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crc catabolite repression control protein [ Pseudomonas aeruginosa PAO1 ]

Gene ID: 878037, updated on 19-Nov-2025
Gene symbol
crc
Gene description
catabolite repression control protein
Locus tag
PA5332
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Pseudomonas aeruginosa PAO1 (strain: PAO1)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas
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Sequence:
NC_002516.2 (6002121..6002900)

NC_002516.2Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene hypothetical protein Neighboring gene orotate phosphoribosyltransferase Neighboring gene hypothetical protein Neighboring gene ribonuclease PH

Genomic Sequence:
NC_002516.2

Go to nucleotide: Graphics FASTA GenBank

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Stabilization of Hfq-mediated translational repression by the co-repressor Crc in Pseudomonas aeruginosa.
    Title: Stabilization of Hfq-mediated translational repression by the co-repressor Crc in Pseudomonas aeruginosa.
  2. Crc orchestrates the overall response of P. aeruginosa to oxidative stress
    Title: The global regulator Crc orchestrates the metabolic robustness underlying oxidative stress resistance in Pseudomonas aeruginosa.
  3. We describe high-resolution cryo-EM structures of the assembly of Hfq and Crc bound to the translation initiation site of a target mRNA. The core of the assembly is formed through interactions of two cognate RNAs, two Hfq hexamers and a Crc pair.
    Title: Architectural principles for Hfq/Crc-mediated regulation of gene expression.
  4. It has been shown that Crc and Hfq form an assembly in the presence of RNAs containing A-rich motifs, and that Crc interacts with both, Hfq and RNA. Through these interactions, Crc enhances the stability of Hfq/Crc/RNA complexes, which can explain its facilitating role in Hfq-mediated translational repression.
    Title: Interplay between the catabolite repression control protein Crc, Hfq and RNA in Hfq-dependent translational regulation in Pseudomonas aeruginosa.
  5. This study therefore uncovers a novel posttranscriptional regulatory cascade, Crc-Hfq/Lon/RhlI, for the regulation of rhamnolipid production and rhl quorum sensing in Pseudomonas aeruginosa.
    Title: The Crc protein participates in down-regulation of the Lon gene to promote rhamnolipid production and rhl quorum sensing in Pseudomonas aeruginosa.
  6. Crc protein from P. aeruginosa does not display DNase activity, nor does it bind to previously identified RNA substrates.
    Title: The Pseudomonas aeruginosa catabolite repression control protein Crc is devoid of RNA binding activity.
  7. Crc may exert multifaceted control on the type III secretion system through various pathways, which may serve to fine-tune this virulence mechanism in response to environmental changes and nutrient sources.
    Title: The global regulator Crc plays a multifaceted role in modulation of type III secretion system in Pseudomonas aeruginosa.
  8. Crc protein repressed the formation of the blue pigment pyocyanin in response to a preferred carbon source (succinate) by interacting with phzM mRNA, which encodes a key enzyme in pyocyanin biosynthesis.
    Title: Catabolite repression control of pyocyanin biosynthesis at an intersection of primary and secondary metabolism in Pseudomonas aeruginosa.
Submit: New GeneRIF Correction

Homology

Gene Ontology Provided by PseudoCAP

Function Evidence Code Pubs
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables double-stranded DNA 3'-5' DNA exonuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nuclease activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in quorum sensing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of carbon utilization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of single-species biofilm formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Preferred Names
catabolite repression control protein
NP_254019.1
  • Product name confidence: class 1 (Function experimentally demonstrated in P. aeruginosa)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_002516.2 Reference assembly

    Range
    6002121..6002900
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_254019.1 catabolite repression control protein [Pseudomonas aeruginosa PAO1]

    See identical proteins and their annotated locations for NP_254019.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    G3XDB0, Q51380
    Conserved Domains (1) summary
    cd10281
    Location:1 → 253
    Nape_like_AP-endo; Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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Molecular Biology Databases
Research Materials