U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

phoB two-component response regulator PhoB [ Pseudomonas aeruginosa PAO1 ]

Gene ID: 878438, updated on 11-Sep-2024

Summary

Go to the top of the page Help
Gene symbol
phoB
Gene description
two-component response regulator PhoB
Locus tag
PA5360
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Pseudomonas aeruginosa PAO1 (strain: PAO1)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Sequence:
NC_002516.2 (6026779..6027468)

NC_002516.2Genomic Context describing neighboring genes Neighboring gene 4-hydroxybenzoate octaprenyltransferase Neighboring gene hypothetical protein Neighboring gene two-component sensor PhoR Neighboring gene hypothetical protein

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_002516.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Cross talk between the response regulators PhoB and TctD allows for the integration of diverse environmental signals in Pseudomonas aeruginosa. Bielecki P, et al. Nucleic Acids Res, 2015 Jul 27. PMID 26082498, Free PMC Article
  2. The effect of pstS and phoB on quorum sensing and swarming motility in Pseudomonas aeruginosa. Blus-Kadosh I, et al. PLoS One, 2013. PMID 24023943, Free PMC Article
  3. Phosphate starvation relayed by PhoB activates the expression of the Pseudomonas aeruginosa σvreI ECF factor and its target genes. Faure LM, et al. Microbiology (Reading), 2013 Jul. PMID 23657684
  4. Expression of the Pho regulon negatively regulates biofilm formation by Pseudomonas aureofaciens PA147-2. Monds RD, et al. Mol Microbiol, 2001 Oct. PMID 11703664
  5. Exopolyphosphatase of Pseudomonas aeruginosa is essential for the production of virulence factors, and its expression is controlled by NtrC and PhoB acting at two interspaced promoters. Gallarato LA, et al. Microbiology (Reading), 2014 Feb. PMID 24275100

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The results on the PhoB and TctD mediated two-component signal transduction pathways exemplify how P. aeruginosa may exploit cross-regulation to adapt bacterial behavior to complex environments.
    Title: Cross talk between the response regulators PhoB and TctD allows for the integration of diverse environmental signals in Pseudomonas aeruginosa.
  2. Under nitrogen-limiting conditions, expression of ppx was controlled from a sigma(54)-dependent promoter activated by the response regulator NtrC, while under Pi limitation, the expression was controlled from a sigma(70) promoter, activated by PhoB.
    Title: Exopolyphosphatase of Pseudomonas aeruginosa is essential for the production of virulence factors, and its expression is controlled by NtrC and PhoB acting at two interspaced promoters.
  3. Phosphate starvation relayed by PhoB activates the expression of the Pseudomonas aeruginosa sigmavreI ECF factor and its target genes.
    Title: Phosphate starvation relayed by PhoB activates the expression of the Pseudomonas aeruginosa σvreI ECF factor and its target genes.
Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by PseudoCAP

Function Evidence Code Pubs
enables phosphorelay response regulator activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within bacterial-type flagellum-dependent swarming motility IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of cellular response to phosphate starvation IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
two-component response regulator PhoB
NP_254047.1
  • Product name confidence: class 1 (Function experimentally demonstrated in P. aeruginosa)

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_002516.2 Reference assembly

    Range
    6026779..6027468
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_254047.1 two-component response regulator PhoB [Pseudomonas aeruginosa PAO1]

    See identical proteins and their annotated locations for NP_254047.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P23620
    Conserved Domains (1) summary
    TIGR02154
    Location:2 → 226
    PhoB; phosphate regulon transcriptional regulatory protein PhoB
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P23620.2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials