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RIPK2 receptor interacting serine/threonine kinase 2 [ Homo sapiens (human) ]

Gene ID: 8767, updated on 21-Jan-2020

Summary

Official Symbol
RIPK2provided by HGNC
Official Full Name
receptor interacting serine/threonine kinase 2provided by HGNC
Primary source
HGNC:HGNC:10020
See related
Ensembl:ENSG00000104312 MIM:603455
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CCK; RICK; RIP2; CARD3; GIG30; CARDIAK
Summary
This gene encodes a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases. The encoded protein contains a C-terminal caspase activation and recruitment domain (CARD), and is a component of signaling complexes in both the innate and adaptive immune pathways. It is a potent activator of NF-kappaB and inducer of apoptosis in response to various stimuli. [provided by RefSeq, Jul 2008]
Expression
Broad expression in bone marrow (RPKM 26.8), gall bladder (RPKM 8.2) and 24 other tissues See more
Orthologs

Genomic context

See RIPK2 in Genome Data Viewer
Location:
8q21.3
Exon count:
12
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (89757816..89791064)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (90769335..90803292)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC112268015 Neighboring gene uncharacterized LOC101929709 Neighboring gene cytochrome c oxidase subunit 6B1 pseudogene 6 Neighboring gene RNA, U6 small nuclear 925, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Common genetic variation and performance on standardized cognitive tests.
NHGRI GWA Catalog
Discovery of six new susceptibility loci and analysis of pleiotropic effects in leprosy.
NHGRI GWA Catalog
Genomewide association study of leprosy.
NHGRI GWA Catalog
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
retropepsin gag-pol HIV-1 PR (WT, not D25N) cleaves over-expressed RIPK2 with high specificity and this cleavage is prevent by addition of Saquinavir (protease inhibitor) PubMed
gag-pol HIV-1 PR (D25N) binds RIPK2 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
CARD domain binding IDA
Inferred from Direct Assay
more info
PubMed 
CARD domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
LIM domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
caspase binding IPI
Inferred from Physical Interaction
more info
PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
non-membrane spanning protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
 
signaling receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
I-kappaB kinase/NF-kappaB signaling ISS
Inferred from Sequence or Structural Similarity
more info
 
JNK cascade TAS
Traceable Author Statement
more info
 
T cell proliferation IEA
Inferred from Electronic Annotation
more info
 
T cell receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
T cell receptor signaling pathway TAS
Traceable Author Statement
more info
 
activation of MAPK activity TAS
Traceable Author Statement
more info
 
activation of cysteine-type endopeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
adaptive immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
adaptive immune response ISS
Inferred from Sequence or Structural Similarity
more info
 
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
cellular response to lipoteichoic acid IEA
Inferred from Electronic Annotation
more info
 
cellular response to muramyl dipeptide IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to peptidoglycan IEA
Inferred from Electronic Annotation
more info
 
defense response to Gram-positive bacterium IEA
Inferred from Electronic Annotation
more info
 
inflammatory response TAS
Traceable Author Statement
more info
PubMed 
innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
innate immune response IDA
Inferred from Direct Assay
more info
PubMed 
innate immune response ISS
Inferred from Sequence or Structural Similarity
more info
 
interleukin-1-mediated signaling pathway TAS
Traceable Author Statement
more info
 
lipopolysaccharide-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
negative regulation of apoptotic process TAS
Traceable Author Statement
more info
 
nucleotide-binding oligomerization domain containing 1 signaling pathway IEA
Inferred from Electronic Annotation
more info
 
nucleotide-binding oligomerization domain containing 2 signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
nucleotide-binding oligomerization domain containing signaling pathway TAS
Traceable Author Statement
more info
 
peptidyl-tyrosine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of ERK1 and ERK2 cascade IEA
Inferred from Electronic Annotation
more info
 
positive regulation of I-kappaB kinase/NF-kappaB signaling IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of JNK cascade IEA
Inferred from Electronic Annotation
more info
 
positive regulation of NF-kappaB transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of NF-kappaB transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of NF-kappaB transcription factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of NF-kappaB transcription factor activity TAS
Traceable Author Statement
more info
 
positive regulation of T-helper 1 cell differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of alpha-beta T cell proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell death IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of chemokine production IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cytokine-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
positive regulation of immature T cell proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of interferon-alpha production NAS
Non-traceable Author Statement
more info
PubMed 
positive regulation of interferon-beta production NAS
Non-traceable Author Statement
more info
PubMed 
positive regulation of interferon-gamma production IEA
Inferred from Electronic Annotation
more info
 
positive regulation of interleukin-1 beta secretion IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of interleukin-12 production NAS
Non-traceable Author Statement
more info
PubMed 
positive regulation of interleukin-2 production IEA
Inferred from Electronic Annotation
more info
 
positive regulation of interleukin-6 production IEA
Inferred from Electronic Annotation
more info
 
positive regulation of peptidyl-serine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of peptidyl-threonine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein ubiquitination IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein ubiquitination NAS
Non-traceable Author Statement
more info
PubMed 
positive regulation of transcription by RNA polymerase II NAS
Non-traceable Author Statement
more info
PubMed 
positive regulation of tumor necrosis factor production IEA
Inferred from Electronic Annotation
more info
 
positive regulation of xenophagy IEA
Inferred from Electronic Annotation
more info
 
response to exogenous dsRNA IEA
Inferred from Electronic Annotation
more info
 
response to interleukin-12 IEA
Inferred from Electronic Annotation
more info
 
response to interleukin-18 IEA
Inferred from Electronic Annotation
more info
 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
toll-like receptor 2 signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
toll-like receptor 4 signaling pathway IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 
protein-containing complex IMP
Inferred from Mutant Phenotype
more info
PubMed 
vesicle IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
receptor-interacting serine/threonine-protein kinase 2
Names
CARD-carrying kinase
CARD-containing IL-1 beta ICE-kinase
CARD-containing interleukin-1 beta-converting enzyme (ICE)-associated kinase
RIP-2
growth-inhibiting gene 30
receptor-interacting protein (RIP)-like interacting caspase-like apoptosis regulatory protein (CLARP) kinase
receptor-interacting protein 2
tyrosine-protein kinase RIPK2
NP_001362289.1
NP_003812.1
XP_011515659.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033016.2 RefSeqGene

    Range
    5070..38318
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001375360.1NP_001362289.1  receptor-interacting serine/threonine-protein kinase 2 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AF117829
  2. NM_003821.6NP_003812.1  receptor-interacting serine/threonine-protein kinase 2 isoform 1

    See identical proteins and their annotated locations for NP_003812.1

    Status: REVIEWED

    Source sequence(s)
    AI824070, AY358814
    Consensus CDS
    CCDS6247.1
    UniProtKB/Swiss-Prot
    O43353
    UniProtKB/TrEMBL
    A0A0S2Z4Z8
    Related
    ENSP00000220751.4, ENST00000220751.5
    Conserved Domains (2) summary
    cd08786
    Location:438524
    CARD_RIP2_CARD3; Caspase activation and recruitment domain of Receptor Interacting Protein 2
    cd14026
    Location:20303
    STKc_RIP2; Catalytic domain of the Serine/Threonine kinase, Receptor Interacting Protein 2

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    89757816..89791064
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011517357.2XP_011515659.1  receptor-interacting serine/threonine-protein kinase 2 isoform X2

    Conserved Domains (2) summary
    cd08786
    Location:267353
    CARD_RIP2_CARD3; Caspase activation and recruitment domain of Receptor Interacting Protein 2
    cl21453
    Location:1132
    PKc_like; Protein Kinases, catalytic domain
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