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B3GALT2 beta-1,3-galactosyltransferase 2 [ Homo sapiens (human) ]

Gene ID: 8707, updated on 18-Aug-2020

Summary

Official Symbol
B3GALT2provided by HGNC
Official Full Name
beta-1,3-galactosyltransferase 2provided by HGNC
Primary source
HGNC:HGNC:917
See related
Ensembl:ENSG00000162630 MIM:603018
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GLCT2; BETA3GALT2; beta3Gal-T2
Summary
This gene is a member of the beta-1,3-galactosyltransferase (beta3GalT) gene family. This family encodes type II membrane-bound glycoproteins with diverse enzymatic functions using different donor substrates (UDP-galactose and UDP-N-acetylglucosamine) and different acceptor sugars (N-acetylglucosamine, galactose, N-acetylgalactosamine). The beta3GalT genes are distantly related to the Drosophila Brainiac gene and have the protein coding sequence contained in a single exon. The beta3GalT proteins also contain conserved sequences not found in the beta4GalT or alpha3GalT proteins. The carbohydrate chains synthesized by these enzymes are designated as type 1, whereas beta4GalT enzymes synthesize type 2 carbohydrate chains. The ratio of type 1:type 2 chains changes during embryogenesis. By sequence similarity, the beta3GalT genes fall into at least two groups: beta3GalT4 and 4 other beta3GalT genes (beta3GalT1-3, beta3GalT5). This gene encodes a protein that functions in N-linked glycoprotein glycosylation and shows strict donor substrate specificity for UDP-galactose. [provided by RefSeq, Jul 2008]
Expression
Biased expression in gall bladder (RPKM 11.6), brain (RPKM 11.4) and 11 other tissues See more
Orthologs

Genomic context

See B3GALT2 in Genome Data Viewer
Location:
1q31.2
Exon count:
2
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (193178730..193186613, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (193147860..193155743, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101929160 Neighboring gene microRNA 1278 Neighboring gene cell division cycle 73 Neighboring gene long intergenic non-protein coding RNA 1031 Neighboring gene ribosomal protein L23a pseudogene 22

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp160, precursor env Oligosaccharide side-chains of HIV-1 gp160 are processed by glycosidase I and II, mannosidase I and II, acetylglucosaminyl transferase I and II, and fucosyl, galactosyl and sialyl transferases in both the endoplasmic reticulum and golgi apparatus PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
galactosylceramide biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
oligosaccharide biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
poly-N-acetyllactosamine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein glycosylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Golgi membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
beta-1,3-galactosyltransferase 2
Names
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2
UDP-galactose:2-acetamido-2-deoxy-D-glucose 3beta-galactosyltransferase 2
beta-1,3-GalTase 2
beta-3-galt2
NP_003774.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_052990.1 RefSeqGene

    Range
    5001..12884
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_003783.3NP_003774.1  beta-1,3-galactosyltransferase 2

    See identical proteins and their annotated locations for NP_003774.1

    Status: REVIEWED

    Source sequence(s)
    AK314116, AL390863, DA116294
    Consensus CDS
    CCDS1383.1
    UniProtKB/Swiss-Prot
    O43825
    Related
    ENSP00000356404.4, ENST00000367434.5
    Conserved Domains (1) summary
    pfam01762
    Location:165359
    Galactosyl_T; Galactosyltransferase

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    193178730..193186613 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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