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TNFSF12 TNF superfamily member 12 [ Homo sapiens (human) ]

Gene ID: 8742, updated on 11-Sep-2019

Summary

Official Symbol
TNFSF12provided by HGNC
Official Full Name
TNF superfamily member 12provided by HGNC
Primary source
HGNC:HGNC:11927
See related
Ensembl:ENSG00000239697 MIM:602695
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
APO3L; DR3LG; TWEAK; TNLG4A
Summary
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is a ligand for the FN14/TWEAKR receptor. This cytokine has overlapping signaling functions with TNF, but displays a much wider tissue distribution. This cytokine, which exists in both membrane-bound and secreted forms, can induce apoptosis via multiple pathways of cell death in a cell type-specific manner. This cytokine is also found to promote proliferation and migration of endothelial cells, and thus acts as a regulator of angiogenesis. Alternative splicing results in multiple transcript variants. Some transcripts skip the last exon of this gene and continue into the second exon of the neighboring TNFSF13 gene; such read-through transcripts are contained in GeneID 407977, TNFSF12-TNFSF13. [provided by RefSeq, Oct 2010]
Expression
Ubiquitous expression in fat (RPKM 27.5), lung (RPKM 20.2) and 25 other tissues See more
Orthologs

Genomic context

See TNFSF12 in Genome Data Viewer
Location:
17p13.1
Exon count:
8
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (7549058..7557881)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (7452375..7461207)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene zinc finger and BTB domain containing 4 Neighboring gene solute carrier family 35 member G6 Neighboring gene RNA polymerase II subunit A Neighboring gene TNFSF12-TNFSF13 readthrough Neighboring gene SENP3-EIF4A1 readthrough (NMD candidate) Neighboring gene TNF superfamily member 13 Neighboring gene SUMO specific peptidase 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from BioSystems

  • Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
    Cytokine Signaling in Immune system, organism-specific biosystemCytokines are small proteins that regulate and mediate immunity, inflammation, and hematopoiesis. They are secreted in response to immune stimuli, and usually act briefly, locally, at very low concen...
  • Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
    Cytokine-cytokine receptor interaction, organism-specific biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
  • Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
    Cytokine-cytokine receptor interaction, conserved biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway, organism-specific biosystem (from REACTOME)
    TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway, organism-specific biosystemActivation of NF-kB is fundamental to signal transduction by members of the TNFRSF. Expression of NF-kB target genes is essential for mounting innate immune responses to infectious microorganisms but...
  • TNF related weak inducer of apoptosis (TWEAK) Signaling Pathway, organism-specific biosystem (from WikiPathways)
    TNF related weak inducer of apoptosis (TWEAK) Signaling Pathway, organism-specific biosystemTNF related weak inducer of apoptosis (TWEAK) is a small pleiotropic cytokine of the TNF super family and its gene is located at chromosome 17p13.1. TWEAK has been reported to be expressed in tissues...
  • TNFR2 non-canonical NF-kB pathway, organism-specific biosystem (from REACTOME)
    TNFR2 non-canonical NF-kB pathway, organism-specific biosystemTumor necrosis factor-alpha (TNFA) exerts a wide range of biological effects through TNF receptor 1 (TNFR1) and TNF receptor 2 (TNFR2). Under normal physiological conditions TNFR2 exhibits more restr...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Readthrough TNFSF12-TNFSF13

Readthrough gene: TNFSF12-TNFSF13, Included gene: TNFSF13

Homology

Clone Names

  • MGC20669, MGC129581

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cytokine activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
signaling receptor binding TAS
Traceable Author Statement
more info
PubMed 
tumor necrosis factor receptor binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
angiogenesis IEA
Inferred from Electronic Annotation
more info
 
apoptotic process TAS
Traceable Author Statement
more info
PubMed 
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
endothelial cell migration TAS
Traceable Author Statement
more info
PubMed 
extrinsic apoptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
 
immune response IEA
Inferred from Electronic Annotation
more info
 
positive regulation of angiogenesis TAS
Traceable Author Statement
more info
PubMed 
positive regulation of endothelial cell proliferation TAS
Traceable Author Statement
more info
PubMed 
positive regulation of extrinsic apoptotic signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
tumor necrosis factor-mediated signaling pathway TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
tumor necrosis factor ligand superfamily member 12
Names
APO3 ligand
APO3/DR3 ligand
TNF-related WEAK inducer of apoptosis
tumor necrosis factor (ligand) superfamily, member 12
tumor necrosis factor ligand 4A
tumor necrosis factor superfamily member 12

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_052944.1 RefSeqGene

    Range
    5001..13824
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_1320

mRNA and Protein(s)

  1. NM_003809.3NP_003800.1  tumor necrosis factor ligand superfamily member 12 proprotein

    See identical proteins and their annotated locations for NP_003800.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript but encodes the functional protein.
    Source sequence(s)
    AF030099, AI091441, BC104420
    Consensus CDS
    CCDS11109.1
    UniProtKB/Swiss-Prot
    O43508
    UniProtKB/TrEMBL
    Q4ACW9
    Related
    ENSP00000293825.6, ENST00000293825.11
    Conserved Domains (1) summary
    smart00207
    Location:131248
    TNF; Tumour necrosis factor family

RNA

  1. NR_037146.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) includes an additional exon in the central region, compared to variant 1. This variant is represented as non-coding because the use of the supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    BC019047
    Related
    ENST00000322272.11

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    7549058..7557881
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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