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PABPC4 poly(A) binding protein cytoplasmic 4 [ Homo sapiens (human) ]

Gene ID: 8761, updated on 23-Nov-2021

Summary

Official Symbol
PABPC4provided by HGNC
Official Full Name
poly(A) binding protein cytoplasmic 4provided by HGNC
Primary source
HGNC:HGNC:8557
See related
Ensembl:ENSG00000090621 MIM:603407
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
APP1; APP-1; PABP4; iPABP
Summary
Poly(A)-binding proteins (PABPs) bind to the poly(A) tail present at the 3-prime ends of most eukaryotic mRNAs. PABPC4 or IPABP (inducible PABP) was isolated as an activation-induced T-cell mRNA encoding a protein. Activation of T cells increased PABPC4 mRNA levels in T cells approximately 5-fold. PABPC4 contains 4 RNA-binding domains and proline-rich C terminus. PABPC4 is localized primarily to the cytoplasm. It is suggested that PABPC4 might be necessary for regulation of stability of labile mRNA species in activated T cells. PABPC4 was also identified as an antigen, APP1 (activated-platelet protein-1), expressed on thrombin-activated rabbit platelets. PABPC4 may also be involved in the regulation of protein translation in platelets and megakaryocytes or may participate in the binding or stabilization of polyadenylates in platelet dense granules. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. This protein has also been found to interact with coronavirus nucleocapsid proteins and is thought to inhibit coronavirus replication. [provided by RefSeq, Nov 2021]
Annotation information
Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in immune response or antiviral activity.
Expression
Ubiquitous expression in testis (RPKM 55.5), ovary (RPKM 46.1) and 25 other tissues See more
Orthologs
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Genomic context

See PABPC4 in Genome Data Viewer
Location:
1p34.3
Exon count:
16
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (39560816..39576790, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (40026488..40042462, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene bone morphogenetic protein 8a Neighboring gene 3-oxoacid CoA-transferase 2 pseudogene 1 Neighboring gene peptidylprolyl isomerase E like pseudogene Neighboring gene PABPC4 antisense RNA 1 Neighboring gene small nucleolar RNA, H/ACA box 55 Neighboring gene hes related family bHLH transcription factor with YRPW motif like Neighboring gene Sharpr-MPRA regulatory region 4263 Neighboring gene 5'-nucleotidase, cytosolic IA

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Biological, clinical and population relevance of 95 loci for blood lipids.
GeneReviews: Not available
Discovery and refinement of loci associated with lipid levels.
GeneReviews: Not available
Meta-analysis of genome-wide association studies in >80 000 subjects identifies multiple loci for C-reactive protein levels.
GeneReviews: Not available

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify cytoplasmic poly(A) binding protein 4 (PABPC4), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify cytoplasmic poly(A) binding protein 4 (PABPC4), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Nef nef Tandem affinity purification and mass spectrometry analysis identify cytoplasmic poly(A) binding protein 4 (PABPC4), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify cytoplasmic poly(A) binding protein 4 (PABPC4), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
retropepsin gag-pol HIV-1 PR-induced PABP cleavage is involved in the inhibition of poly(A)-dependent translation. However, PABP cleavage has little impact on the translation of polyadenylated encephalomyocarditis virus internal ribosome entry site-containing mRNAs PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ43938

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables mRNA 3'-UTR binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables poly(A) binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables poly(A) binding IDA
Inferred from Direct Assay
more info
PubMed 
NOT enables poly(C) RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables poly(U) RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables poly(U) RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in RNA catabolic process TAS
Traceable Author Statement
more info
PubMed 
involved_in RNA processing TAS
Traceable Author Statement
more info
PubMed 
involved_in blood coagulation TAS
Traceable Author Statement
more info
PubMed 
involved_in myeloid cell development IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of mRNA stability IEA
Inferred from Electronic Annotation
more info
 
involved_in translation TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasmic stress granule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasmic stress granule IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
part_of ribonucleoprotein complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of ribonucleoprotein complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
polyadenylate-binding protein 4
Names
PABP-4
activated-platelet protein 1
inducible poly(A)-binding protein
poly(A) binding protein, cytoplasmic 4 (inducible form)
poly(A)-binding protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001135653.2NP_001129125.1  polyadenylate-binding protein 4 isoform 1

    See identical proteins and their annotated locations for NP_001129125.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    BC029969, BC094755
    Consensus CDS
    CCDS44115.1
    UniProtKB/Swiss-Prot
    Q13310
    Related
    ENSP00000361949.3, ENST00000372858.8
    Conserved Domains (1) summary
    TIGR01628
    Location:11640
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
  2. NM_001135654.2NP_001129126.1  polyadenylate-binding protein 4 isoform 3

    See identical proteins and their annotated locations for NP_001129126.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an in-frame coding exon, as compared to variant 1. The resulting isoform (3) lacks an internal segment, as compared to isoform 1.
    Source sequence(s)
    BC029969, BC065540, DB455681
    Consensus CDS
    CCDS44114.1
    UniProtKB/Swiss-Prot
    Q13310
    Related
    ENSP00000361947.3, ENST00000372856.7
    Conserved Domains (1) summary
    TIGR01628
    Location:11611
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
  3. NM_003819.4NP_003810.1  polyadenylate-binding protein 4 isoform 2

    See identical proteins and their annotated locations for NP_003810.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame segment in the coding region, as compared to variant 1. The resulting isoform 2 lacks an internal segment, as compared to isoform 1.
    Source sequence(s)
    BC029969, BC094755, DB455681, U33818
    Consensus CDS
    CCDS438.1
    UniProtKB/Swiss-Prot
    Q13310
    Related
    ENSP00000361948.3, ENST00000372857.7
    Conserved Domains (1) summary
    TIGR01628
    Location:11624
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    39560816..39576790 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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