U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

ptxS transcriptional regulator PtxS [ Pseudomonas aeruginosa PAO1 ]

Gene ID: 877811, updated on 30-Jul-2025
Gene symbol
ptxS
Gene description
transcriptional regulator PtxS
Locus tag
PA2259
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Pseudomonas aeruginosa PAO1 (strain: PAO1)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas
Try the new Gene page
Try the new Transcripts and proteins table
Sequence:
NC_002516.2 (2487856..2488878)

NC_002516.2Genomic Context describing neighboring genes Neighboring gene paerucumarin biosynthesis protein PvcC Neighboring gene paerucumarin biosynthesis protein PvcD Neighboring gene HTH-type transcriptional regulator PtxR Neighboring gene hypothetical protein Neighboring gene 2-ketogluconate kinase Neighboring gene 2-ketogluconate transporter

Genomic Sequence:
NC_002516.2

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Autoregulation of the Pseudomonas aeruginosa protein PtxS occurs through a specific operator site within the ptxS upstream region. Swanson BL, et al. J Bacteriol, 2000 Aug. PMID 10894751, Free PMC Article
  2. The Pseudomonas aeruginosa exotoxin A regulatory gene, ptxS: evidence for negative autoregulation. Swanson BL, et al. J Bacteriol, 1999 Aug. PMID 10438759, Free PMC Article
  3. Transcriptional analysis of the Pseudomonas aeruginosa toxA regulatory gene ptxR. Colmer-Hamood JA, et al. Can J Microbiol, 2006 Apr. PMID 16699585
  4. The Pseudomonas aeruginosa global regulator MvaT specifically binds to the ptxS upstream region and enhances ptxS expression. Westfall LW, et al. Microbiology (Reading), 2004 Nov. PMID 15528665
  5. Genes for carbon metabolism and the ToxA virulence factor in Pseudomonas aeruginosa are regulated through molecular interactions of PtxR and PtxS. Daddaoua A, et al. PLoS One, 2012. PMID 22844393, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PtxS modulates PtxR activity in response to 2-ketogluconate by complex formation in solution in the case of the P(toxA) promoter, or via the formation of a DNA loop as in the regulation of gluconate catabolic genes
    Title: Genes for carbon metabolism and the ToxA virulence factor in Pseudomonas aeruginosa are regulated through molecular interactions of PtxR and PtxS.
  2. results suggest that MvaT positively regulates ptxS expression by binding specifically to the ptxS upstream region
    Title: The Pseudomonas aeruginosa global regulator MvaT specifically binds to the ptxS upstream region and enhances ptxS expression.
  3. Results indicate that negative regulation of ptxR expression by PtxS does not occur through the PtxS binding site within the ptxR-ptxS intergenic region.
    Title: Transcriptional analysis of the Pseudomonas aeruginosa toxA regulatory gene ptxR.
Submit: New GeneRIF Correction

Homology

Gene Ontology Provided by PseudoCAP

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription repressor activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription repressor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables DNA-binding transcription repressor activity IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription cis-regulatory region binding IEA
Inferred from Electronic Annotation
more info
  
enables transcription cis-regulatory region binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables transcription cis-regulatory region binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of protein-DNA complex IEA
Inferred from Electronic Annotation
more info
  
part_of protein-DNA complex IMP
Inferred from Mutant Phenotype
more info
 PubMed 
part_of protein-DNA complex IPI
Inferred from Physical Interaction
more info
 PubMed 
Preferred Names
transcriptional regulator PtxS
NP_250949.1
  • Product name confidence: class 1 (Function experimentally demonstrated in P. aeruginosa)

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_002516.2 Reference assembly

    Range
    2487856..2488878
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_250949.1 transcriptional regulator PtxS [Pseudomonas aeruginosa PAO1]

    See identical proteins and their annotated locations for NP_250949.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A3M5ET15
    Conserved Domains (2) summary
    smart00354
    Location:12 → 82
    HTH_LACI; helix_turn _helix lactose operon repressor
    cd06283
    Location:72 → 333
    PBP1_RegR_EndR_KdgR-like; ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials