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GGACT gamma-glutamylamine cyclotransferase [ Homo sapiens (human) ]

Gene ID: 87769, updated on 23-Nov-2023

Summary

Official Symbol
GGACTprovided by HGNC
Official Full Name
gamma-glutamylamine cyclotransferaseprovided by HGNC
Primary source
HGNC:HGNC:25100
See related
Ensembl:ENSG00000134864 MIM:613378; AllianceGenome:HGNC:25100
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
A2LD1
Summary
The protein encoded by this gene aids in the proteolytic degradation of crosslinked fibrin by breaking down isodipeptide L-gamma-glutamyl-L-epsilon-lysine, a byproduct of fibrin degradation. The reaction catalyzed by the encoded gamma-glutamylaminecyclotransferase produces 5-oxo-L-proline and a free alkylamine. Two transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Aug 2010]
Expression
Biased expression in kidney (RPKM 12.0), fat (RPKM 1.8) and 13 other tissues See more
Orthologs
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Genomic context

See GGACT in Genome Data Viewer
Location:
13q32.3
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (100530180..100588789, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (99745466..99804072, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (101182434..101241043, complement)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene propionyl-CoA carboxylase subunit alpha Neighboring gene uncharacterized LOC107984574 Neighboring gene H3K27ac hESC enhancer GRCh37_chr13:101144770-101145270 Neighboring gene H3K27ac hESC enhancer GRCh37_chr13:101145271-101145771 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:101154747-101155384 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:101161543-101162161 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:101162781-101163398 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr13:101162162-101162780 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:101169316-101170040 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:101171491-101172156 Neighboring gene PCCA antisense RNA 1 Neighboring gene RPL7L1 pseudogene 6 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:101177366-101177888 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:101182623-101183592 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7960 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:101196750-101197473 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:101198945-101199623 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:101197474-101198196 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:101199624-101200301 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5477 Neighboring gene ribosomal protein S26 pseudogene 47 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:101279471-101279992 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:101311281-101311784 Neighboring gene H3K27ac hESC enhancer GRCh37_chr13:101325425-101326314 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5478 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5479 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5480 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7961 Neighboring gene cytochrome c oxidase subunit 5B pseudogene 6 Neighboring gene transmembrane O-mannosyltransferase targeting cadherins 4 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:101350546-101351126 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr13:101390455-101391100 Neighboring gene NALCN antisense RNA 1 Neighboring gene ADP ribosylation factor 4 pseudogene 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General protein information

Preferred Names
gamma-glutamylaminecyclotransferase
Names
AIG2-like domain 1
AIG2-like domain-containing protein 1
NP_001182016.1
NP_149101.1
XP_011519431.1
XP_047286664.1
XP_054231054.1
XP_054231055.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001195087.2NP_001182016.1  gamma-glutamylaminecyclotransferase

    See identical proteins and their annotated locations for NP_001182016.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants encode the same protein.
    Source sequence(s)
    AK095850, AL136526
    Consensus CDS
    CCDS45066.1
    UniProtKB/Swiss-Prot
    B3KTN1, Q9BT41, Q9BVM4
    Related
    ENSP00000508020.1, ENST00000683975.1
    Conserved Domains (1) summary
    pfam06094
    Location:4138
    GGACT; Gamma-glutamyl cyclotransferase, AIG2-like
  2. NM_033110.3NP_149101.1  gamma-glutamylaminecyclotransferase

    See identical proteins and their annotated locations for NP_149101.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants encode the same protein.
    Source sequence(s)
    AL136526, DA628207
    Consensus CDS
    CCDS45066.1
    UniProtKB/Swiss-Prot
    B3KTN1, Q9BT41, Q9BVM4
    Related
    ENSP00000410449.1, ENST00000455100.2
    Conserved Domains (1) summary
    pfam06094
    Location:4138
    GGACT; Gamma-glutamyl cyclotransferase, AIG2-like

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

    Range
    100530180..100588789 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047430708.1XP_047286664.1  gamma-glutamylaminecyclotransferase isoform X1

    UniProtKB/Swiss-Prot
    B3KTN1, Q9BT41, Q9BVM4
  2. XM_011521129.4XP_011519431.1  gamma-glutamylaminecyclotransferase isoform X1

    See identical proteins and their annotated locations for XP_011519431.1

    UniProtKB/Swiss-Prot
    B3KTN1, Q9BT41, Q9BVM4
    Conserved Domains (1) summary
    pfam06094
    Location:4138
    GGACT; Gamma-glutamyl cyclotransferase, AIG2-like

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060937.1 Alternate T2T-CHM13v2.0

    Range
    99745466..99804072 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054375080.1XP_054231055.1  gamma-glutamylaminecyclotransferase isoform X1

    UniProtKB/Swiss-Prot
    B3KTN1, Q9BT41, Q9BVM4
  2. XM_054375079.1XP_054231054.1  gamma-glutamylaminecyclotransferase isoform X1

    UniProtKB/Swiss-Prot
    B3KTN1, Q9BT41, Q9BVM4