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TNFSF10 TNF superfamily member 10 [ Homo sapiens (human) ]

Gene ID: 8743, updated on 1-Aug-2020

Summary

Official Symbol
TNFSF10provided by HGNC
Official Full Name
TNF superfamily member 10provided by HGNC
Primary source
HGNC:HGNC:11925
See related
Ensembl:ENSG00000121858 MIM:603598
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TL2; APO2L; CD253; TRAIL; Apo-2L; TNLG6A
Summary
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
Expression
Ubiquitous expression in lung (RPKM 64.9), placenta (RPKM 44.9) and 21 other tissues See more
Orthologs

Genomic context

See TNFSF10 in Genome Data Viewer
Location:
3q26.31
Exon count:
6
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (172505508..172523430, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (172223298..172241297, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene basic leucine zipper and W2 domains 1 pseudogene 1 Neighboring gene growth hormone secretagogue receptor Neighboring gene TBP-like 1 pseudogene Neighboring gene long intergenic non-protein coding RNA 2068 Neighboring gene solute carrier family 31 member 1 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Treatment of HIV-1 Env-pseudotyped virus-infected MDM cells with both soluble TRAIL and an agonistic anti-DR5 antibody AD5-10 induces activation of caspase-3, -8, and -9 PubMed
env Treatment of CD4+ T cells with HIV-1 gp120 results in the upregulation of TRAIL death receptor expression and acquired sensitivity to TRAIL mediated cell death; this effect of gp120 requires the chemokine coreceptor CXCR4, but not CCR5 or the CD4 receptor PubMed
env Treatment of human monocytes and primary neutrophils with N36 peptide from HIV-1 gp41 and F peptide from HIV-1 envelope protein gp120 increases endogenous tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) expression PubMed
Envelope transmembrane glycoprotein gp41 env Treatment of human monocytes and primary neutrophils with N36 peptide from HIV-1 gp41 and F peptide from HIV-1 envelope protein gp120 increases endogenous tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) expression PubMed
Tat tat Microarray analysis indicates HIV-1 Tat-induced upregulation of tumor necrosis factor (ligand) superfamily, member 10 (TNFSF10; TRAIL) in primary human brain microvascular endothelial cells PubMed
tat HIV-1 and the viral protein Tat modulate the expression of tumor necrosis factor (ligand) superfamily, member 10 (TNFSF10; TRAIL) in immature dendritic cells and monocyte-derived macrophages PubMed
tat Microarray analysis indicates HIV-1 Tat upregulates the interferon-responsive gene expression of many proteins, including TRAIL, in immature dendritic cells, an effect that likely facilitates the expansion of HIV-1 infection PubMed
tat HIV-1 Tat inhibits apoptosis mediated by TRAIL in Jurkat T cells PubMed
tat Upregulation of TRAIL by HIV-1 Tat induces bystander-mediated apoptosis in T cells PubMed
Vif vif HIV-1 Vif downregulates the expression of tumor necrosis factor ligand superfamily, member 10 (TNFSF10) in Vif-expression T cells PubMed
Vpr vpr HIV-1 Vpr upregulates the expression of TRAIL in human monocyte-derived dendritic cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
TRAIL binding IEA
Inferred from Electronic Annotation
more info
 
cytokine activity IEA
Inferred from Electronic Annotation
more info
 
identical protein binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
signaling receptor binding TAS
Traceable Author Statement
more info
PubMed 
tumor necrosis factor receptor binding IEA
Inferred from Electronic Annotation
more info
 
zinc ion binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
activation of cysteine-type endopeptidase activity involved in apoptotic process TAS
Traceable Author Statement
more info
 
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
cell surface receptor signaling pathway TAS
Traceable Author Statement
more info
 
cell-cell signaling TAS
Traceable Author Statement
more info
PubMed 
immune response IEA
Inferred from Electronic Annotation
more info
 
male gonad development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors TAS
Traceable Author Statement
more info
 
positive regulation of I-kappaB kinase/NF-kappaB signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of I-kappaB kinase/NF-kappaB signaling IEP
Inferred from Expression Pattern
more info
PubMed 
positive regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of extrinsic apoptotic signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of extrinsic apoptotic signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of release of cytochrome c from mitochondria IDA
Inferred from Direct Assay
more info
PubMed 
regulation of extrinsic apoptotic signaling pathway via death domain receptors TAS
Traceable Author Statement
more info
 
response to insulin IEA
Inferred from Electronic Annotation
more info
 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
extracellular exosome HDA PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
tumor necrosis factor ligand superfamily member 10
Names
Apo-2 ligand
TNF-related apoptosis inducing ligand TRAIL
chemokine tumor necrosis factor ligand superfamily member 10
tumor necrosis factor (ligand) family, member 10
tumor necrosis factor (ligand) superfamily, member 10
tumor necrosis factor apoptosis-inducing ligand splice variant delta
tumor necrosis factor ligand 6A
tumor necrosis factor superfamily member 10

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001190942.2NP_001177871.1  tumor necrosis factor ligand superfamily member 10 isoform 2

    See identical proteins and their annotated locations for NP_001177871.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks two consecutive exons in the CDS, resulting in a frame-shift, as compared to variant 1. The resulting isoform (2) is shorter and has a different C-terminus, as compared to isoform 1.
    Source sequence(s)
    AC016938, AK296085
    Consensus CDS
    CCDS54680.1
    UniProtKB/Swiss-Prot
    P50591
    Related
    ENSP00000389931.2, ENST00000420541.6
  2. NM_001190943.2NP_001177872.1  tumor necrosis factor ligand superfamily member 10 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks multiple 3' exons, but has an alternate 3' exon, as compared to variant 1. The resulting isoform (3) is very short and has a different C-terminus, as compared to isoform 1.
    Source sequence(s)
    AC007919, AC016938
    Related
    ENST00000466777.1
  3. NM_003810.4NP_003801.1  tumor necrosis factor ligand superfamily member 10 isoform 1

    See identical proteins and their annotated locations for NP_003801.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC007919, AC016938
    Consensus CDS
    CCDS3219.1
    UniProtKB/Swiss-Prot
    P50591
    UniProtKB/TrEMBL
    Q6IBA9
    Related
    ENSP00000241261.2, ENST00000241261.7
    Conserved Domains (1) summary
    pfam00229
    Location:153280
    TNF; TNF(tumor Necrosis Factor) family

RNA

  1. NR_033994.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an internal exon in the CDS, resulting in frame-shift and a premature translation termination, as compared to variant 1. The transcript is a nonsense-mediated mRNA decay candidate.
    Source sequence(s)
    AC016938, DA041872

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    172505508..172523430 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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