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NAPG NSF attachment protein gamma [ Homo sapiens (human) ]

Gene ID: 8774, updated on 9-Feb-2020

Summary

Official Symbol
NAPGprovided by HGNC
Official Full Name
NSF attachment protein gammaprovided by HGNC
Primary source
HGNC:HGNC:7642
See related
Ensembl:ENSG00000134265 MIM:603216
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GAMMASNAP
Summary
This gene encodes soluble NSF attachment protein gamma. The soluble NSF attachment proteins (SNAPs) enable N-ethyl-maleimide-sensitive fusion protein (NSF) to bind to target membranes. NSF and SNAPs appear to be general components of the intracellular membrane fusion apparatus, and their action at specific sites of fusion must be controlled by SNAP receptors particular to the membranes being fused. The product of this gene mediates platelet exocytosis and controls the membrane fusion events of this process.[provided by RefSeq, Dec 2008]
Expression
Ubiquitous expression in brain (RPKM 18.0), thyroid (RPKM 9.1) and 25 other tissues See more
Orthologs

Genomic context

See NAPG in Genome Data Viewer
Location:
18p11.22
Exon count:
15
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 18 NC_000018.10 (10526027..10552769)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (10525873..10552766)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371988 Neighboring gene long intergenic non-protein coding RNA 1254 Neighboring gene APC down-regulated 1 Neighboring gene uncharacterized LOC105371990 Neighboring gene long intergenic non-protein coding RNA 1887 Neighboring gene coiled-coil domain containing 58 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
The 18p11.22 locus is associated with never smoker non-small cell lung cancer susceptibility in Korean populations.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
soluble NSF attachment protein activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
syntaxin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
intra-Golgi vesicle-mediated transport TAS
Traceable Author Statement
more info
PubMed 
intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
membrane fusion TAS
Traceable Author Statement
more info
PubMed 
protein stabilization NAS
Non-traceable Author Statement
more info
PubMed 
protein-containing complex assembly NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
SNARE complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular exosome HDA PubMed 
lysosomal membrane HDA PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
synapse IEA
Inferred from Electronic Annotation
more info
 
vacuolar membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
gamma-soluble NSF attachment protein
Names
N-ethylmaleimide-sensitive factor attachment protein, gamma
SNAP-gamma
soluble NSF attachment protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003826.3NP_003817.1  gamma-soluble NSF attachment protein

    See identical proteins and their annotated locations for NP_003817.1

    Status: REVIEWED

    Source sequence(s)
    AK023725, AK126942, AK314495, BC001889, CA312045, CK005676, DA296597
    Consensus CDS
    CCDS45827.1
    UniProtKB/Swiss-Prot
    Q99747
    UniProtKB/TrEMBL
    Q6FHY4
    Related
    ENSP00000324628.6, ENST00000322897.11
    Conserved Domains (1) summary
    cd15832
    Location:8278
    SNAP; Soluble N-ethylmaleimide-sensitive factor (NSF) Attachment Protein family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p13 Primary Assembly

    Range
    10526027..10552769
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011525754.2XP_011524056.1  gamma-soluble NSF attachment protein isoform X1

    Conserved Domains (1) summary
    cd15832
    Location:71338
    SNAP; Soluble N-ethylmaleimide-sensitive factor (NSF) Attachment Protein family
  2. XM_011525756.2XP_011524058.1  gamma-soluble NSF attachment protein isoform X2

    See identical proteins and their annotated locations for XP_011524058.1

    UniProtKB/Swiss-Prot
    Q99747
    Conserved Domains (2) summary
    cd15832
    Location:2964
    SNAP; TPR repeat [structural motif]
    cl24038
    Location:1196
    SNAP; Soluble N-ethylmaleimide-sensitive factor (NSF) Attachment Protein family
  3. XM_017026063.2XP_016881552.1  gamma-soluble NSF attachment protein isoform X3

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