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retS sensor histidine kinase MifS [ Pseudomonas aeruginosa PAO1 ]

Gene ID: 877881, updated on 24-Aug-2024

Summary

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Gene symbol
retS
Gene description
sensor histidine kinase MifS
Locus tag
PA4856
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Pseudomonas aeruginosa PAO1 (strain: PAO1)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas
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Genomic context

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Sequence:
NC_002516.2 (5452150..5454978)

NC_002516.2Genomic Context describing neighboring genes Neighboring gene bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase Neighboring gene phosphoribosylamine--glycine ligase Neighboring gene hypothetical protein Neighboring gene hypothetical protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_002516.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mucin Glycans Signal through the Sensor Kinase RetS to Inhibit Virulence-Associated Traits in Pseudomonas aeruginosa. Wang BX, et al. Curr Biol, 2021 Jan 11. PMID 33125866, Free PMC Article
  2. Distinct oligomeric forms of the Pseudomonas aeruginosa RetS sensor domain modulate accessibility to the ligand binding site. Vincent F, et al. Environ Microbiol, 2010 Jun. PMID 20553556
  3. Helix Cracking Regulates the Critical Interaction between RetS and GacS in Pseudomonas aeruginosa. Mancl JM, et al. Structure, 2019 May 7. PMID 30879888
  4. Multiple communication mechanisms between sensor kinases are crucial for virulence in Pseudomonas aeruginosa. Francis VI, et al. Nat Commun, 2018 Jun 7. PMID 29880803, Free PMC Article
  5. Characterization of the Direct Interaction between Hybrid Sensor Kinases PA1611 and RetS That Controls Biofilm Formation and the Type III Secretion System in Pseudomonas aeruginosa. Bhagirath AY, et al. ACS Infect Dis, 2017 Feb 10. PMID 27957853

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. RetS inhibits Pseudomonas aeruginosa biofilm formation by disrupting the canonical histidine kinase dimerization interface of GacS.
    Title: RetS inhibits Pseudomonas aeruginosa biofilm formation by disrupting the canonical histidine kinase dimerization interface of GacS.
  2. Mucin Glycans Signal through the Sensor Kinase RetS to Inhibit Virulence-Associated Traits in Pseudomonas aeruginosa.
    Title: Mucin Glycans Signal through the Sensor Kinase RetS to Inhibit Virulence-Associated Traits in Pseudomonas aeruginosa.
  3. x-ray crystallography reveals that RetS uses the reversible unfolding of a helix, or helix cracking, to control interactions with GacS
    Title: Helix Cracking Regulates the Critical Interaction between RetS and GacS in Pseudomonas aeruginosa.
  4. Study interactions between two sensor kinases from Pseudomonas aeruginosa, GacS and RetS, which control the switch between acute and chronic virulence demonstrate three mechanisms by which RetS attenuates GacS signalling: RetS takes phosphoryl groups from GacS-P; RetS has transmitter phosphatase activity against the receiver domain of GacS-P; and RetS inhibits GacS autophosphorylation.
    Title: Multiple communication mechanisms between sensor kinases are crucial for virulence in Pseudomonas aeruginosa.
  5. Results from functional studies using RetS identified residues R567 and Q624 to be predominantly involved in the PA1611-RetS interaction and as having a significant effect on the phenotypes.
    Title: Characterization of the Direct Interaction between Hybrid Sensor Kinases PA1611 and RetS That Controls Biofilm Formation and the Type III Secretion System in Pseudomonas aeruginosa.
  6. Independent of phosphate relay, PA1611 interacts directly with RetS in vivo.
    Title: Hybrid sensor kinase PA1611 in Pseudomonas aeruginosa regulates transitions between acute and chronic infection through direct interaction with RetS.
  7. RetS signalling antagonistically controls the type III and type VI secretion systems. The retS mutant displays elevated levels of c-di-GMP.
    Title: The Pseudomonas aeruginosa sensor RetS switches type III and type VI secretion via c-di-GMP signalling.
  8. Data suggest that PhoPQ controls the equilibrium of the small regulatory RNAs and thus fine-tunes the expression of genes in the RetS pathway.
    Title: Magnesium limitation is an environmental trigger of the Pseudomonas aeruginosa biofilm lifestyle.
  9. The study shows that RetS controls both rsmY and rsmZ small RNA expression, whereas HptB exclusively regulates rsmY expression.
    Title: Regulatory RNAs and the HptB/RetS signalling pathways fine-tune Pseudomonas aeruginosa pathogenesis.
  10. Data highlight the modular architecture and assembly of the RetSp fold and give clues on how homodimerization of RetS could be modulated upon ligand binding to control formation of a RetS/GacS heterodimer.
    Title: Distinct oligomeric forms of the Pseudomonas aeruginosa RetS sensor domain modulate accessibility to the ligand binding site.
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General gene information

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Homology

General protein information

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Preferred Names
sensor histidine kinase MifS
NP_253543.1
  • Product name confidence: class 1 (Function experimentally demonstrated in P. aeruginosa)

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_002516.2 Reference assembly

    Range
    5452150..5454978
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_253543.1 sensor histidine kinase MifS [Pseudomonas aeruginosa PAO1]

    See identical proteins and their annotated locations for NP_253543.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A367M6T6
    Conserved Domains (3) summary
    PRK11107
    Location:402 → 927
    PRK11107; hybrid sensory histidine kinase BarA; Provisional
    pfam07695
    Location:204 → 390
    7TMR-DISM_7TM; 7TM diverse intracellular signalling
    pfam07696
    Location:50 → 172
    7TMR-DISMED2; 7TMR-DISM extracellular 2
Nucleotide Protein
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