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oxyR transcriptional regulator [ Pseudomonas aeruginosa PAO1 ]

Gene ID: 878254, updated on 19-Nov-2025
Gene symbol
oxyR
Gene description
transcriptional regulator
Locus tag
PA5344
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Pseudomonas aeruginosa PAO1 (strain: PAO1)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas
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Sequence:
NC_002516.2 (6012047..6012979)

NC_002516.2Genomic Context describing neighboring genes Neighboring gene transcriptional regulator Neighboring gene hypothetical protein Neighboring gene ATP-dependent DNA helicase RecG Neighboring gene hypothetical protein Neighboring gene hypothetical protein

Genomic Sequence:
NC_002516.2

Go to nucleotide: Graphics FASTA GenBank

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. hypothesized that OxyR can be reduced by DsbM, and thus DsbM may be required for aminoglycoside resistance in P. aeruginosa.
    Title: DsbM affects aminoglycoside resistance in Pseudomonas aeruginosa by the reduction of OxyR.
  2. Collectively, the results indicate that OxyR is involved in oxidative stress defense and regulates other aspects of cellular metabolism as well.
    Title: Global regulation of gene expression by OxyR in an important human opportunistic pathogen.
  3. Results describe the effects caused by iron limitation on the physiological proteomic response of the oxyR mutant in Pseudomonas aeruginosa.
    Title: A proteome analysis of the response of a Pseudomonas aeruginosa oxyR mutant to iron limitation.
  4. Mutation in OxyR causes an increase of pyocyanin production, strongly decreased swarming motility, and absence of rhamnolipid production.
    Title: The Pseudomonas aeruginosa oxidative stress regulator OxyR influences production of pyocyanin and rhamnolipids: protective role of pyocyanin.
  5. Inactivation of the oxyR gene in Pseudomonas aeruginosa PAO1 impairs pyoverdine-mediated iron uptake and growth under iron limited conditions.
    Title: Loss of the oxidative stress regulator OxyR in Pseudomonas aeruginosa PAO1 impairs growth under iron-limited conditions.
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Homology

Gene Ontology Provided by PseudoCAP

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific DNA binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of secondary metabolite biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of cell motility IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of lipid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of superoxide dismutase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA-templated transcription EXP
Inferred from Experiment
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of response to reactive oxygen species IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of protein-DNA complex IPI
Inferred from Physical Interaction
more info
 PubMed 
Preferred Names
transcriptional regulator
NP_254031.1
  • Product name confidence: class 1: Function experimentally demonstrated in P. aeruginosa

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_002516.2 Reference assembly

    Range
    6012047..6012979
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_254031.1 transcriptional regulator [Pseudomonas aeruginosa PAO1]

    See identical proteins and their annotated locations for NP_254031.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    Q9HTL4
    Conserved Domains (2) summary
    cd08411
    Location:92 → 293
    PBP2_OxyR; The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily
    pfam00126
    Location:3 → 62
    HTH_1; Bacterial regulatory helix-turn-helix protein, lysR family
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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Molecular Biology Databases
Research Materials