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GGACT gamma-glutamylamine cyclotransferase [ Homo sapiens (human) ]

Gene ID: 87769, updated on 12-Oct-2019

Summary

Official Symbol
GGACTprovided by HGNC
Official Full Name
gamma-glutamylamine cyclotransferaseprovided by HGNC
Primary source
HGNC:HGNC:25100
See related
Ensembl:ENSG00000134864 MIM:613378
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
A2LD1
Summary
The protein encoded by this gene aids in the proteolytic degradation of crosslinked fibrin by breaking down isodipeptide L-gamma-glutamyl-L-epsilon-lysine, a byproduct of fibrin degradation. The reaction catalyzed by the encoded gamma-glutamylaminecyclotransferase produces 5-oxo-L-proline and a free alkylamine. Two transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Aug 2010]
Expression
Biased expression in kidney (RPKM 12.0), fat (RPKM 1.8) and 13 other tissues See more
Orthologs

Genomic context

See GGACT in Genome Data Viewer
Location:
13q32.3
Exon count:
5
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 13 NC_000013.11 (100530164..100588792, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (101182418..101241046, complement)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene propionyl-CoA carboxylase subunit alpha Neighboring gene uncharacterized LOC107984574 Neighboring gene PCCA antisense RNA 1 Neighboring gene ribosomal protein L7 like 1 pseudogene 6 Neighboring gene ribosomal protein S26 pseudogene 47 Neighboring gene cytochrome c oxidase subunit 5B pseudogene 6 Neighboring gene transmembrane O-mannosyltransferase targeting cadherins 4 Neighboring gene NALCN antisense RNA 1 Neighboring gene ADP ribosylation factor 4 pseudogene 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
gamma-glutamylaminecyclotransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cellular modified amino acid catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular exosome HDA PubMed 

General protein information

Preferred Names
gamma-glutamylaminecyclotransferase
Names
AIG2-like domain 1
AIG2-like domain-containing protein 1
NP_001182016.1
NP_149101.1
XP_005254140.1
XP_011519431.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001195087.1NP_001182016.1  gamma-glutamylaminecyclotransferase

    See identical proteins and their annotated locations for NP_001182016.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants encode the same protein.
    Source sequence(s)
    AK095850, AL136526
    Consensus CDS
    CCDS45066.1
    UniProtKB/Swiss-Prot
    Q9BVM4
    Conserved Domains (1) summary
    pfam06094
    Location:4119
    GGACT; Gamma-glutamyl cyclotransferase, AIG2-like
  2. NM_033110.2NP_149101.1  gamma-glutamylaminecyclotransferase

    See identical proteins and their annotated locations for NP_149101.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants encode the same protein.
    Source sequence(s)
    AL136526, DA628207
    Consensus CDS
    CCDS45066.1
    UniProtKB/Swiss-Prot
    Q9BVM4
    Related
    ENSP00000410449.1, ENST00000455100.2
    Conserved Domains (1) summary
    pfam06094
    Location:4119
    GGACT; Gamma-glutamyl cyclotransferase, AIG2-like

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p13 Primary Assembly

    Range
    100530164..100588792 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011521129.3XP_011519431.1  gamma-glutamylaminecyclotransferase isoform X1

    See identical proteins and their annotated locations for XP_011519431.1

    UniProtKB/Swiss-Prot
    Q9BVM4
    Conserved Domains (1) summary
    pfam06094
    Location:4119
    GGACT; Gamma-glutamyl cyclotransferase, AIG2-like
  2. XM_005254083.2XP_005254140.1  gamma-glutamylaminecyclotransferase isoform X1

    See identical proteins and their annotated locations for XP_005254140.1

    UniProtKB/Swiss-Prot
    Q9BVM4
    Conserved Domains (1) summary
    pfam06094
    Location:4119
    GGACT; Gamma-glutamyl cyclotransferase, AIG2-like
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