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RIOK3 RIO kinase 3 [ Homo sapiens (human) ]

Gene ID: 8780, updated on 21-Dec-2019

Summary

Official Symbol
RIOK3provided by HGNC
Official Full Name
RIO kinase 3provided by HGNC
Primary source
HGNC:HGNC:11451
See related
Ensembl:ENSG00000101782 MIM:603579
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SUDD
Summary
This gene was first identified by the similarity of its product to the Aspergillus nidulans SUDD protein. This gene is now recognized as a member of the right open reading frame (RIO) kinase gene family. This gene encodes a serine/threonine kinase that localizes to the cytoplasm and plays a role in the processing of the pre-40 S ribosomal subunit. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2017]
Expression
Ubiquitous expression in bone marrow (RPKM 81.4), esophagus (RPKM 38.1) and 24 other tissues See more
Orthologs

Genomic context

See RIOK3 in Genome Data Viewer
Location:
18q11.2
Exon count:
12
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 18 NC_000018.10 (23452823..23483140)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (21032787..21063104)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 2761 Neighboring gene Cdk5 and Abl enzyme substrate 1 Neighboring gene transmembrane protein 241 Neighboring gene regulator of MON1-CCZ1 Neighboring gene NPC intracellular cholesterol transporter 1 Neighboring gene ankyrin repeat domain 29

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp779L1370

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
caspase binding IDA
Inferred from Direct Assay
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
cellular response to dsDNA IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to dsRNA IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to virus IMP
Inferred from Mutant Phenotype
more info
PubMed 
chromosome segregation TAS
Traceable Author Statement
more info
PubMed 
defense response to virus IEA
Inferred from Electronic Annotation
more info
 
innate immune response IEA
Inferred from Electronic Annotation
more info
 
maturation of SSU-rRNA IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
maturation of SSU-rRNA IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of I-kappaB kinase/NF-kappaB signaling IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of MDA-5 signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of protein homooligomerization IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of innate immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of interferon-beta production IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
preribosome, small subunit precursor IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
preribosome, small subunit precursor IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
serine/threonine-protein kinase RIO3
Names
homolog of the Aspergillus nidulans sudD gene product
sudD (suppressor of bimD6, Aspergillus nidulans) homolog
sudD homolog
sudD suppressor of Aspergillus nidulans bimD6 homolog
sudD suppressor of bimD6 homolog
testicular secretory protein Li 47
NP_001335122.1
NP_003822.2
XP_011524544.1
XP_011524545.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001348193.2NP_001335122.1  serine/threonine-protein kinase RIO3 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC026634, AK057292
    Consensus CDS
    CCDS86664.1
    UniProtKB/TrEMBL
    B0YJ89, B4E1Q4
    Related
    ENSP00000463660.1, ENST00000581585.5
    Conserved Domains (1) summary
    cd05146
    Location:237437
    RIO3_euk; Catalytic domain of the atypical protein serine kinase, RIO3 kinase
  2. NM_003831.5NP_003822.2  serine/threonine-protein kinase RIO3 isoform 1

    See identical proteins and their annotated locations for NP_003822.2

    Status: REVIEWED

    Source sequence(s)
    AC026634, AK057292
    Consensus CDS
    CCDS11877.1
    UniProtKB/Swiss-Prot
    O14730
    UniProtKB/TrEMBL
    B0YJ89
    Related
    ENSP00000341874.3, ENST00000339486.8
    Conserved Domains (2) summary
    COG1718
    Location:214465
    RIO1; Serine/threonine-protein kinase RIO1 [Signal transduction mechanisms]
    cd05146
    Location:253453
    RIO3_euk; Catalytic domain of the atypical protein serine kinase, RIO3 kinase

RNA

  1. NR_145477.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC026634
    Related
    ENST00000581302.5

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p13 Primary Assembly

    Range
    23452823..23483140
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011526243.1XP_011524545.1  serine/threonine-protein kinase RIO3 isoform X2

    Conserved Domains (1) summary
    cl21453
    Location:69197
    PKc_like; Protein Kinases, catalytic domain
  2. XM_011526242.1XP_011524544.1  serine/threonine-protein kinase RIO3 isoform X1

    Conserved Domains (1) summary
    cd05146
    Location:15202
    RIO3_euk; Catalytic domain of the atypical protein serine kinase, RIO3 kinase

RNA

  1. XR_002958189.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_145906.1: Suppressed sequence

    Description
    NM_145906.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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