonas fluorescens. Brinkman FS, et al. J Bacteriol, 1999 Aug. PMID 10438740, Free PMC Article
  5. Pseudomonas Genome Database: facilitating user-friendly, comprehensive comparisons of microbial genomes. Winsor GL, et al. Nucleic Acids Res, 2009 Jan. PMID 18978025, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Altogether, these data suggest that SigX is indirectly involved in carbon catabolite repression regulation, possibly via its effects on membrane integrity and fluidity.
    Title: The absence of SigX results in impaired carbon metabolism and membrane fluidity in Pseudomonas aeruginosa.
  2. The data presented here suggest that SigX is involved in the outer membrane protein composition, and could be linked to a regulatory network involved in OM homeostasis.
    Title: A proteomic approach of SigX function in Pseudomonas aeruginosa outer membrane composition.
  3. oprF transcription was increased in response to low NaCl or high sucrose concentrations, and this induced transcription was strongly impaired in the absence of SigX.
    Title: Transcription of the oprF gene of Pseudomonas aeruginosa is dependent mainly on the SigX sigma factor and is sucrose induced.
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Homology

Gene Ontology Provided by PseudoCAP

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables sigma factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables sigma factor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA-templated transcription initiation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of cell growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of DNA-templated transcription initiation IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
RNA polymerase sigma factor SigX
NP_250467.1
  • Product name confidence: class 1 (Function experimentally demonstrated in P. aeruginosa)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_002516.2 Reference assembly

    Range
    1920568..1921065
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_250467.1 RNA polymerase sigma factor SigX [Pseudomonas aeruginosa PAO1]

    See identical proteins and their annotated locations for NP_250467.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    Q9I2W5
    Conserved Domains (1) summary
    PRK09640
    Location:2 → 165
    PRK09640; RNA polymerase sigma factor SigX; Reviewed
Nucleotide Protein
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