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NOL4 nucleolar protein 4 [ Homo sapiens (human) ]

Gene ID: 8715, updated on 27-Nov-2024

Summary

Official Symbol
NOL4provided by HGNC
Official Full Name
nucleolar protein 4provided by HGNC
Primary source
HGNC:HGNC:7870
See related
Ensembl:ENSG00000101746 MIM:603577; AllianceGenome:HGNC:7870
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NOLP; CT125; HRIHFB2255
Summary
Predicted to enable RNA binding activity. Predicted to be located in nucleolus. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in brain (RPKM 3.8), testis (RPKM 3.2) and 4 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See NOL4 in Genome Data Viewer
Location:
18q12.1
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 18 NC_000018.10 (33851100..34224913, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 18 NC_060942.1 (34042633..34416765, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (31431064..31804877, complement)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372059 Neighboring gene coiled-coil domain containing 178 Neighboring gene Sharpr-MPRA regulatory region 1696 Neighboring gene NANOG hESC enhancer GRCh37_chr18:30880684-30881216 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr18:31003580-31004779 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:31157523-31158511 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:31158512-31159499 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr18:31164967-31165678 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13213 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9391 Neighboring gene uncharacterized LOC124904347 Neighboring gene ASXL transcriptional regulator 3 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr18:31416777-31417720 Neighboring gene NANOG hESC enhancer GRCh37_chr18:31583567-31584247 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9392 Neighboring gene uncharacterized LOC124904279 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:31802111-31802612 Neighboring gene uncharacterized LOC124904280 Neighboring gene ReSE screen-validated silencer GRCh37_chr18:31864116-31864338 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13214 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13215 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9393 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr18:32128465-32129021 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr18:32129022-32129577 Neighboring gene NANOG hESC enhancer GRCh37_chr18:32142500-32143095 Neighboring gene ribosomal protein L10a pseudogene 13 Neighboring gene dystrobrevin alpha

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
A genomewide association study of citalopram response in major depressive disorder.
EBI GWAS Catalog
Genetic variants associated with breast size also influence breast cancer risk.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding TAS
Traceable Author Statement
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
nucleolar protein 4
Names
cancer/testis antigen 125
nucleolar localized protein

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001198546.1NP_001185475.1  nucleolar protein 4 isoform 2

    See identical proteins and their annotated locations for NP_001185475.1

    Status: VALIDATED

    Source sequence(s)
    AA430033, AB017800, AK297185, BC000313, BM973283, CA865522, CK822635
    UniProtKB/TrEMBL
    K7EQ17
    Related
    ENSP00000467629.1, ENST00000590712.5
  2. NM_001198547.2NP_001185476.1  nucleolar protein 4 isoform 3

    See identical proteins and their annotated locations for NP_001185476.1

    Status: VALIDATED

    Source sequence(s)
    AA430033, AK299850, BC000313, BM973283, CA865522, CK822635, DC375356
    Consensus CDS
    CCDS56059.1
    UniProtKB/TrEMBL
    B4DLW2
    Related
    ENSP00000443472.1, ENST00000538587.5
  3. NM_001198548.1NP_001185477.1  nucleolar protein 4 isoform 4

    See identical proteins and their annotated locations for NP_001185477.1

    Status: VALIDATED

    Source sequence(s)
    AA430033, AB017800, BC000313, BM973283, CA865522, CK822635
    Consensus CDS
    CCDS59308.1
    UniProtKB/TrEMBL
    K7EQ17
    Related
    ENSP00000465450.1, ENST00000589544.5
  4. NM_001198549.2NP_001185478.1  nucleolar protein 4 isoform 5

    See identical proteins and their annotated locations for NP_001185478.1

    Status: VALIDATED

    Source sequence(s)
    AA430033, AK296539, BC000313, BM973283, CA865522, CK822635, DC350556
    Consensus CDS
    CCDS56058.1
    UniProtKB/Swiss-Prot
    O94818
    Related
    ENSP00000445733.1, ENST00000535384.5
  5. NM_001282527.2NP_001269456.1  nucleolar protein 4 isoform 6

