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CTNNAL1 catenin alpha like 1 [ Homo sapiens (human) ]

Gene ID: 8727, updated on 4-Jul-2021

Summary

Official Symbol
CTNNAL1provided by HGNC
Official Full Name
catenin alpha like 1provided by HGNC
Primary source
HGNC:HGNC:2512
See related
Ensembl:ENSG00000119326 MIM:604785
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ACRP; CLLP; alpha-CATU
Expression
Broad expression in adrenal (RPKM 101.6), ovary (RPKM 57.7) and 22 other tissues See more
Orthologs
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Genomic context

See CTNNAL1 in Genome Data Viewer
Location:
9q31.3
Exon count:
20
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (108942569..109013535, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (111704857..111775779, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene actin like 7A Neighboring gene elongator acetyltransferase complex subunit 1 Neighboring gene actin binding transcription modulator Neighboring gene uncharacterized LOC105376216 Neighboring gene RNA, 5.8S ribosomal pseudogene 3 Neighboring gene transmembrane protein 245 Neighboring gene microRNA 32 Neighboring gene ferric chelate reductase 1 like

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ08121

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables actin filament binding IEA
Inferred from Electronic Annotation
more info
 
enables cadherin binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within Rho protein signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
alpha-catulin
Names
alpha-catenin-related protein
alpha2-catulin
catenin (cadherin-associated protein), alpha-like 1
catenin alpha-like protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001286974.2NP_001273903.1  alpha-catulin isoform b

    See identical proteins and their annotated locations for NP_001273903.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 3' terminal exon, which results in an alternate 3' coding region, compared to variant 1. The encoded isoform (b) has a distinct C-terminus and is shorter than isoform a.
    Source sequence(s)
    AF135021, AI148526, AK022926
    Consensus CDS
    CCDS69638.1
    UniProtKB/Swiss-Prot
    Q9UBT7
    UniProtKB/TrEMBL
    B3KMX6
    Related
    ENSP00000363723.4, ENST00000374595.8
    Conserved Domains (1) summary
    pfam01044
    Location:92675
    Vinculin; Vinculin family
  2. NM_003798.4NP_003789.1  alpha-catulin isoform a

    See identical proteins and their annotated locations for NP_003789.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript but encodes the longer isoform (a).
    Source sequence(s)
    AF030233, AK022926
    Consensus CDS
    CCDS6775.1
    UniProtKB/Swiss-Prot
    Q9UBT7
    UniProtKB/TrEMBL
    B3KMX6
    Related
    ENSP00000320434.4, ENST00000325551.9
    Conserved Domains (1) summary
    pfam01044
    Location:92675
    Vinculin; Vinculin family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    108942569..109013535 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017015250.2XP_016870739.1  alpha-catulin isoform X2

  2. XM_005252291.4XP_005252348.1  alpha-catulin isoform X1

    Conserved Domains (1) summary
    pfam01044
    Location:92675
    Vinculin; Vinculin family
  3. XM_017015251.1XP_016870740.1  alpha-catulin isoform X3

RNA

  1. XR_001746410.2 RNA Sequence

  2. XR_002956816.1 RNA Sequence

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