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lspA lipoprotein signal peptidase [ Pseudomonas aeruginosa PAO1 ]

Gene ID: 877620, updated on 4-Feb-2026
Gene symbol
lspA
Gene description
lipoprotein signal peptidase
Locus tag
PA4559
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Pseudomonas aeruginosa PAO1 (strain: PAO1)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas
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Try the new Transcripts and proteins table
Sequence:
NC_002516.2 (5106449..5106958, complement)

NC_002516.2Genomic Context describing neighboring genes Neighboring gene type 4 fimbrial biogenesis protein PilY2 Neighboring gene type 4 fimbrial biogenesis protein PilE Neighboring gene 4-hydroxy-3-methylbut-2-enyl diphosphate reductase Neighboring gene FkbP-type peptidyl-prolyl cis-trans isomerase Neighboring gene isoleucine--tRNA ligase Neighboring gene bifunctional riboflavin kinase/FMN adenylyltransferase Neighboring gene hypothetical protein

Genomic Sequence:
NC_002516.2

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. The lspA gene, encoding the type II signal peptidase of Rickettsia typhi: transcriptional and functional analysis. Rahman MS, et al. J Bacteriol, 2007 Jan. PMID 17098907, Free PMC Article
  2. Structural basis of lipoprotein signal peptidase II action and inhibition by the antibiotic globomycin. Vogeley L, et al. Science, 2016 Feb 19. PMID 26912896
  3. Pseudomonas Genome Database: facilitating user-friendly, comprehensive comparisons of microbial genomes. Winsor GL, et al. Nucleic Acids Res, 2009 Jan. PMID 18978025, Free PMC Article
  4. Defining the Pseudomonas aeruginosa SOS response and its role in the global response to the antibiotic ciprofloxacin. Cirz RT, et al. J Bacteriol, 2006 Oct. PMID 17015649, Free PMC Article
  5. Cystic fibrosis sputum supports growth and cues key aspects of Pseudomonas aeruginosa physiology. Palmer KL, et al. J Bacteriol, 2005 Aug. PMID 16030221, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. this study reports the crystal structure of LspA from Pseudomonas aeruginosa complexed with the antimicrobial globomycin at 2.8 angstrom resolution.
    Title: Structural basis of lipoprotein signal peptidase II action and inhibition by the antibiotic globomycin.
Submit: New GeneRIF Correction

Homology

Gene Ontology Provided by PseudoCAP

Function Evidence Code Pubs
enables aspartic-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables aspartic-type endopeptidase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein maturation ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Preferred Names
lipoprotein signal peptidase
NP_253249.1
  • Product name confidence: class 2 (High similarity to functionally studied protein)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_002516.2 Reference assembly

    Range
    5106449..5106958 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_253249.1 lipoprotein signal peptidase [Pseudomonas aeruginosa PAO1]

    See identical proteins and their annotated locations for NP_253249.1

    Status: PROVISIONAL

    Conserved Domains (1) summary
    PRK00376
    Location:6 → 163
    lspA; lipoprotein signal peptidase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9HVM5.1

Gene LinkOut

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Molecular Biology Databases
Research Materials