    See identical proteins and their annotated locations for NP_001269456.1

    Status: VALIDATED

    Source sequence(s)
    AA430033, AK091463, BC000313, BM973283, CA865522, CK822635, DC375356
    UniProtKB/TrEMBL
    B3KRF4, B4DLW2
  6. NM_001353232.1NP_001340161.1  nucleolar protein 4 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC010798, AC018972, AC087397, AC104985, BM973283
  7. NM_001353233.1NP_001340162.1  nucleolar protein 4 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC010798, AC018972, AC087397, AC104985, BM973283
  8. NM_001353234.2NP_001340163.1  nucleolar protein 4 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC010798, AC018972, AC087397, AC104985, BM973283
    UniProtKB/TrEMBL
    B4DLW2
  9. NM_001353235.2NP_001340164.1  nucleolar protein 4 isoform 10

    Status: VALIDATED

    Source sequence(s)
    AC010798, AC018972, AC087397, AC104985, BM973283
    UniProtKB/TrEMBL
    B4DLW2
  10. NM_001353236.2NP_001340165.1  nucleolar protein 4 isoform 11

    Status: VALIDATED

    Source sequence(s)
    AC010798, AC018972, AC087397, BM973283
  11. NM_001353237.1NP_001340166.1  nucleolar protein 4 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC010798, AC018972, AC087397, AC104985, BM973283
    UniProtKB/TrEMBL
    B3KRF4, B4DLW2
  12. NM_001384467.1NP_001371396.1  nucleolar protein 4 isoform 13

    Status: VALIDATED

    Source sequence(s)
    AC010798, AC018972, AC087397, AC104985
    UniProtKB/TrEMBL
    K7EQ17
    Conserved Domains (1) summary
    NF033845
    Location:231400
    MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB
  13. NM_001384468.1NP_001371397.1  nucleolar protein 4 isoform 14

    Status: VALIDATED

    Source sequence(s)
    AC010798, AC018972, AC087397, AC104985
    UniProtKB/TrEMBL
    K7EQ17
    Conserved Domains (1) summary
    NF033845
    Location:231400
    MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB
  14. NM_001384469.1NP_001371398.1  nucleolar protein 4 isoform 15

    Status: VALIDATED

    Source sequence(s)
    AC010798, AC018972, AC087397, AC104985
    UniProtKB/TrEMBL
    K7EQ17
    Conserved Domains (1) summary
    NF033845
    Location:229398
    MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB
  15. NM_001384470.1NP_001371399.1  nucleolar protein 4 isoform 16

    Status: VALIDATED

    Source sequence(s)
    AC010798, AC018972, AC087397, AC104985
    UniProtKB/TrEMBL
    B4DLW2
    Conserved Domains (1) summary
    pfam17921
    Location:1550
    Integrase_H2C2; Integrase zinc binding domain
  16. NM_001384471.1NP_001371400.1  nucleolar protein 4 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC010798, AC018972, AC087397, AC104985
    UniProtKB/TrEMBL
    B3KRF4, B4DLW2
  17. NM_001384472.1NP_001371401.1  nucleolar protein 4 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC010798, AC018972, AC087397, AC104985
    Consensus CDS
    CCDS56058.1
  18. NM_001384473.1NP_001371402.1  nucleolar protein 4 isoform 17

    Status: VALIDATED

    Source sequence(s)
    AC010798, AC018972, AC087397, AC104985
  19. NM_003787.5NP_003778.2  nucleolar protein 4 isoform 1

    See identical proteins and their annotated locations for NP_003778.2

    Status: VALIDATED

    Source sequence(s)
    AC010798, AC018972, AC087397, AC104985
    Consensus CDS
    CCDS11907.2
    UniProtKB/Swiss-Prot
    B4DSQ0, B7Z3Z7, F5H1E3, O94818, Q6IBS2, Q9BWF1
    UniProtKB/TrEMBL
    K7EQ17
    Related
    ENSP00000261592.4, ENST00000261592.10

