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pilA type 4 fimbrial protein PilA [ Pseudomonas aeruginosa PAO1 ]

Gene ID: 878423, updated on 19-Nov-2025
Gene symbol
pilA
Gene description
type 4 fimbrial protein PilA
Locus tag
PA4525
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Pseudomonas aeruginosa PAO1 (strain: PAO1)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas
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Sequence:
NC_002516.2 (5069082..5069531, complement)

NC_002516.2Genomic Context describing neighboring genes Neighboring gene nicotinate-nucleotide pyrophosphorylase Neighboring gene tRNA-Thr Neighboring gene type 4 fimbrial biogenesis protein PilB Neighboring gene pseudo

Genomic Sequence:
NC_002516.2

Go to nucleotide: Graphics FASTA GenBank

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Glycosylation of type 4 fimbrial protein (PilA) protect Pseudomonas aeruginosa from certain pilus-specific phages. Alterations to PilA sequence can block phage infection, but glycosylation is less likely to create disadvantageous phenotypes. Through construction of chimeric phages, specific phage tail proteins allow infection of P. aeruginosa strains with glycosylated pili.
    Title: Pseudomonas aeruginosa defends against phages through type IV pilus glycosylation.
  2. PilS's phosphatase motif was required for the autoregulation of pilA transcription, suggesting that under conditions where PilA is abundant, the PilA-PilS interaction promotes PilR dephosphorylation and thus down-regulation of further pilA transcription.
    Title: Type IV pilins regulate their own expression via direct intramembrane interactions with the sensor kinase PilS.
  3. Data show that the type IV pilus (Tfp)-deficient mutant DeltapilA is severely attenuated in an acute pneumonia model of infection in the lungs of wild-type mice, but is virulent in the lungs of surfactant protein-A SP-A(-/-) mice.
    Title: Type IV pilus of Pseudomonas aeruginosa confers resistance to antimicrobial activities of the pulmonary surfactant protein-A.
  4. Found that the calcium-modulating cyclophilin ligand (CAMLG), which is involved in Ca(2+) signaling, was the major host cell PilA binding protein.
    Title: Type IV pilus protein PilA of Pseudomonas aeruginosa modulates calcium signaling through binding the calcium-modulating cyclophilin ligand.
  5. PilA, the major pilin subunit, interacts with PilNOPQ. The results allow us to propose a model whereby PilA makes extensive contacts with the transenvelope complex, possibly to increase local concentrations of PilA monomers for polymerization.
    Title: PilMNOPQ from the Pseudomonas aeruginosa type IV pilus system form a transenvelope protein interaction network that interacts with PilA.
Submit: New GeneRIF Correction

Homology

Gene Ontology Provided by PseudoCAP

Process Evidence Code Pubs
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in cell adhesion involved in single-species biofilm formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of calcium-mediated signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in single-species biofilm formation on inanimate substrate IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in type IV pilus-dependent motility IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in type IV pilus-dependent motility IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cell surface IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in host cell endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in pilus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in pilus IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in type IV pilus IDA
Inferred from Direct Assay
more info
 PubMed 
Preferred Names
type 4 fimbrial protein PilA
NP_253215.1
  • Product name confidence: class 1 (Function experimentally demonstrated in P. aeruginosa)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_002516.2 Reference assembly

    Range
    5069082..5069531 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_253215.1 type 4 fimbrial protein PilA [Pseudomonas aeruginosa PAO1]

    See identical proteins and their annotated locations for NP_253215.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    Q93PL8
    Conserved Domains (1) summary
    COG4969
    Location:1 → 134
    PilA; Tfp pilus assembly protein, major pilin PilA [Cell motility, Extracellular structures]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P04739.1

Gene LinkOut

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Molecular Biology Databases
Research Materials