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B3GALT2 beta-1,3-galactosyltransferase 2 [ Homo sapiens (human) ]

Gene ID: 8707, updated on 7-Sep-2023


Official Symbol
B3GALT2provided by HGNC
Official Full Name
beta-1,3-galactosyltransferase 2provided by HGNC
Primary source
See related
Ensembl:ENSG00000162630 MIM:603018; AllianceGenome:HGNC:917
Gene type
protein coding
RefSeq status
Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GLCT2; BETA3GALT2; beta3Gal-T2
This gene is a member of the beta-1,3-galactosyltransferase (beta3GalT) gene family. This family encodes type II membrane-bound glycoproteins with diverse enzymatic functions using different donor substrates (UDP-galactose and UDP-N-acetylglucosamine) and different acceptor sugars (N-acetylglucosamine, galactose, N-acetylgalactosamine). The beta3GalT genes are distantly related to the Drosophila Brainiac gene and have the protein coding sequence contained in a single exon. The beta3GalT proteins also contain conserved sequences not found in the beta4GalT or alpha3GalT proteins. The carbohydrate chains synthesized by these enzymes are designated as type 1, whereas beta4GalT enzymes synthesize type 2 carbohydrate chains. The ratio of type 1:type 2 chains changes during embryogenesis. By sequence similarity, the beta3GalT genes fall into at least two groups: beta3GalT4 and 4 other beta3GalT genes (beta3GalT1-3, beta3GalT5). This gene encodes a protein that functions in N-linked glycoprotein glycosylation and shows strict donor substrate specificity for UDP-galactose. [provided by RefSeq, Jul 2008]
Biased expression in gall bladder (RPKM 11.6), brain (RPKM 11.4) and 11 other tissues See more
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Genomic context

See B3GALT2 in Genome Data Viewer
Exon count:
Annotation release Status Assembly Chr Location
RS_2023_03 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (193178730..193186613, complement)
RS_2023_03 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (192525974..192533857, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (193147860..193155743, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124904474 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:193082253-193083159 Neighboring gene Sharpr-MPRA regulatory region 4625 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:193090658-193091304 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:193091305-193091949 Neighboring gene microRNA 1278 Neighboring gene cell division cycle 73 Neighboring gene long intergenic non-protein coding RNA 1031 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr1:193324401-193325600 Neighboring gene uncharacterized LOC124904475 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr1:193583455-193584654 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:193692068-193692676 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:193692677-193693283 Neighboring gene uncharacterized LOC124904676

Genomic regions, transcripts, and products


  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp160, precursor env Oligosaccharide side-chains of HIV-1 gp160 are processed by glycosidase I and II, mannosidase I and II, acetylglucosaminyl transferase I and II, and fucosyl, galactosyl and sialyl transferases in both the endoplasmic reticulum and golgi apparatus PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem


Products Interactant Other Gene Complex Source Pubs Description

General protein information

Preferred Names
beta-1,3-galactosyltransferase 2
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2
UDP-galactose:2-acetamido-2-deoxy-D-glucose 3beta-galactosyltransferase 2
beta-1,3-GalTase 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.


  1. NG_052990.1 RefSeqGene

    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_003783.3NP_003774.1  beta-1,3-galactosyltransferase 2

    See identical proteins and their annotated locations for NP_003774.1

    Status: REVIEWED

    Source sequence(s)
    AK314116, AL390863, DA116294
    Consensus CDS
    B2RAB1, O43825, Q9BZQ9
    ENSP00000356404.4, ENST00000367434.5
    Conserved Domains (1) summary
    Galactosyl_T; Galactosyltransferase

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_03

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly


  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    193178730..193186613 complement
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0


  1. NC_060925.1 Alternate T2T-CHM13v2.0

    192525974..192533857 complement
    GenBank, FASTA, Sequence Viewer (Graphics)