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exoT exoenzyme T [ Pseudomonas aeruginosa PAO1 ]

Gene ID: 878350, updated on 6-Jul-2026
Gene symbol
exoT
Gene description
exoenzyme T
Locus tag
PA0044
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Pseudomonas aeruginosa PAO1 (strain: PAO1)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas
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Sequence:
NC_002516.2 (58786..60159)

NC_002516.2Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene hypothetical protein Neighboring gene hypothetical protein Neighboring gene hypothetical protein

Genomic Sequence:
NC_002516.2

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Pseudomonas aeruginosa ExoT Induces Atypical Anoikis Apoptosis in Target Host Cells by Transforming Crk Adaptor Protein into a Cytotoxin. Wood S, et al. PLoS Pathog, 2015 May. PMID 26020630, Free PMC Article
  2. Interfacial residues of SpcS chaperone affects binding of effector toxin ExoT in Pseudomonas aeruginosa: novel insights from structural and computational studies. Dey S, et al. FEBS J, 2014 Feb. PMID 24387107
  3. Pseudomonas aeruginosa ExoT Induces Mitochondrial Apoptosis in Target Host Cells in a Manner That Depends on Its GTPase-activating Protein (GAP) Domain Activity. Wood SJ, et al. J Biol Chem, 2015 Nov 27. PMID 26451042, Free PMC Article
  4. The Pseudomonas aeruginosa type III secreted toxin ExoT is necessary and sufficient to induce apoptosis in epithelial cells. Shafikhani SH, et al. Cell Microbiol, 2008 Apr. PMID 18053004, Free PMC Article
  5. Exoenzyme T of Pseudomonas aeruginosa elicits cytotoxicity without interfering with Ras signal transduction. Sundin C, et al. Cell Microbiol, 2001 Apr. PMID 11298647

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Together, the ADPRT and the GAP domains make ExoT into a highly versatile and potent cytotoxin, capable of inducing multiple forms of apoptosis in target host cells.
    Title: Pseudomonas aeruginosa ExoT Induces Mitochondrial Apoptosis in Target Host Cells in a Manner That Depends on Its GTPase-activating Protein (GAP) Domain Activity.
  2. findings demonstrate the pathogenesis of P. aeruginosa keratitis in ExoS- and ExoT-producing strains is almost entirely due to their ADPR activities, which subvert the host response by targeting the antibacterial activity of infiltrating neutrophils
    Title: ExoS and ExoT ADP ribosyltransferase activities mediate Pseudomonas aeruginosa keratitis by promoting neutrophil apoptosis and bacterial survival.
  3. Data demonstrate that ExoT is both necessary and sufficient to cause apoptosis in HeLa cells and that it activates the mitochondrial/cytochrome c-dependent apoptotic pathway.
    Title: The Pseudomonas aeruginosa type III secreted toxin ExoT is necessary and sufficient to induce apoptosis in epithelial cells.
  4. Role in systemic spread of Pseudomonas aeruginosa PAO1 in vivo.
    Title: Role of the type III secreted exoenzymes S, T, and Y in systemic spread of Pseudomonas aeruginosa PAO1 in vivo.
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Homology

Gene Ontology Provided by PseudoCAP

Function Evidence Code Pubs
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
  
enables NAD+-protein-arginine ADP-ribosyltransferase activity EXP
Inferred from Experiment
more info
 PubMed 
enables NAD+-protein-arginine ADP-ribosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in symbiont-mediated disruption of host focal adhesion EXP
Inferred from Experiment
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region EXP
Inferred from Experiment
more info
 PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
exoenzyme T
NP_248734.1
  • Product name confidence: class 1 (Function experimentally demonstrated in P. aeruginosa)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_002516.2 Reference assembly

    Range
    58786..60159
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_248734.1 exoenzyme T [Pseudomonas aeruginosa PAO1]

    See identical proteins and their annotated locations for NP_248734.1

    Status: PROVISIONAL

    Conserved Domains (1) summary
    COG5585
    Location:7 → 450
    COG5585; NAD+--asparagine ADP-ribosyltransferase [Signal transduction mechanisms]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9I788.1

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