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p14 Primary Assembly

    Range
    33851100..34224913 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047437902.1XP_047293858.1  nucleolar protein 4 isoform X1

    UniProtKB/Swiss-Prot
    B4DSQ0, B7Z3Z7, F5H1E3, O94818, Q6IBS2, Q9BWF1
  2. XM_047437901.1XP_047293857.1  nucleolar protein 4 isoform X1

    UniProtKB/Swiss-Prot
    B4DSQ0, B7Z3Z7, F5H1E3, O94818, Q6IBS2, Q9BWF1
  3. XM_011526238.3XP_011524540.1  nucleolar protein 4 isoform X2

    See identical proteins and their annotated locations for XP_011524540.1

    UniProtKB/TrEMBL
    B4DLW2
  4. XM_011526237.3XP_011524539.1  nucleolar protein 4 isoform X1

    See identical proteins and their annotated locations for XP_011524539.1

    UniProtKB/Swiss-Prot
    B4DSQ0, B7Z3Z7, F5H1E3, O94818, Q6IBS2, Q9BWF1
    UniProtKB/TrEMBL
    K7EQ17
  5. XM_006722563.4XP_006722626.1  nucleolar protein 4 isoform X1

    See identical proteins and their annotated locations for XP_006722626.1

    UniProtKB/Swiss-Prot
    B4DSQ0, B7Z3Z7, F5H1E3, O94818, Q6IBS2, Q9BWF1
    UniProtKB/TrEMBL
    K7EQ17
  6. XM_024451279.2XP_024307047.1  nucleolar protein 4 isoform X2

    UniProtKB/TrEMBL
    B4DLW2
  7. XM_011526239.4XP_011524541.1  nucleolar protein 4 isoform X4

    See identical proteins and their annotated locations for XP_011524541.1

    UniProtKB/TrEMBL
    B4DLW2
  8. XM_017026058.3XP_016881547.1  nucleolar protein 4 isoform X4

    UniProtKB/TrEMBL
    B4DLW2
  9. XM_047437905.1XP_047293861.1  nucleolar protein 4 isoform X7

    UniProtKB/TrEMBL
    B3KRF4
  10. XM_017026053.2XP_016881542.1  nucleolar protein 4 isoform X4

    UniProtKB/TrEMBL
    B4DLW2
  11. XM_017026052.2XP_016881541.1  nucleolar protein 4 isoform X3

    UniProtKB/TrEMBL
    B4DLW2
  12. XM_047437904.1XP_047293860.1  nucleolar protein 4 isoform X6

  13. XM_047437903.1XP_047293859.1  nucleolar protein 4 isoform X5

RNA

  1. XR_935261.4 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060942.1 Alternate T2T-CHM13v2.0

    Range
    34042633..34416765 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054319293.1XP_054175268.1  nucleolar protein 4 isoform X2

  2. XM_054319292.1XP_054175267.1  nucleolar protein 4 isoform X1

    UniProtKB/Swiss-Prot
    B4DSQ0, B7Z3Z7, F5H1E3, O94818, Q6IBS2, Q9BWF1
  3. XM_054319291.1XP_054175266.1  nucleolar protein 4 isoform X1

    UniProtKB/Swiss-Prot
    B4DSQ0, B7Z3Z7, F5H1E3, O94818, Q6IBS2, Q9BWF1
  4. XM_054319294.1XP_054175269.1  nucleolar protein 4 isoform X2

  5. XM_054319297.1XP_054175272.1  nucleolar protein 4 isoform X4

  6. XM_054319296.1XP_054175271.1  nucleolar protein 4 isoform X4

  7. XM_054319295.1XP_054175270.1  nucleolar protein 4 isoform X3

  8. XM_054319299.1XP_054175274.1  nucleolar protein 4 isoform X6

  9. XM_054319298.1XP_054175273.1  nucleolar protein 4 isoform X5

RNA

  1. XR_008485030.1 RNA Sequence